Pak International Medical College

Peshāwar, Pakistan

Pak International Medical College

Peshāwar, Pakistan
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Jan-i-Alam,Pak International Medical College | Jan S.S.,Saidu Medical College
Journal of Medical Sciences (Peshawar) | Year: 2016

Objectives: To study association of vitamin D deficiency and depressive illness in adults. Material and Methods: The study was conducted in a Private hospital in Hayatabad from May 2015 to December 2015. A total of 340 patients with depression were enrolled in study. Age range was 15 to 70 years. It consisted of equal number of male and female patients i.e. 170 each. Samples of bloods (4ml) were collected from these patients by vanupuncture by disposable syringe after overnight fasting and stored at -18oC. The variables which were studied are age, gender, serum levels of vitamin D, serum Ca levels and history of depression. SPSS-version-10 for windows was used to analyse the study. P value of <0.05 was considered significant statistically. Results: 76% i.e. 258 were vitamin D deficient (cut off value 30 ng/ml). This number comprised 186(72%) females and 72(28%) males. Low serum calcium was observed among 25.5% patients with low vitamin D and depression. Among females 36.8% observed veil (Pardah) and in this group 82% had low serum vitamin D levels. Most of the female patients were from low socio-economic group. Conclusion: Vitamin D deficiency is common in adult patients with depression. © 2016, Khyber Medical College. All rights reserved.


Lutfullah G.,University of Peshawar | Aziz-Ur-Rahman,University of Peshawar | Aziz-Ur-Rahman,Beijing University of Chemical Technology | Ahmad A.,Beijing University of Chemical Technology | And 3 more authors.
Pakistan Journal of Pharmaceutical Sciences | Year: 2017

Present work is aimed to compare the physicochemical characterization and biochemical effects of oil extracted from Silybum Marianum and Sunflower oil, collected from Peshawar (Pakistan). To investigate the comparative effects on the body weight, organ weight and lipid profile, the crude oil of Silybum marianum, edible sunflower oil and vegetable ghee were given to three groups of rabbits under study. Percent proximate composition and food consumption of all rabbits were determined which showed no significant statistical variation. There is no data available about Silybum marianum oil on animal model in literature. This study clearly revealed that oil from Silybum marianum significantly reduces plasma cholesterol level in rabbits. A threefold higher Triglyceride levels was observed in vegetable ghee feeding groups compared with the sunflower and Silybum marianum oil feeding groups. The crude oil of Silybum marianum was found to be safe in rabbits compared with sunflower oil and vegetable ghee. The results of these studies revealed most valuable information and also support the refining and purification to convert this non-edible oil to edible oil.


Nawaz S.,Nowshera Medical College | Rehman S.U.,Khyber Medical College | Nawaz R.,Pak International Medical College | Tariq K.,Khyber Medical College | Khan M.A.,Khyber Medical College
Journal of Medical Sciences (Peshawar) | Year: 2017

Objective: To determine the frequency of Vitamin D deficiency in lactating mothers of infants presenting with rickets Material and Methods: This was a cross sectional descriptive study conducted at Biochemistry Department, Khyber Medical College Peshawar from October 2013 to January 2014. 100 breastfeeding mothers of infants (children beyond neonatal age) with nutritional or vitamin D deficiency rickets were included. Mothers of infants with nutritional rickets fed on formula milk wholly or partially and those with secondary rickets were excluded. Blood samples from mothers were collected in Khyber Teaching Hospital (KTH) and Hayatabad Medical Complex (HMC) Peshawar. All the analyses were performed on Semi-Automatic Clinical Chemistry Analyzer Metrolab 1600. 25-OH Cholecalciferol levels in the serum were determined by ELISA method. Results: Hypovitaminosis D was found in 73% of breastfeeding mothers of infants with rickets. This included 26% of Vitamin D Deficiency and 47% of Vitamin D Insufficiency. Minimum level of 25-OH Vitamin D was 10ng/ml and maximum 58ng/ml with a mean value of 26.94 ng/ml. 71% of mothers with low Vitamin D status belonged to urban areas, 52% were uneducated, 56% were of the highest income group, 42% had a dress preference for being “unveiled” when outdoors, 19% had maximal exposure to sunlight, 73% had no vitamin D supplementation and 86% of such mothers with hypovitaminosis D were housewives. 44% low vitamin D status mothers were either obese or overweight. High serum Alkaline Phosphatase level was associated with hypovitaminosis D in 84% cases, low serum calcium found in 59% and high phosphate in 25% of mothers with low vitamin D status. Conclusion: Breastfeeding mothers of infants with rickets are usually vitamin D deficient/having low vitamin D status. © 2017, Khyber Medical College. All rights reserved.


