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Kusmiati,Indonesian Institute of Sciences | Dhewantara F.X.R.,Pancasila University
Scientia Pharmaceutica | Year: 2016

Glucans are present in fungi, plants, algae, and bacteria. β-Glucan, one of the major cell wall components of Saccharomyces cerevisiae, has been found to enhance immune functions. Glucans are glucose polymers with an α- or β-type glycosidic chain. The role of (1→3)-β-D-glucan is in the maintenance of yeast cell wall shape and rigidity. Studies reveal that soluble glucans can lower total cholesterol and LDL levels in patients with hypercholesterolemia. The important benefit of β-glucan is to improve the immune system and to decrease cholesterol levels in the blood. Several studies have reported the benefits of β-glucan as: antiseptic, antioxidant, anti-aging, immune system activators, protection against radiation, anti-inflammatory, anti-diabetic, anti-cholesterol etc. In this research S. cerevisiae was cultured in yeast extract–peptone–glucose (YPG) broth medium to produce beta-glucan. Cells were harvested at the stationary phase, washed, and disrupted by means of sonication method. The obtained cell walls were used to prepare alkali-soluble β-glucan (glucan-S1). In this regard, 2% sodium hydroxide (NaOH) and 3% acetic acid were used in alkaline–acid extraction, respectively. Potential use of beta-glucan extract as an anticholesterol agent was tested using Sprague dawley strain rats. The experiments were divided into eight groups with four replicates: Group I (normal control), group II (fed with cholesterol without beta-glucan), group III (fed with cholesterol + atorvastatin), group IV (fed with cholesterol + β-glucan standard), group V–VIII (fed of cholesterol + β-glucan of S. cerevisiae with each dose of 10, 20, 30, and 40 mg / BW. Rats were fed with cholesterol for 14 days, except for group I. Analysis of blood was carried out to determine total cholesterol, triglycerides, and malondialdehyde. The results showed that beta-glucan crude obtained from S. cerevisiae cultures was 6.890g.L−1. Βeta-glucan extract of S. cerevisiae can reduce total cholesterol approaching normal values at doses of 10 mg of 32.79 % (blood plasma) and 33.71 % (in the liver). The extract was capable of reducing triglyceride levels in a dose of 10 mg of beta-glucan 64.43 % (blood plasma) and at a dose 30 mg of beta-glucan 19.45 % (liver). Beta-glucan treatment at a dose of 40 mg can reduce MDA levels of 45.22 % (blood plasma) and 42.64 % (liver). © Kusmiati and Dhewantara.


Fitriati D.,Pancasila University | Murtako A.,Pancasila University
2016 International Conference on Informatics and Computing, ICIC 2016 | Year: 2017

Based on data obtained from the Ministry of Indonesia Health in 2012, Diabetes mellitus (DM) was ranked as the sixth leading cause of death. In a higher phase, it can cause complications in other organs such in retina. A disease that attacks the retina is Diabetic Retinopathy (DR). Although it is not a deadly disease, but patient can suffer permanent blindness, which can affect mental and social condition. Therefore built a system that can detect early. So the initial inspection can be faster. This Research uses data from Dr. Cipto Mangunkusumo Hospital (RSCM) Jakarta, Indonesia and DiaretDB0 as comparative data. This research uses knowledge, Fast Adaptive Histogram Equalization as pre-processing method, and Extreme Learning Machine as classification methods from previous research. Feature used is the area of blood vessels. In the previous research, DiaretDB0 reached 97,5%. After that we use these knowledge for RSCM data. But in the experiment, it reached only 52% for testing accuracy, lower than DiaretDB0. The contribution from this research is analysis why the result from both data is different and suggestion for the next research. © 2016 IEEE.


Supriyadi E.,Pancasila University | Kausar D.R.K.,Pancasila University
Journal of Environmental Management and Tourism | Year: 2017

The tourism sector has an important role in the Indonesia economy for the income resources, to create a job and to decrease the poverty. The research objective is to evaluate the factors impact of tourism Indonesia economy and give the government policy to overcome unemployment and poverty. He statements of problem in this research is to answer the current problem in Indonesia to decrease the number of unemployment and poverty through in increasing the tourist sector. Using the econometric model, the relationship among of the variables will have impact to other variable as unemployment, poverty when is given shock to any variable in tourist sector. The result research (1) the increasing consumption price index 10% will increase inbound tourist of Singapore, Australia is followed the expenditure and other impact increasing the poverty and unemployment, cost of hajj. (2) the increasing of the exchange rate 10 % will increase inbound tourist of Malaysia, Japan but decrease from Singapore and Australia and other impact increasing of cost of hajj. (3) the decreasing of rupiah the exchange 10% will increase inbound tourist of Singapore, Australia is followed the expenditure and other impact decreasing the poverty and unemployment. The conclusion is the variables CPI and Exchange rate will give the impact to inbound-tourist, unemployment and poverty which is important for the government’s policy. © 2017. ASERS Publishing. All rights reserved.


