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Hadanu R.,Pattimura University | Syamsudin,Pancasila University
Asian Journal of Chemistry | Year: 2013

Quantitative electronic structure-activity relationship (QSAR) analysis of a series of mangostin derivatives as antiplasmodial compounds have been conducted using atomic net charges (q), dipole moment (?) ELUMO, EHOMO, polarizability (a), log P and massa molecular as the descriptors. The descriptors were obtained from computational chemistry method using semi-empirical PM3. Antiplasmodial activities were taken as the activity of the drugs against chloroquine-resistant plasmodiumfalciparum FCR3 strain and are presented as the value of ln (1/IC50) where IC50 is an effective concentration inhibiting 50 % of the parasite growth. The best model of QSAR model was determined by multiple linear regression method and giving equation of QSAR: ln 1/IC50 = -189.029-(752.054) qC5 + (1249.672)qO6 + (3134.359) qC9 + (1174.323) qC10 + (329.121)qC13 -(1.409)? + (75.214) ELUMO -(23.683) ELUMO -(2.156) a-(3.372) log P + (0.309) MM. The equation was significant on the 95 % level with statistical parameters: n = 15; r = 0.951; r2 = 0.905; SE = 1.326498; Fcalc/Ftable = 1.029 and gave the PRESS = 5.650972. Its means that there were only a relatively few deviations between the experimental and theoretical data of antimalarial activity.


Syamsudin,Pancasila University | Simanjuntak P.,Indonesian Institute of Sciences | Djamil R.,Dharmais Cancer Hospital | Heffen W.L.,Pancasila University
American Journal of Biochemistry and Biotechnology | Year: 2010

Problem statement: Propolis has been ethno medically claimed to possess a wide array of biological activities including anticancer activity. The purpose of this research was to verify the folklore claim. Approach: This study was performed in a human breast carcinoma cell, MCF-7. Extract of propolis from different solvent, ethylacetate and n-buthanol showed induced apoptotic cells was detected by flow cytometry. Results: The results demonstrated that ethylacetate extract of propolis can induce apoptosis in MCF-7 as large as 13.21% during the 24 h incubation. On the other hand, doxorubicin is able to induce apoptosis as large as 18.89% during the 24 h incubation. Conclusion: The extracts of propolis ethylacetate had cytotoxic activity and triggers apoptosis on MCF-7 cells. © 2010 Science Publications.


Syamsudin,Pancasila University | Sumarny R.,Pancasila University | Simanjuntak P.,Indonesian Institute of Sciences
European Journal of Scientific Research | Year: 2010

A study was conducted on antidiabetic test of active fractions of methanol extract from Leucaena leucocephala (lmk)DeWit seeds using alloxan-induced rats. Fractionation was conducted on active fractions using column chromatograph. The most active fractions in the previous study were analyzed with thin layer chromatography (TLC) using mobile phase of chloroform-methanol (5:1), chloroform-methanol (2: 1), chloroform-methanolwater (5: 5: 1) on the isolates yielded with oral glucose tolerance test and identification. The result findings show that methanol extracts have a greater antidiabetic activity; and 5 isolates resulted from the isolation of methanol extracts. The result of bioactive compound identification was glycoside compounds with monosaccharide galactose clusters and many other saccharides. It was concluded that active fractions of Leucaena leucocephala (lmk)DeWit seeds had antidiabetic activities and their bioactive compounds constitute glycoside compounds with monosaccharide galactose clusters and many other saccharides. © EuroJournals Publishing, Inc. 2010.


