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PubMed | Pancreatic Cancer Research Group and University of Newcastle
Type: | Journal: Chemistry & biodiversity | Year: 2016

While the pharmacological and toxicological properties of eucalypts are well known in indigenous Australian medicinal practice, investigations of the bioactivity of eucalypt extracts against high mortality diseases such as pancreatic cancer in Western medicine have to date been limited, particularly amongst the genera Corymbia and Angophora. Four Angophora and Corymbia species were evaluated for their phytochemical profile and efficacy against both primary and secondary pancreatic cancer cell lines. The aqueous leaf extract of Angophora hispida exhibited statistically higher total phenolic content (107.85 1.46 mg of gallic acid equivalents per g) and total flavonoid content (57.96 1.93 mg rutin equivalents per g) and antioxidant capacity compared to the other tested eucalypts (p < 0.05). Both A. hispida and A. floribunda aqueous extracts showed statistically similar saponin contents. A. floribunda extract exerted significantly greater cell growth inhibition of 77.91 4.93% followed by A. hispida with 62.04 7.47% (p < 0.05) at 100 g/mL in MIA PaCa-2 cells with IC

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