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Eindhoven, Netherlands
Eindhoven, Netherlands

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Herremans T.,National Institute for Public Health and the Environment RIVM | Hogema B.M.,Sanquin Blood Supply Foundation | Nabuurs M.,UMCN | Nabuurs M.,Canisius Wilhelmina Hospital | And 18 more authors.
Diagnostic Microbiology and Infectious Disease | Year: 2013

The indirect immunofluorescence assay (IFA) is considered the reference method for diagnosing Q fever, but serology is also performed by complement fixation assay (CFA) or enzyme-linked immunosorbent assay (ELISA). However, comparability between these assays is not clear, and therefore a quality assessment was performed. A total of 25 serum samples from negative controls, Q fever patients, and a serial diluted high-positive sample were analyzed in 10 Dutch laboratories. Six laboratories performed CFA, 5 performed IFA, and 5 performed ELISAs. Three international reference laboratories from Australia, France, and the USA also participated in this study. Qualitative values between laboratories using the same methods were within close range, and all 3 methods correctly identified acute Q fever patients. The IFA, ELISA, and CFA are all suitable serodiagnostic assays to diagnose acute Q fever, but the IFA remains an important tool in the follow-up of patients and in identifying patients at risk for developing chronic Q fever. © 2013 Elsevier Inc..


Dowdle W.E.,University of California at San Francisco | Robinson J.F.,Duke University | Andreas Kneist,RWTH Aachen | Sirerol-Piquer M.S.,CIBER ISCIII | And 18 more authors.
American Journal of Human Genetics | Year: 2011

Nearly every ciliated organism possesses three B9 domain-containing proteins: MKS1, B9D1, and B9D2. Mutations in human MKS1 cause Meckel syndrome (MKS), a severe ciliopathy characterized by occipital encephalocele, liver ductal plate malformations, polydactyly, and kidney cysts. Mouse mutations in either Mks1 or B9d2 compromise ciliogenesis and result in phenotypes similar to those of MKS. Given the importance of these two B9 proteins to ciliogenesis, we examined the role of the third B9 protein, B9d1. Mice lacking B9d1 displayed polydactyly, kidney cysts, ductal plate malformations, and abnormal patterning of the neural tube, concomitant with compromised ciliogenesis, ciliary protein localization, and Hedgehog (Hh) signal transduction. These data prompted us to screen MKS patients for mutations in B9D1 and B9D2. We identified a homozygous c.301A>C (p.Ser101Arg) B9D2 mutation that segregates with MKS, affects an evolutionarily conserved residue, and is absent from controls. Unlike wild-type B9D2 mRNA, the p.Ser101Arg mutation failed to rescue zebrafish phenotypes induced by the suppression of b9d2. With coimmunoprecipitation and mass spectrometric analyses, we found that Mks1, B9d1, and B9d2 interact physically, but that the p.Ser101Arg mutation abrogates the ability of B9d2 to interact with Mks1, further suggesting that the mutation compromises B9d2 function. Our data indicate that B9d1 is required for normal Hh signaling, ciliogenesis, and ciliary protein localization and that B9d1 and B9d2 are essential components of a B9 protein complex, disruption of which causes MKS. © 2011 by The American Society of Human Genetics. All rights reserved.


Homan J.,Radboud University Nijmegen | Bokkerink G.M.,Radboud University Nijmegen | Aarts M.J.,Netherlands Comprehensive Cancer Organization | Lemmens V.E.,Netherlands Comprehensive Cancer Organization | And 6 more authors.
European Journal of Surgical Oncology | Year: 2015