Sutarya D.,National Nuclear Energy Agency BATAN | Mahendra A.,Pancasila University
ICITACEE 2015 - 2nd International Conference on Information Technology, Computer, and Electrical Engineering: Green Technology Strengthening in Information Technology, Electrical and Computer Engineering Implementation, Proceedings | Year: 2016

Hydrogen is increasingly investigated as an alternative energy source to petroleum products in industrial application, internal combustion engines (transportation) and electrical power plant. The safety issues related to hydrogen gas are further exasperated by expensive instrumentation required to measure the temperature, flow rates and production pressure. This paper investigates the use of model based virtual sensors in connection with DEGUSSA Sintering furnace with hydrogen gas as process atmosphere for UO2 pellet sintering processes. The virtual sensors are used to predict relevant hydrogen safety parameters, such as hydrogen output temperature, hydrogen pressure and hydrogen flow rate as a function of different input conditions parameters. The virtual sensors are developed by means of the application of various Artificial Intelligent techniques. To train and appraise the neural network models as virtual sensors, the Degussa sintering system is instrumented with necessary sensors to gather experimental data which together with neural networks and adaptive neuro-fuzzy inference systems were used as predictive tools to estimate hydrogen safety parameters. It was shown that using the neuro-fuzzy inference system, hydrogen safety parameters were predicted with the average RMSE 0.0387, 0.0283, 0.1301 and MAE 0.0241, 0.0115, 0.0355 sequentially for temperature, pressure, and flow rate of hydrogen. © 2015 IEEE.


Faridah,Pancasila University | Natalia,Pancasila University
AIP Conference Proceedings | Year: 2014

Suji (Pleomele angustifolia NE Brown) is one of the medicinal plants of the tribe of Liliaceae, empirically useful to treat coughs and respiratory diseases such as tuberculosis (TB) and pneumonia. In this study, ethanolic extract of suji leaves was tested its activity against bacteria that attacks the respiratory organs, namely Mycobacterium tuberculosis and Streptococcus pneumoniae, using a paper disc diffusion and dilution agar method. These extracts have activity in inhibiting the growth of M. tuberculosis at a concentration of 8 mg and against S. pneumoniae at a concentration of 4 mg. The fractions were tested their antibacterial activity against Streptococcus pneumoniae using paper disc diffusion method. The most active fraction was chosen based on the inhibition diameter. The fractions contained flavonoids, steroids, and essential oils. The precipitate isolated from the extraction process shows needle-shaped, white, cold and tasteless crystals. Moreover, the HPLC analysis of isolate revealed a single peak with a retention time of 7.183 minutes. The exact compounds in the isolate could not be determined but it was known the compounds contained the functional groups of alkene, alkane, C=O, -OH. Test results obtained from UV-Vis spectrophotometer provides maximum absorption at a wavelength of 203.0 nm. © 2014 AIP Publishing LLC.


Abdillah S.,Pancasila University | Tambunan R.M.,Pancasila University | Sinaga Y.M.,Pancasila University | Farida Y.,Pancasila University
Asian Pacific Journal of Tropical Medicine | Year: 2014

Objective: To investigate and collect information from traditional health healer/tribal communities on the use of medicinal plants for treatment of malaria in Sei Kepayang, Asahan District of North Sumatera. Methods: The ethno-botanical study was conducted in Sei Kepayang, Asahan District of North Sumatera in January-March 2013 through questionnaire and personal interviews, and their responses were documented. Results: The present study enumerated 16 ethno-medicinal plant species belonging to 13 families used by the tribal communities and medicinal healers in Sei Kepayang, Asahan District of North Sumatera in treatment of malaria. Some of the recipes, methods of preparation and administration were also documented. Conclusions: From the interviews conducted, 16 plant spesies belonging to 13 families have been identified in the treatment of malaria. © 2014 Hainan Medical College.


