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Terrasson-Lavilledieu, France

Dongho Dongmo F.F.,University of Douala | Ngono Ngane R.A.,University of Douala | Gouado I.,University of Douala | Pankoui Mfonkeu J.B.,University of Douala | And 4 more authors.
African Journal of Biotechnology | Year: 2011

The physiopathology of malaria is complex. More understanding would be useful for a better management of the disease. This study was undertaken to describe clinical presentation and some biochemical parameters in childhood malaria in order to identify some factors of disease severity. Eighty six (86) children (0 to 15 years old) were recruited in Douala, clinical data recorded and blood sample collected. Thirty one (31) healthy children were also targeted to serve as control. Blood glucose, hemoglobin, transaminases and nitric oxide were determined by spectrophotometry. C reactive protein (CRP) was also investigated. The results confirmed that severe malaria significantly affects children under 5 years. Severe malaria was associated with hyperpyrexia and prostration. Coma, convulsions and unconsciousness were more indicative of cerebral malaria. Hemoglobin and blood glucose levels decreased significantly in severe malaria patients compared with uncomplicated malaria patients or controls (P < 0.001). On the contrary, blood transaminases and CRP levels increased significantly in malaria patients compared to controls (P < 0.001). From these results, it is clear that childhood severe malaria is associated with prostration, coma, unconsciousness, convulsions and hyperpyrexia. Low levels of haemoglobin and glycemia, as well as high levels of transaminases and CRP has been identified as predictor of malaria severity. © 2011 Academic Journals.

Pankoui Mfonkeu J.B.,University of Douala | Gouado I.,University of Douala | Fotso Kuate H.,Laboratory Service | Zambou O.,Paediatric service | And 3 more authors.
British Journal of Nutrition | Year: 2010

To investigate the part played by undernutrition in malaria severity, some biomarkers of nutritional status were assessed in children with severe malarial anaemia (MA) and cerebral malaria (CM) in comparison with healthy children or those with uncomplicated malaria. Undernutrition was assessed using the weight-for-age Z score (WAZ). Retinol was determined by HPLC; lipid profile, Ca, Mg and albumin were determined by spectrophotometry. Severe and moderate undernutritions were more prevalent in children with MA and those with the combined symptoms of CM and MA, but not in those with CM alone. Some perturbations were noticed in the lipid profile, but most of the values remained within the normal ranges. The risk of vitamin A deficiency, as assessed by plasma retinol concentration, was noteworthy in children with severe malaria: 048106 and 050106mol/l, respectively, in children with MA and CM (reference value: >07106mol/l). A significant difference was obtained for retinol values after an ANOVA of all the groups (P=00029), with the value in the MA group being significantly low than that in the control group (P<005); likewise, a significant difference was obtained after comparison of all the groups for Mg and albumin (P=00064 and 00082, respectively). Despite their low number (n 6), fatal cases of CM had a normal mean WAZ on admission, but low values of retinol, albumin and HDL:LDL ratio. Despite these associations, undernutrition itself did not appear to be a primary factor associated with fatal outcome. Copyright © The Authors 2010.

Kasmi G.,University of Tirana | Andoni R.,University of Tirana | Mano V.,University of Tirana | Kraja D.,Infectious Diseases | And 2 more authors.
Clinical Laboratory | Year: 2011

S. bovis is known for causing bacteremia and endocarditis as well as accompanying malignant diseases of the gastrointestinal tract [1,2]. Hence, identification of this species and recognition of the clinical characteristics of infections caused are essential for both therapy and prognosis. S. bovis isolated from haemoculture requires an immediate search for gastrointestinal tract lesions.

Aguayo A.,Cruces University Hospital | Aguayo A.,Spanish Biomedical Research Center in Diabetes and Associated Metabolic Disorders | Vela A.,Cruces University Hospital | Vela A.,Spanish Biomedical Research Center in Diabetes and Associated Metabolic Disorders | And 13 more authors.
Journal of Pediatric Endocrinology and Metabolism | Year: 2013

Background: The worldwide epidemic of childhood obesity has been accompanied by an increase in the incidence of carbohydrate metabolism disorders. Objective: To determine the prevalence of type 2 diabetes mellitus (T2DM) and other carbohydrate metabolism disorders in obese young people in the Basque Country (Spain). Design: Prospective observational study. Patients: We studied 136 obese Caucasian children and adolescents (body mass index ≥2 SDS above the mean). Measurements: Their severity of obesity was classified as mild <3 SDS or moderate-to-severe ≥3 SDS. Data were collected on clinical and metabolic parameters; insulin resistance (IR) was calculated using the homeostasis model assessment, and an oral glucose tolerance test (OGTT) was carried out. Results: T2DM was not found. Impaired glucose tolerance (IGT) was found in 9.6% of patients being higher in moderate-to-severe obesity (12.8% vs. 2.4%; p=0.048) and in patients with acanthosis nigricans (27.8% vs. 6.8%; p=0.016). No differences were detected by sex or pubertal development in metabolic results as a function of OGTT's response. IR (13.5%) was higher among those with moderate-to-severe obesity, in patients with acanthosis nigricans and was associated with other cardiovascular disease risk factors. Conclusions: We found no children with T2DM. The prevalence of IGT and IR was related to severity of obesity, to the association of acanthosis nigricans and was associated with cardiovascular risk.

Isacco L.,University Blaise Pascal | Lazaar N.,University Blaise Pascal | Ratel S.,University Blaise Pascal | Thivel D.,University Blaise Pascal | And 4 more authors.
Child: Care, Health and Development | Year: 2010

Background Obesity is increasing worldwide, reaching alarming proportions. Eating habits have changed over time and nowadays children and adolescents' environment favours the adoption of unhealthy eating behaviours leading to metabolic impairment.Objective To explore the impact of eating risk factors and their cumulative effect on anthropometric characteristics in French primary school children.Methods A total of 278 healthy French children (7.50 ± 0.67 years old) and their legal representatives agreed to take part in this study. Parents were asked to fill in an eating habits clinical questionnaire with questions about skipping breakfast, snacking between meals, eating in front of the TV and sugar-sweetened beverage consumption. On the basis of the answers, children were classified into four categories as a function of the number of eating risk factors they presented. Body mass index (BMI), the sum of four skinfolds (Σ4 skinfolds: tricipital, bicipital, sub-scapular and supra-iliac) and waist circumference (WC) were measured. BMI was transformed into z-BMI for each child.Results anova and unpaired t-test provided significantly higher z-BMI, Σ4 skinfolds and WC in children who were used to skipping breakfast, snacking, watching TV while eating and consuming sugar-sweetened beverages. The more children accumulated eating risk factors, the higher were their z-BMI, Σ4 skinfolds and WC (manova: P < 0.001).Conclusions Eating habits appear to be associated with anthropometric characteristics in French primary school children. Anthropometric values (z-BMI, Σ4 skinfolds and WC) increased with the number of eating risk factors they presented. © 2010 Blackwell Publishing Ltd.

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