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Chitlange S.S.,Padmdr D Y Patil Institute Of Pharmaceutical Science And Research | Pawbake G.R.,Padmdr D Y Patil Institute Of Pharmaceutical Science And Research | Mulla A.I.,Padmdr D Y Patil Institute Of Pharmaceutical Science And Research | Wankhede S.B.,Padmdr D Y Patil Institute Of Pharmaceutical Science And Research
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2010

The present work describes a stability-indicating HPTLC method for analysis of diacerein in bulk and pharmaceutical dosage form. Precoated silica gel 60 F 254 plate was used as stationary phase. The separation was carried out using toluene: isopropyl alcohol: ammonia (4.6:4.6:0.8 %v/v/v) as mobile phase. The densitometric scanning was carried out at 258 nm. The Rf value for the drug was found to be 0.30±0.01. The linearity was obtained in the range 100-350ng/band (r 2 = 0.9909). The method was validated as per ICH guidelines. Diacerein was subjected to forced degradation by acid, alkali, oxidation and dry heat. The degradation products were well resolved from the pure drug with significantly different Rf values. Source

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