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Peshāwar, Pakistan

Nawaz U.,Pak International Medical College | Ilyas N.,WMC | Jehangir A.,IIMC
Medical Forum Monthly

Objective: To study antihyperlipidemic properties of aqueous extract of Cassia fistula leaves in mice. Study Design: Experimental study. Place and Duration of Study: This study was conducted at Pharmacology Laboratory of Islamic International Medical College, Rawalpindi, and National Institute of Health, Islamabad from February to April 2011. Materials and Method: 40 male Balb/c mice were used which were randomly divided into 4 groups i.e. Group A, B, C and D, each group containing 10 mice. Duration of study was 8 weeks after acclimatization (1 week). Group A served as control group (received standard mice diet), Group B as disease control (received 2% cholesterol diet) and Group C & D as Cassia fistula groups (received 2% cholesterol diet + aqueous extract of Cassia fistula leaves 250 and 500 mg/kg respectively). Results: At the end of 8 weeks, blood samples of all the mice were analyzed. In disease Group B, there was significant rise in the levels of serum total cholesterol, triglycerides and LDL-C and decline in HDL-C. In Group C and D (Cassia fistula groups), there was much less rise in cholesterol, triglycerides and LDL-C especially in Group D. Also, there was significant increase in HDL-C level in group D. Conclusion: The results demonstrate that administration of aqueous extract of Cassia fistula leaves, along with cholesterol diet, not only prevented the rise in serum cholesterol, triglycerides and LDL-C levels but also increased the HDL-C level, demonstrating antihyperlipidemic properties of the extract. Source

Shah M.,Hayatabad Medical Complex | Khan M.M.,Hayatabad Medical Complex | Safi T.,Pak International Medical College | Aman A.,Hayatabad Medical Complex | And 3 more authors.
Journal of Medical Sciences (Peshawar)

Objectives: To know the Effectiveness of disc excision in the treatment of herniated lumbar intervertebral disc. Material and Methods: This study was conducted at Neurosurgery Department of Hayatabad Medical Complex, Peshawar. Duration of this study was from March 2014 to September 2014. The study design was descriptive case series in which consecutive non probability sampling technique was used. Results: A total of 62 patients were included with 60% males and 40% females. Mean age was 37 years ± 4.68 SD, 65% patients had L4-L5, 24% patients had L5-S1 and 11% patients had both L4–L5 and L5–S1 level disc herniation. Preoperatively 75% had severe pain, 25% patients had moderate pain. Two weeks postop no pain was found in 85% patients, 12% patients had mild pain while only two patients had moderate pain. No correlation was found between preop pain and postop pain relief. Conclusion: Limited disc excision either through laminectomy, hemilaminectomy or fenestration is a safe, effective and reliable surgical technique for treating properly selected patients of sciatica. Surgical discectomy provides immediate relief from radicular pain than conservative management. Recovery from sciatica make early surgery likely to be cost effective compared with prolonged conservative care. © 2015, Khyber Medical College. All rights reserved. Source

Jan-e-Alam,Pak International Medical College | Ul Rashid H.,Khyber Medical College | Wazir A.K.,Nowshera Medical College
Journal of Medical Sciences (Peshawar)

Objectives: To study deficiency of vitamin “D”and its effects on human body. Material & Methods: The study was conducted in a local private clinic situated in Hayatabad from January 2015 to May 2015. Five hundred subjects were included in the sample which consisted of 250 males and 250 females. These subjects presented to the clinic due to any major or minor illness. These subjects also included those who had or had no body aches. Samples of blood were also collected from these patients by venupuncture by disposable syringe after overnight fasting in mooring. 4 ml of blood sample was taken which was stored at -18°C till the time the sample was analyzed. The variables which were studied are age, gender, serum levels of vitamin “D”, serum calcium levels and past history of any pain in bones. SPSS-version-10 for windows was used to analyse the study. P value of <0.05 was considered to be significant statistically. Results: In 75.5% of the patients included in sample had vitamin “D” deficiency, 9.5% of them were having levels of vitamin “D” within normal range while 15% among the sample patients were in the category of vitamin “D” insufficiency. There was a prevalence of 90.5% of vitamin “D” deficiency and insufficiency overall. 163 (32.6%) patients were presented with the complaints of body aches while remaining 337 (67.4%) patients were having no complaints of body aches. Serum calcium levels were in normal range in all patients which were included in the sample. Conclusion: The dietary insufficiency and lack of exposure to sunlight being the major causes of vitamin D deficiency in humans. © 2016 Khyber Medical College. All rights reserved. Source

Inayat A.,Khyber Teaching Hospital | Faisal M.S.,Pak International Medical College | Hayat W.,Khyber Teaching Hospital | Shabbie G.,Khyber Teaching Hospital | Ishtiaq M.,Khyber Medical College
Journal of Medical Sciences (Peshawar)

Objectives: To assess the prevalence of different complications among hypertensive patients admitted in Medical Intensive Care Units. Material and Methods: This study was conducted in Medical Units and ICU of Khyber Teaching Hospital, Peshawar, Pakistan from September 2014 to February 2015. It was across-sectional study of 219 hypertensive patients, ages between 20 to 70 All the hypertensive patients who had given consent were included and relevant data regarding complications was collected from the patient’s record by means of a structured questionnaire. Results: Most of the patients were males (60.29%) and male to female ratio was approximately 1.5:1, 42.58% had age above 60 years, 11.96% had less than 5 years, 25.36% had more than 10 years, while 62.68% had 5-10 years duration of hypertension. Moreover, 56.45% were obese, 35.4% were smokers, 70.33% had positive history of family hypertension and 59.33% had sedentary life style habits. Out of all hypertensive patients, following complications were noticed; blood vessel (20.57%), cardiac (64.59%), brain (13.88%), renal (29.67%), eye (15.79%) and miscellaneous (67.94%). Conclusion: Effective control of hypertension can reduce the risk of blood vessel, cardiac, brain and renal complications of hypertension. © 2016 Khyber Medical College. All rights reserved. Source

Faisal R.,Rehman Medical College | Shinwari L.,Lady Reading Hospital | Jehangir T.,Pak International Medical College
Journal of the College of Physicians and Surgeons Pakistan

Objective: To determine the effect of thymoquinone and methotrexate on blood urea and serum creatinine in arthritic rats. Study Design: Experimental, comparative study. Place and Duration of Study: Postgraduate Medical Institute, Lahore, from March to August 2013. Methodology: Thirty two female Sprague-Dawley rats were randomized into four equal groups (n=8); group A (healthy control), group B (positive control), group C (Thymoquinone treated) and group D (Methotrexate treated). Arthritis developed within two weeks after a single pristane injection. Total leukocyte count, blood urea and serum creatinine were taken at day 0, 15 and 30. While clinical score of inflammation was taken at day 0 and then on every alternate day. Results: Development of arthritis and renal involvement was accompanied by significant raise in total leukocyte count, clinical score of inflammation, blood urea and serum creatinine as compared to healthy control rats (group A) till day 15 (p < 0.001). From day 15 to day 30 both thymoquinone (group C) and methotrexate (group D) significantly lowered the total leukocyte count, clinical score of inflammation and improved blood urea and serum creatinine as compared to arthritic rats (group B) (p < 0.001). Methotrexate was found a bit more effective than thymoquinone. Conclusion: Evaluation of results supported the beneficial effects of thymoquinone in renal injury produced by rheumatoid arthritis. Source

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