Syamsudin,Pancasila University
Research Journal of Pharmacology | Year: 2011

The study aimed at determining the effects of the stem bark extracts of Garcinia parvifolia administered orally to P. berghei infected mice in varied dosages to observe Malondialdehyde (MDA) level, SGOT and SGPT and its relationship with liver cell damage and degree of parasitemia. Thirty mice of Swiss strain used in the experiment were assigned into 5 treatment groups: Group 1 (control group) consisted of P. bergheii infected mice reacted with physiological salt solution; group 2 (normal) consisted of uninfected mice; group 3 consisted infected mice treated with stem bark extracts of G. parvifolia with a dosage of 200 mg/kg BW/day; group 4 consisted of infected mice treated with stem bark extracts of G. parvifolia with a dosage of 400 mg/kg BW/day and group 5 consisted of infected mice treated with stem bark extracts of G. parvifolia with a dosage of 800 mg/kg BW/day. The test preparation was administered orally for 4 days. After 4 days of administration, MDA level was measured in the plasma using a spectrophotometer and three mice were killed to obtain the liver for histopathological purpose. The study found 400 mg kg -1 BW that during malaria infection, MDA production increased and liver damage tended to be milder. Administration of stem bark extract of G. parvifolia in oral way could reduce MDA, SGOT and SGPT level (p<0.05), particularly with a dosage of 400 mg and 800 mg/kg BW/day. © Medwell Journals, 2011.


Syamsudin,Pancasila University
Asian Journal of Chemistry | Year: 2010

In present work, a systematic study of the relative antioxidant activity of Indonesian propolis collected from different regions of Java have been reported. The total phenol varied from 136.2 ± 10.1 to 203.7 ± 9.8 mg g-1 in the extracts. Flavones and flavonols were determined using aluminium chloride and expressed as quercetine equivalent, while flavanones were determined using 2,4-dinitrophenylhydrazine and expressed as naringenin. Contents of flavones and flavonols were similar for most samples and ranged from 1.7-7.3%. The content of flavanones in propolis samples varies from 1.2-5.9%. 1,1-Diphenyl-2-picrylhydrazine (DPPH) radical scavenging effect of the extracts was determined spectrophotometrically. IC50 of the extracts and the standard compounds quercetine was 8.44, 130.35, 19.27, 91.03 and 2.58 μg mL -1.


Rimantho D.,Pancasila University | Cahyadi B.,Pancasila University
ARPN Journal of Engineering and Applied Sciences | Year: 2016

Six Sigma method is one method of management approaches aimed at making decisions based on facts and based on the use of data using special tools and methodologies. This study deals with the methodology of Six Sigma approach in reducing the incidence of occupational accidents in the collection of solid waste in South Jakarta. The fundamental problem-solving approach is done by following the DMAIC (Define-Measure-Analyze-Improve-Control) in order to reduce the process variation and improvement process results. Analysis of the problem also using some tools such as Pareto diagrams, Fishbone diagrams and Analytical Hierarchy Process. Research conducted at the Department of cleanliness of South Jakarta as research subjects in order to analyze and determine the cause of the problem of workplace accidents solid waste collection. Results show DPU approximately 0.22 and approximately 220000 and a target DPMO sigma level is 3.554. Moreover, the results of AHP calculation using Expert Choice software indicate the most significant factor is the method with 0.392 weights. In addition, the sub-causes of the most dominant in workplace accidents collecting solid waste, such as, lack of safety equipment around 0.833 and pleasant environment around 0.833. © 2006-2016 Asian Research Publishing Network (ARPN). All rights reserved.


Syamsudin,Pancasila University
International Journal of Phytomedicine | Year: 2010

Extracts of Leucaena leucocephala (lmk) De Wit seeds were collected from different areas in Java; they include Jakarta, Cengkareng, Bogor and Bandung. Each extract was examined for water content, ash content, acid-insoluble ash content, and α- glycosidase inhibition assay. The results showed that ethanolic extracts of Leucaena leucocephala (lmk) De Wit seeds collected from Bandung were found to be most active in inhibiting the formation of α-glycosidase compounds with an IC50 value of 7,46 ± 0,21 μg/ml, which was confirmed with ash content of 5,58 ± 0,04, acid-insoluble ash content of 0,55 ± 1,33, and water content of 26,22 ± 0,90. ©arjournals.org.

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