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Ymittos Athens, Greece

Valsamaki P.,Pammakaristos Hospital
Hellenic journal of nuclear medicine | Year: 2010

The second part of this review describes the advantages, and evaluates the radionuclide-guided methods for sentinel lymph node localization and also evaluates the intraoperative application of the blue dye technique in melanoma. By combining the two techniques, the detection rate rises to 96%-98%. The presence of cancer cells in the sentinel node is histopathologically shown by using hematoxylin-eosin and by using sensitive techniques for the detection of micrometastases. Immunohistochemical tech-niques specific for epithelial markers and polymerase chain reaction examination are also applied. Sentinel lymph node biopsy suggests whether regional elective lymphade-nectomy shall be performed. Source


Pipilis A.,Hygeia Hospital | Andrikopoulos G.,Evangelismos Hospital | Lekakis J.,National and Kapodistrian University of Athens | Zavitsanakis P.,Messolongi Hospital | And 8 more authors.
International Journal of Cardiology | Year: 2010

Background: Current guidelines propose different reperfusion strategies for ST-elevation myocardial infarction (STEMI) depending on the time delay from pain onset, the availability of a catheterization laboratory and the patient's characteristics. In order to implement national strategies to improve reperfusion rates the existing situation must be first analysed. The aim of this report is to provide a description of where and when STEMI patients present in a countrywide registry. Methods: The Hellenic Infarction Observation Study (HELIOS) was a countrywide registry that enrolled 1096 patients with STEMI from 31 hospitals with a proportional representation of all types of hospitals from all geographical areas. We recorded the proportion of patients that fits within each category of treatment algorithms. Results: The following percentages of the total STEMI population were recorded: a) admitted in invasive hospitals within 12 h 28.7% (with 26% of those not reperfused) and after 12 h 5.9% and b) admitted in non-invasive hospitals within 3 h 34.9% (with 30% of those not reperfused), 3-12 h 19.3% and after 12 h 11%. Conclusions: A large proportion of STEMI patients are admitted either in an invasive hospital within 12 h or in a non-invasive one within 3 h from pain onset and therefore can be treated locally according to the guidelines. A relatively small percentage of patients are late presenters in non-invasive centres and are candidates for immediate transfer for primary PCI. These data could be useful in planning reperfusion strategies at countrywide level since not all patients may require immediate transfer for primary PCI. © 2008 Elsevier Ireland Ltd. All rights reserved. Source


Papathanassiou M.,National and Kapodistrian University of Athens | Giannoulaki V.,Pammakaristos Hospital | Zampeli E.,National and Kapodistrian University of Athens | Tiligada E.,National and Kapodistrian University of Athens
Journal of Ocular Pharmacology and Therapeutics | Year: 2011

Purpose: Histamine and nitric oxide (NO) play pivotal roles in ocular surface hypersensitivity reactions, whereas the activity of their metabolic enzymes diamine oxidase (DAO) and NO synthase (NOS) may affect their function. This study aimed at investigating the effects of ocular administration of aminoguanidine (AMG), a multiple action DAO and NOS inhibitor, on the conjunctival histamine and nitrite levels in a model of experimental conjunctivitis. Methods: AMG, at 0.81, 81 or 81×103 μM, was instilled into the lower conjunctival fornix of normal and compound 48/80 (C48/80)-challenged eyes of male Wistar rats in the absence or presence of 40mg/mL disodium cromoglycate. Histamine and nitrite were quantified in the conjunctival homogenate and lavage fluid 45min and 6h postchallenge, respectively. Results: AMG induced no significant alterations in basal histamine and nitrite levels in the normal rat eye. In experimental conjunctivitis, AMG failed to modify the reduction in histamine content and partially circumvented the increases in nitrite levels observed during the early and late phase reactions, respectively. In the presence of disodium cromoglycate, AMG significantly increased the levels of both proinflammatory mediators in the normal rat eye. Conclusions: The data suggested that DAO may not be the main route of in situ histamine catabolism in the normal and C48/80-challenged rat conjunctiva, whereas NOS contributes to the phenotypic alterations observed in mast cell-dependent conjunctivitis. Mast cell stabilizing agents and AMG-modulated systems seem to interact through yet undefined mechanisms in the different phases of ocular hypersensitivity reactions. © 2011, Mary Ann Liebert, Inc. Source


Iliopoulos P.,Pammakaristos Hospital | Damigos D.,University of Ioannina | Kerezoudi E.,Pammakaristos Hospital | Limpitaki G.,Pammakaristos Hospital | And 4 more authors.
BMC Research Notes | Year: 2015

Background: Previous studies have shown that common headache triggers contribute to the onset of headache attacks on predisposed individuals and are considered important in the prevention of headache. The aim of this study was to compare the different characteristics of triggers among the most common primary headache subtypes (migraine without aura, migraine with aura and tension type headache). Methods: A total of 116 headache patients of the neurology outpatient department of a tertiary hospital in Athens were selected according to the criteria of the International Classification of Headaches - 3nd Edition Beta. Patients were interviewed using a questionnaire that contained 35 potential trigger factors. Results: The findings showed that migraine and tension-type headache patients report multiple triggers, on a frequent but variable basis. The most frequent triggers reported by all subjects were stressful life events followed by intense emotions. The same applies to both genders, as well as the three headache subgroups. Patients suffering from migraine with aura reported the highest mean number of trigger per person and the highest frequency in almost all the trigger categories. Furthermore, patients with migraine with aura were more likely to report the following triggers: oversleeping, premenstrual period, stressful life events, hot/cold weather, relaxation after stress, menstruation, wind, intense emotions, shining, hunger and bright sunlight. These associations were mostly independent of the sociodemographic characteristics and the presence of anxiety or depressive symptoms. Conclusion: The sensitivity to trigger factors should be considered by both clinicians and headache sufferers. © 2015 Iliopoulos et al. Source

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