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Burlington, MA, United States

Palomar Medical Technology Inc. | Date: 1996-12-31

applicator for delivery for laser energy in dermatological procedures.

Genina E.A.,Chernyshevsky Saratov State University | Dolotov L.E.,Chernyshevsky Saratov State University | Bashkatov A.N.,Chernyshevsky Saratov State University | Terentyuk G.S.,LLC The First Veterinary Clinic | And 5 more authors.
Quantum Electronics | Year: 2011

A new method for delivering nanoparticles into the skin using the fractional laser microablation of its surface and the ultrasonic treatment is proposed. As a result of in vitro and in vivo studies, it is shown that the 290-nm laser pulses with the energy from 0.5 to 3.0 J provide the penetration of nanoparticles of titanium dioxide with the diameter∼100 nm from the skin surface to the depth, varying from 150 to 400 lm. Histological testing of the skin areas, subjected to the treatment, shows that the particles stay in the dermis at the depth up to 400 lm no less than for three weeks. ©2011 Kvantovaya Elektronika and Turpion Ltd.

Genina E.A.,Chernyshevsky Saratov State University | Titorenko V.A.,Saratov State Medical University | Tuchin V.V.,Chernyshevsky Saratov State University | Simonenko G.V.,Chernyshevsky Saratov State University | And 5 more authors.
Journal of Innovative Optical Health Sciences | Year: 2011

The goal of this work was to evaluate the safety and efficacy of the Red Light Emitted Toothbrush (R-LETB) emitting at wavelength of 663 nm with power density of 3.3 mW/cm2 in combination with 0.1%-methylene blue (MB) solution for the reduction of plaque and treatment of gingivitis. A microbiological in vitro study and a pilot clinical study were conducted. The microbiological study has shown total suppression of pathogenic flora after a 3-min exposure to the dye solution followed by a 20-sec treatment with the R-LETB. For the clinical study, 37 subjects of both sexes with gingivitis were enrolled and randomly assigned to one of two groups. Subjects in the first (treatment) group were instructed to rinse their mouth with MB solution provided for 1 min and then brush the teeth with the R-LETB and standardized toothpaste. The second (control) group used only the toothpaste and a regular toothbrush. Subjects in both groups followed their respective procedures 2 times a day (morning and evening) for 30 days. Indices of plaque, gingival bleeding, and inflammation were evaluated at 14-day and 30-day timepoints. In the both groups, all indices improved in comparison with baseline. However, the treatment group demonstrated more pronounced improvement of the studied indices that was attributed to additional anti-microbial action of red light and MB on gum tissue. Thus, the use of R-LETB with MB appears to have a multifactor therapeutic action on oral pathological microflora: mechanical removal of the bacteria and suppressing action on microorganisms due to photodynamic reaction. © 2011 World Scientific Publishing Company.

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