Nawaz R.,Pak International Medical College | Khan A.S.,Pak International Medical College | Daud B.,Pak International Medical College | Ahmed H.,Pak International Medical College | And 3 more authors.
Journal of Postgraduate Medical Institute | Year: 2017

Objective: To determine the quality assurance of health care services of District Medical & Rehabilitation Complex provided to the people of Charsadda. Methodology: The study design was cross-sectional descriptive and conducted in District Medical & Rehabilitation Center (DMRC) at Charsadda from April 2015 to June 2015. Sample size was 96 by convenient non probability method and included patients visiting DMRC for seeking health care. Data was collected through questionnaires and analyzed in SPSS. Results: Out of 96 patients, there were 47 males and 49 females. Among all patients, 18% were less than 20 year of age, 57% in the age of 20 to 40 years, 16% from 41 to 60 year and 9% were more than 60 years of age. At DMRC, 50.9% of patients visited Eye unit, followed by Gynae unit (15.9%), Medical unit (16%), Psychiatry (8%), Orthopedic (3%) and Physiotherapy (2 %). While waiting for the health care providers, 47% patients waited for less than 30 minutes, 26% patient more than 30 minutes and 28% patients waited almost 1 hour. Regarding responsiveness, 99% patients responded about doctor’s behavior as polite. Regarding expenditures, 40% respondents spent less than Rs. 100 per visit, 41% spent Rs. 100 to Rs. 500 and 19% spent more than Rs. 500. Overall 61% of patients rated their visits as satisfactory. Conclusion: DMRC is providing quality services to the needy people of Charsadda and most of the patients are satisfied with it. © 2017, Postgraduate Medical Institute. All rights reserved.


Faisal R.,Rehman Medical College | Shinwari L.,Lady Reading Hospital | Jehangir T.,Pak International Medical College
Journal of the College of Physicians and Surgeons Pakistan | Year: 2015

Objective: To determine the effect of thymoquinone and methotrexate on blood urea and serum creatinine in arthritic rats. Study Design: Experimental, comparative study. Place and Duration of Study: Postgraduate Medical Institute, Lahore, from March to August 2013. Methodology: Thirty two female Sprague-Dawley rats were randomized into four equal groups (n=8); group A (healthy control), group B (positive control), group C (Thymoquinone treated) and group D (Methotrexate treated). Arthritis developed within two weeks after a single pristane injection. Total leukocyte count, blood urea and serum creatinine were taken at day 0, 15 and 30. While clinical score of inflammation was taken at day 0 and then on every alternate day. Results: Development of arthritis and renal involvement was accompanied by significant raise in total leukocyte count, clinical score of inflammation, blood urea and serum creatinine as compared to healthy control rats (group A) till day 15 (p < 0.001). From day 15 to day 30 both thymoquinone (group C) and methotrexate (group D) significantly lowered the total leukocyte count, clinical score of inflammation and improved blood urea and serum creatinine as compared to arthritic rats (group B) (p < 0.001). Methotrexate was found a bit more effective than thymoquinone. Conclusion: Evaluation of results supported the beneficial effects of thymoquinone in renal injury produced by rheumatoid arthritis.


PubMed | Lady Reading Hospital, Pak International Medical College and Rehman Medical College
Type: Comparative Study | Journal: Journal of the College of Physicians and Surgeons--Pakistan : JCPSP | Year: 2015

To determine the effect of thymoquinone and methotrexate on blood urea and serum creatinine in arthritic rats.Experimental, comparative study.Postgraduate Medical Institute, Lahore, from March to August 2013.Thirty two female Sprague-Dawley rats were randomized into four equal groups (n=8); group A(healthy control), group B (positive control), group C (Thymoquinone treated) and group D (Methotrexate treated). Arthritis developed within two weeks after a single pristane injection. Total leukocyte count, blood urea and serum creatinine were taken at day 0, 15 and 30. While clinical score of inflammation was taken at day 0 and then on every alternate day.Development of arthritis and renal involvement was accompanied by significant raise in total leukocyte count, clinical score of inflammation, blood urea and serum creatinine as compared to healthy control rats (group A) till day 15 (p < 0.001). From day 15 to day 30 both thymoquinone (group C) and methotrexate (group D) significantly lowered the total leukocyte count, clinical score of inflammation and improved blood urea and serum creatinine as compared to arthritic rats (group B) (p < 0.001). Methotrexate was found a bit more effective than thymoquinone.Evaluation of results supported the beneficial effects of thymoquinone in renal injury produced by rheumatoid arthritis.


Inayat A.,Khyber Teaching Hospital | Faisal M.S.,Pak International Medical College | Hayat W.,Khyber Teaching Hospital | Shabbie G.,Khyber Teaching Hospital | Ishtiaq M.,Khyber Medical College
Journal of Medical Sciences (Peshawar) | Year: 2016

Objectives: To assess the prevalence of different complications among hypertensive patients admitted in Medical Intensive Care Units. Material and Methods: This study was conducted in Medical Units and ICU of Khyber Teaching Hospital, Peshawar, Pakistan from September 2014 to February 2015. It was across-sectional study of 219 hypertensive patients, ages between 20 to 70 All the hypertensive patients who had given consent were included and relevant data regarding complications was collected from the patient’s record by means of a structured questionnaire. Results: Most of the patients were males (60.29%) and male to female ratio was approximately 1.5:1, 42.58% had age above 60 years, 11.96% had less than 5 years, 25.36% had more than 10 years, while 62.68% had 5-10 years duration of hypertension. Moreover, 56.45% were obese, 35.4% were smokers, 70.33% had positive history of family hypertension and 59.33% had sedentary life style habits. Out of all hypertensive patients, following complications were noticed; blood vessel (20.57%), cardiac (64.59%), brain (13.88%), renal (29.67%), eye (15.79%) and miscellaneous (67.94%). Conclusion: Effective control of hypertension can reduce the risk of blood vessel, cardiac, brain and renal complications of hypertension. © 2016 Khyber Medical College. All rights reserved.