Background Since the introduction of total mesorectal surgery the outcome of rectal cancer patients has improved significantly. Involvement of the circumferential resection margin (CRM) is an important predictor of increased local recurrence, distant metastases and decreased overall survival. Abdomino perineal excision (APE) is associated with increased risk of CRM involvement. Aim of this study was to analyze reporting of CRM and to identify predictive factors for CRM involvement. Methods A population-based dataset was used selecting 2153 patients diagnosed between 2008 and 2013 with primary rectal cancer undergoing surgery. Variation in CRM reporting was assessed and predictive factors for CRM involvement were calculated and used in multivariate analyses. Results Large variation in CRM reporting was found between pathology departments, with missing cases varying from 6% to 30%. CRM reporting increased from 77% in 2008 to 90% in 2012 (p < 0.001). CRM involvement significantly decreased from 12% to 6% over the years (p < 0.001). In multivariate analysis type of operation, low anterior resection or APE, did not influence the risk of CRM involvement. Clinical T4-stage [odds ratio (OR) = 3.51; 95% confidence interval (CI) = 1.85-6.65) was associated with increased risk of CRM involvement, whereas neoadjuvant treatment (5 × 5 gray radiotherapy [OR 0.39; CI 0.25-0.62] or chemoradiation therapy [OR 0.30; CI 0.17-0.53]) were associated with significant decreased risk of CRM involvement. Conclusion Although significant improvements are made during the last years there still is variation in reporting of CRM involvement in the Southern Netherlands. In multivariate analysis APE was no longer associated with increased risk of CRM involvement. © 2015 Elsevier Ltd.


PubMed | PAMM, Netherlands Comprehensive Cancer Organization, Radboud University Nijmegen, Amphia Hospital and Maastricht University
Type: Journal Article | Journal: European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology | Year: 2015

Since the introduction of total mesorectal surgery the outcome of rectal cancer patients has improved significantly. Involvement of the circumferential resection margin (CRM) is an important predictor of increased local recurrence, distant metastases and decreased overall survival. Abdomino perineal excision (APE) is associated with increased risk of CRM involvement. Aim of this study was to analyze reporting of CRM and to identify predictive factors for CRM involvement.A population-based dataset was used selecting 2153 patients diagnosed between 2008 and 2013 with primary rectal cancer undergoing surgery. Variation in CRM reporting was assessed and predictive factors for CRM involvement were calculated and used in multivariate analyses.Large variation in CRM reporting was found between pathology departments, with missing cases varying from 6% to 30%. CRM reporting increased from 77% in 2008 to 90% in 2012 (p<0.001). CRM involvement significantly decreased from 12% to 6% over the years (p<0.001). In multivariate analysis type of operation, low anterior resection or APE, did not influence the risk of CRM involvement. Clinical T4-stage [odds ratio (OR)=3.51; 95% confidence interval (CI)=1.85-6.65) was associated with increased risk of CRM involvement, whereas neoadjuvant treatment (55 gray radiotherapy [OR 0.39; CI 0.25-0.62] or chemoradiation therapy [OR 0.30; CI 0.17-0.53]) were associated with significant decreased risk of CRM involvement.Although significant improvements are made during the last years there still is variation in reporting of CRM involvement in the Southern Netherlands. In multivariate analysis APE was no longer associated with increased risk of CRM involvement.