Sudiro S.,Pancasila University | Yusof S.M.,University of Kuala Lumpur
Proceedings of the International Conference on Industrial Engineering and Operations Management | Year: 2016

The trend of customer today in many industries is in customized products. The implication to this is in the production floor especially in the assembly plant, where the flow of materials must be managed to ensure that every machine or workstations are supplied with complete materials and volume (quantity), in the right time, so that throughput can be achieved as scheduled. This study is being conducted in a hospital bed industry which uses a special workbench to assemble the beds. This papers outlines the efforts taken to measure production floor performance in the company. The main objective of the study is to define key performance indicators (KPI) of hospital bed production and measures the production floor performance. Using systematic approach to define the main KPIs, resource production capability, valid product definition, production performance as production scheduled and operational performance. Using break down tree analysis for each main KPIs, detail KPIs can then be deploy with the weights of all the KPIs. Based on those KPIs, an instrument(questionnaire) to capture all data need to measure production floor performance was developed. This instrument can be deployed in the production floor to be monitored by the supervisors, and production floor manager. The feed back analysis used value engineering method. The result for production capability, product design definition, production schedule and group production performance showed a level of 3.06, 2.75, by 3.33 and 2.36 for each group performance, and a total performance of 2.92 from a scale of 5. The total level of production performance is below average and the group contributor achieved performance level of below average and average only. This level is far from excellent level performance which require improvement to achieve the level of world class company. © IEOM Society International. © IEOM Society International.


Sembiring H.B.,University of Indonesia | Barus T.,University of Indonesia | Marpaung L.,University of Indonesia | Simanjuntak P.,Indonesian Institute of Sciences | Simanjuntak P.,Pancasila University
International Journal of PharmTech Research | Year: 2015

The purpose of this research was to test antioxidant and antibacterial activity of some leaves extracts of Scurrula fusca G.Don. The antioxidant activity of methanol, ethyl acetate and n-hexane extracts of S. fusca tested by Free Radical Scavenging method using DPPH (1,1-diphenyl-2-picrylhydrazil) are considered very strong since their IC50 value were less than 50 µg/ml (32.96; 27.35 and 40.31 mg/ml respectively). Antibacterial activity test by Disc Difusion method for the extracts showed that methanol extract had activity with category susceptible at concentration of 550 mg/ml against Gram Positive bacteria (Streptococcus aureus and Bacillus cereus) with inhibition zone 17.80 and 18.26 mm respectively, and at the same concentration showed activity with category intermediate against Gram Negative bacteria (Pseudomonas aeruginosa and Escerichia coli). Ethyl acetate extract showed activity with category susceptible at concentration of 450 mg/ml against same Gram Positive bacteria (18.28 mm and 18.05 mm) and activity with category intermediate against Gram Negative bacteria. n-Hexane extract showed activity with category resistant (9.34 - 10.10 mm) against all bacteria tested at concentration of 550 mg/ml. © 2015, Sphinx Knowledge House. All right reserved.


Eddhie J.,Pancasila University
International Journal of Technology | Year: 2017

The mechanical properties and durability of high-performance concrete can be improved with the use of nanosilica. Still, the relationship between the content of nanosilica and the mechanical properties of concrete needs to be verified in order to develop of compressive strength that can be applied to any concrete mixture. The aim of this study was to develop mathematical equations that account for the relationship among concrete's compressive strength, the modulus of elasticity with its compressive strength, and the modulus of rupture with its compressive strength. The specimens of f'c80-NS10-SF5 and f'c100-NS10-SF5 were fabricated by mixing natural nanosilica and silica fume, and those of f'c80-NSHD5-SF5 and f'c100-NSHD5-SF5 were fabricated by mixing commercial nanosilica and silica fume as the main composition materials, with the addition of other materials. The compressive strength and indirect tensile strength of the concrete were tested at 1, 3, 7, and 28 days. New mathematical models of generalized compressive strength against concrete age were empirically developed and then validated in order to derive new insights into the substitution of natural nanosilica for commercial nanosilica in the civil-engineering industry. © IJTech 2017.