Nawaz U.,Pak International Medical College | Ilyas N.,WMC | Jehangir A.,IIMC
Medical Forum Monthly | Year: 2014

Objective: To study antihyperlipidemic properties of aqueous extract of Cassia fistula leaves in mice. Study Design: Experimental study. Place and Duration of Study: This study was conducted at Pharmacology Laboratory of Islamic International Medical College, Rawalpindi, and National Institute of Health, Islamabad from February to April 2011. Materials and Method: 40 male Balb/c mice were used which were randomly divided into 4 groups i.e. Group A, B, C and D, each group containing 10 mice. Duration of study was 8 weeks after acclimatization (1 week). Group A served as control group (received standard mice diet), Group B as disease control (received 2% cholesterol diet) and Group C & D as Cassia fistula groups (received 2% cholesterol diet + aqueous extract of Cassia fistula leaves 250 and 500 mg/kg respectively). Results: At the end of 8 weeks, blood samples of all the mice were analyzed. In disease Group B, there was significant rise in the levels of serum total cholesterol, triglycerides and LDL-C and decline in HDL-C. In Group C and D (Cassia fistula groups), there was much less rise in cholesterol, triglycerides and LDL-C especially in Group D. Also, there was significant increase in HDL-C level in group D. Conclusion: The results demonstrate that administration of aqueous extract of Cassia fistula leaves, along with cholesterol diet, not only prevented the rise in serum cholesterol, triglycerides and LDL-C levels but also increased the HDL-C level, demonstrating antihyperlipidemic properties of the extract.


Nawaz R.,Pak International Medical College | Ur Rehman S.,Khyber Medical College | Nawaz S.,Khyber Medical College | Iftikhar B.,Khyber Medical College
Journal of Medical Sciences (Peshawar) | Year: 2015

Objective: To determine toxic heavy metals in red meat samples at Peshawar. Material and Methods: This study was conducted in Peshawar from January 2013 to December 2013. Hundred red meat samples were collected randomly from thirty different union councils of District Peshawar. Samples were transported to the laboratory by keeping in separate plastic bags and kept in refrigerator for processing. In order to detect these metals in various samples, methodology based on the principle of heavy metals that absorb different wavelengths of light is adopted and is termed as flame atomic absorption Spectrophotometer. Results: Mean concentration of Cadmium and Lead in meat samples was 0.107 ug and 2.133 ug respectively. Average concentration of cadmium in buffalo and cow meat was 0.19 ug and 0.14 ug. Average concentration of lead in buffalo and cow meat was 2.52 ug and 1.95 ug. The distribution and concentration of metals varied in different organs of both species. Mean lead concentration in buffalo organ meat was higher than the permissible limits set internationally. Mean mercury concentration was higher in meat of both species. Mean of Cadmium (Cd) concentration in meat samples of both species were below the permissible limits. Conclusion: There is difference in the concentrations of elements across different areas and meat samples from dif­ferent parts and organs of cows and buffalos. This in turn can be related to the origin of organism or food preferences. © 2015, Khyber Medical College. All rights reserved.


Jan-e-Alam,Pak International Medical College | Ul Rashid H.,Khyber Medical College | Wazir A.K.,Nowshera Medical College
Journal of Medical Sciences (Peshawar) | Year: 2016

Objectives: To study deficiency of vitamin “D”and its effects on human body. Material & Methods: The study was conducted in a local private clinic situated in Hayatabad from January 2015 to May 2015. Five hundred subjects were included in the sample which consisted of 250 males and 250 females. These subjects presented to the clinic due to any major or minor illness. These subjects also included those who had or had no body aches. Samples of blood were also collected from these patients by venupuncture by disposable syringe after overnight fasting in mooring. 4 ml of blood sample was taken which was stored at -18°C till the time the sample was analyzed. The variables which were studied are age, gender, serum levels of vitamin “D”, serum calcium levels and past history of any pain in bones. SPSS-version-10 for windows was used to analyse the study. P value of <0.05 was considered to be significant statistically. Results: In 75.5% of the patients included in sample had vitamin “D” deficiency, 9.5% of them were having levels of vitamin “D” within normal range while 15% among the sample patients were in the category of vitamin “D” insufficiency. There was a prevalence of 90.5% of vitamin “D” deficiency and insufficiency overall. 163 (32.6%) patients were presented with the complaints of body aches while remaining 337 (67.4%) patients were having no complaints of body aches. Serum calcium levels were in normal range in all patients which were included in the sample. Conclusion: The dietary insufficiency and lack of exposure to sunlight being the major causes of vitamin D deficiency in humans. © 2016 Khyber Medical College. All rights reserved.

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