The newly opened EAST, Miami, a lifestyle hotel & residences at Brickell City Centre and the first U.S. hotel from Swire Hotels’ EAST brand, is hosting a sneak peek of its highly anticipated Art Room during Art Basel Miami. Officially kicking off in January 2017, the EAST, Miami Art Room will showcase a variety of highly recognized and underground local and international art exhibits with innovative programming and rotating pop-up artists in residency throughout the year. “Swire Hotels has always been committed to the arts, investing in local, national and international artist relationships in addition to a longstanding relationship with parent company, Swire Properties, as an official sponsor of Art Basel Hong Kong,” says Brian Williams, Managing Director of Swire Hotels. “With the opening of our first U.S. outpost in Miami this year, we are thrilled to continue to support the fair and arts community worldwide. This is the first Art Basel for EAST, Miami and we are hosting over a dozen of private and public activations throughout the week involving remarkable artists and galleries, including Harif Guzman, Domingo Zapata, Art on Rivington, Art Lexing and The Morrison Gallery Hotel, to name a few.” Originally from Venezuela, 41-year-old celebrated artist Harif Guzman, will be the first artist in residence for two weeks to kick off the 1,050-square-foot Art Room on EAST, Miami’s 7th floor. Entitled “Achilles Armor—​Legend of a Mother’s Love,” the upcoming exhibition was inspired by Guzman’s passion and interest for Greek mythology. The show reflects the personal relationship and synergy between the artist and his own mother. In mythology, the sea nymph Thetis speaks to her son Achilles when he called to her in prayer. She reached out to gods including Zeus and Hephaestus for favors to build a special Armor for Achilles. The intention of this tribute is to illustrate the unbreakable bond between a parent and a child. Guzman’s work will be on display in the Art Room from December 1-4, 2016 for locals and visitors alike.​ The goal of every Swire property is to give back to the community at large. Swire Hotels supports the arts community in Asia and is corporate sponsor of Art Basel Hong Kong. Locally, EAST, Miami is a proud exclusive hotel partner for The National YoungArts Foundation, which identifies and supports the next generation of artists in the visual, literary, design and performing arts; assists them at critical junctures in their educational and professional development; and raises appreciation for the arts in American society. Last month, EAST, Miami began a three-month YoungArts music residency program at the hotel, which highlights a mix of jazz and contemporary tunes. Upon opening in May 2016, the hotel has become the sole official sponsor of the Pérez Art Museum Miami (PAMM) Benefactor Dinner and recently incorporated PAMM private tours and museum tickets as a part of its special ARTEAST hotel package. Most recently, the hotel was the official sponsor of III Points, a three-day music, art and tech festival, founded by Miami visionaries and positioned over the past four years in Wynwood – the rising star of Miami’s modern and artistic urban development. During the festival in October, III Points took over the town with lectures, labs, tech talks, concerts, gallery showcases and a fully immersive five-stage main ground. As part of its partnership, EAST, Miami hosted all talent, from M83 to Redman & Method Man, and incorporated a number of on-premise activations and private after-parties for the festival’s top artists and locals alike. The hotel is the result of a collaboration of world-class architects, interior designers and artists who created an unprecedented multi-dynamic lifestyle experience in the heart of Miami’s financial district. EAST, Miami has already received critical acclaim for its utilization of groundbreaking architecture by Arquitectonica and for its modernist design focused on natural interiors by Clodagh. The 40-story complex also features two distinct destination restaurants and bars, Quinto La Huella and Sugar rooftop bar and garden, designed by the celebrated Studio Collective firm. Staying true to its brand essence, the hotel has exclusively partnered with a number of international and local organizations pertaining to the arts, entertainment, technology, design, beverages and the environment, to benefit its guests and the local community. Next year, curated programming for the hotel’s Art Room may include, but are not limited to collaborations with the following official hotel partners: The National YoungArts Foundation, PAMM, III Points, ART LEXÏNG, Whitelabel and Indiewalls, to name a few. EAST, Miami is Swire Hotels’ first venture into North America, following the openings of EAST in Hong Kong and Beijing. Created for unconventional travelers looking for a fun and relaxing place to stay, EAST, Miami offers distinctive experiences for those seeking innovation, style and personalized service. EAST, Miami offers 352 guest rooms to include eight suites and 89 one-, two- and three-bedroom residence suites (fully equipped apartments with kitchen, laundry facilities and full access to the amenities and services of the hotel). Guests can expect keyless entry, paperless check-in and check-out, a native App with locally curated insights and travel tips, art exhibits, health and wellness programing and array of other happenings to make them feel totally at EAST. The hotel boasts its signature restaurant Quinto La Huella; a poolside bar & lounge and a rooftop destination bar called Sugar; 20,000-square-feet of meeting and banquet rooms with bay and city views; a 20,000-square-foot outdoor pool and deck (with four different pools), which can be used for private events; a lobby café and bar, Domain, and a 24-hour fitness center. Located at 788 Brickell Plaza, Miami, Florida 33131, the hotel is centrally located within a 15-minute drive from the Miami International Airport and situated on top of Brickell City Centre–conveniently connected to popular districts such as Wynwood, the Design District and South Beach. For reservations, please email reservations(at)east-miami(dot)com or call 305-712-7000. For more information, please visit http://www.east-miami.com/.