Mumpuni E.,Pancasila University | Mulatsari E.,Pancasila University
Asian Journal of Chemistry | Year: 2017

Quantitative structure-activity relationship (QSAR) analysis has been done on derivative compounds of apigenin. Apigenin is one of flavonoid group compound that potential as antioxidant. QSAR analysis was initiated by modelling the structures of compounds and calculating the descriptors of QSAR using Hyperchem software with semiempirical Austin Model 1 (AM 1) method. Determination of QSAR equation has been done using multilinear regression analysis method on one of the statistical data processing software. Of the 18 QSAR equation models, based on the value of R, R2, SE and F obtained 4 QSAR equation models that qualified. The best QSAR equation model determined through the process of validation of the test set compounds. The validation result showed that the best QSAR equation model of the following equation: -log IC50 = 10.035 + (0.997 HOMO energy) + (2.134 LUMO energy) + (-0.045 hydration energy) + (-0.056 log P) + (-0.341 Dipole) + (-3.552 atomic charge of C5) + (4.138 atomic charge of C5′) The results of predicted IC50 on 91 apigenin derivative suggest that the hydration 50 compounds have better biological activity as antioxidant than apigenin and the compound 3,3′,6-triamine apigenin is a compound with the smallest predicted IC50 value (1.76 μM).


Rahmat D.,University of Innsbruck | Rahmat D.,Pancasila University | Sakloetsakun D.,Khon Kaen University | Shahnaz G.,University of Innsbruck | And 3 more authors.
International Journal of Pharmaceutics | Year: 2011

The purpose of this study was to design and characterize a novel cationic thiolated polymer. In this regard a hydroxyethylcellulose-cysteamine conjugate (HEC-cysteamine) was synthesized. Oxidative ring opening with periodate and reductive amination with cysteamine were performed in order to immobilize free thiol groups to HEC. The resulting HEC-cysteamine displayed 2035 ± 162 μmol immobilized free thiol groups and 185 ± 64 μmol disulfide bonds per gram of polymer being soluble in both acidic and basic conditions. Unlike the unmodified HEC, in case of HEC-cysteamine, a three-fold increase in the viscosity was observed when equal volumes of the polymer were mixed with mucin solution. Tablets based on HEC-cysteamine remained attached on freshly excised porcine mucosa for 80 h and displayed increased disintegration time of 2 h. Swelling behavior of HEC-cysteamine tablets in 0.1 M phosphate buffer pH 6.8 indicated swelling ratio of 19 within 8 h. In contrast, tablets comprising unmodified HEC detached from the mucosa within few seconds and immediately disintegrated. In addition, they did not exhibit swelling behavior. The transport of rhodamine 123 across freshly excised rat intestine enhanced by a value of approximately 1.6-fold (p-value = 0.0024) in the presence of 0.5% (m/v) HEC-cysteamine as compared to buffer control. Result from cytotoxicity test of HEC-cysteamine applied to Caco-2 cells in concentration of 0.5% (m/v) revealed 82.4 ± 4.60% cell viability. According to these results, HEC-cysteamine seems to be a promising polymer for various pharmaceutical applications especially for intestinal drug delivery.


Syamsudin,Pancasila University
Asian Journal of Chemistry | Year: 2010

In present work, a systematic study of the relative antioxidant activity of Indonesian propolis collected from different regions of Java have been reported. The total phenol varied from 136.2 ± 10.1 to 203.7 ± 9.8 mg g-1 in the extracts. Flavones and flavonols were determined using aluminium chloride and expressed as quercetine equivalent, while flavanones were determined using 2,4-dinitrophenylhydrazine and expressed as naringenin. Contents of flavones and flavonols were similar for most samples and ranged from 1.7-7.3%. The content of flavanones in propolis samples varies from 1.2-5.9%. 1,1-Diphenyl-2-picrylhydrazine (DPPH) radical scavenging effect of the extracts was determined spectrophotometrically. IC50 of the extracts and the standard compounds quercetine was 8.44, 130.35, 19.27, 91.03 and 2.58 μg mL -1.


Syamsudin,Pancasila University
International Journal of Phytomedicine | Year: 2010

Extracts of Leucaena leucocephala (lmk) De Wit seeds were collected from different areas in Java; they include Jakarta, Cengkareng, Bogor and Bandung. Each extract was examined for water content, ash content, acid-insoluble ash content, and α- glycosidase inhibition assay. The results showed that ethanolic extracts of Leucaena leucocephala (lmk) De Wit seeds collected from Bandung were found to be most active in inhibiting the formation of α-glycosidase compounds with an IC50 value of 7,46 ± 0,21 μg/ml, which was confirmed with ash content of 5,58 ± 0,04, acid-insoluble ash content of 0,55 ± 1,33, and water content of 26,22 ± 0,90. ©arjournals.org.

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