Jansen S.C.P.,Maxima Medical Center | Groeneveld-Haenen C.P.M.,Maxima Medical Center | Klinkhamer P.J.J.M.,PAMM | Roumen R.M.H.,Maxima Medisch Centrum
BMJ Case Reports | Year: 2015

Merkel cell carcinoma (MCC) is a malignant neuroendocrine carcinoma originating in the skin. It is typically aggressive with a tendency to recur locally and metastasise. There have been several case reports about spontaneous regression of MCC over the past years, but to the best of our knowledge this is the first case of a regional lymph node metastasised MCC with complete spontaneous regression and recurrence. In addition, the primary tumour has an unusual localisation on the foot. © Copyright 2015 BMJ Publishing Group. All rights reserved.


Hiddingh L.,VU University Amsterdam | Raktoe R.S.,VU University Amsterdam | Jeuken J.,PAMM | Hulleman E.,VU University Amsterdam | And 7 more authors.
Scientific Reports | Year: 2014

Drug resistance is a major issue in the treatment of glioblastoma. Almost all glioblastomas are intrinsically resistant to chemotherapeutic temozolomide (TMZ) or develop resistance during treatment. The interaction networks of microRNAs (miRNAs) and mRNAs likely regulate most biological processes and can be employed to better understand complex processes including drug resistance in cancer. In this study, we examined if integrative miRNA/mRNA network analysis using the web-service tool mirConnX could be used to identify drug resistance factors in glioblastoma. We used TMZ-resistant glioblastoma cells and their integrated miRNA/mRNA networks to identify TMZ-sensitizing factors. TMZ resistance was previously induced in glioblastoma cell lines U87, Hs683, and LNZ308. miRNA/mRNA expression profiling of these cells and integration of the profiles using mirConnX resulted in the identification of plant homeodomain (PHD)-like finger 6 (PHF6) as a potential TMZ-sensitizing factor in resistant glioblastoma cells. Analysis of PHF6 expression showed significant upregulation in glioblastoma as compared to normal tissue. Interference with PHF6 expression in three TMZ-resistant subclones significantly enhanced TMZ-induced cell kill in two of these cell lines. Altogether, these results demonstrate that mirConnX is a feasible and useful tool to investigate miRNA/mRNA interactions in TMZ-resistant cells and has potential to identify drug resistance factors in glioblastoma.


PubMed | VU University Amsterdam, PAMM and Massachusetts General Hospital
Type: | Journal: Scientific reports | Year: 2014

Drug resistance is a major issue in the treatment of glioblastoma. Almost all glioblastomas are intrinsically resistant to chemotherapeutic temozolomide (TMZ) or develop resistance during treatment. The interaction networks of microRNAs (miRNAs) and mRNAs likely regulate most biological processes and can be employed to better understand complex processes including drug resistance in cancer. In this study, we examined if integrative miRNA/mRNA network analysis using the web-service tool mirConnX could be used to identify drug resistance factors in glioblastoma. We used TMZ-resistant glioblastoma cells and their integrated miRNA/mRNA networks to identify TMZ-sensitizing factors. TMZ resistance was previously induced in glioblastoma cell lines U87, Hs683, and LNZ308. miRNA/mRNA expression profiling of these cells and integration of the profiles using mirConnX resulted in the identification of plant homeodomain (PHD)-like finger 6 (PHF6) as a potential TMZ-sensitizing factor in resistant glioblastoma cells. Analysis of PHF6 expression showed significant upregulation in glioblastoma as compared to normal tissue. Interference with PHF6 expression in three TMZ-resistant subclones significantly enhanced TMZ-induced cell kill in two of these cell lines. Altogether, these results demonstrate that mirConnX is a feasible and useful tool to investigate miRNA/mRNA interactions in TMZ-resistant cells and has potential to identify drug resistance factors in glioblastoma.


PubMed | Maxima Medisch Centrum, PAMM and Maxima Medical Center
Type: | Journal: BMJ case reports | Year: 2015

Merkel cell carcinoma (MCC) is a malignant neuroendocrine carcinoma originating in the skin. It is typically aggressive with a tendency to recur locally and metastasise. There have been several case reports about spontaneous regression of MCC over the past years, but to the best of our knowledge this is the first case of a regional lymph node metastasised MCC with complete spontaneous regression and recurrence. In addition, the primary tumour has an unusual localisation on the foot.


News Article | November 15, 2016
Site: marketersmedia.com

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