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Ahmadnagar, India

Gholap S.S.,Padmashri Vikhe Patil College
European Journal of Medicinal Chemistry | Year: 2016

Pyrrole derivatives comprise a class of biologically active heterocyclic compounds which can serve as promising scaffolds for antimicrobial, antiviral, antimalarial, antitubercular, anti-inflammatory and enzyme inhibiting drugs. Due to their inimitable anticancer and anti-tubercular properties, researchers were inspired to develop novel pyrrole derivatives for the treatment of MDR pathogens. In the present review the main target is to focus on the development of pyrrole mimics, with emphasis based on their structure activity relationship (SAR). The present review is being obliging for the future development of pyrrole therapeutics. © 2015 Elsevier Masson SAS. Source


Gopal Reddy P.,Padmashri Vikhe Patil College | Tathe P.,Padmashri Vikhe Patil College
Biochemical and Cellular Archives | Year: 2012

The objective of the study was to evaluate the effect of different concentrations of aqueous as well as ethanolic leaf extracts of W. fruticosa on the growth of five bacteria viz., Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa and Salmonella typhimurium. Both extracts inhibited the bacterial growth however leaves extracted in alcohol exhibited greater antibacterial activity. Comparatively K. pneumoniae is inhibited more while S. typhimurium and P. aeruginosa less. Source


Kundlik M.L.,Padmashri Vikhe Patil College | Zaware B.H.,Commerce and Science College | Kuchekar S.R.,Padmashri Vikhe Patil College
Bulgarian Chemical Communications | Year: 2010

A high-throughout bioanalytical method based on a solid phase extraction (SPE) and rapid liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis has been developed and validated for the quantification of tamosulosin in heparinzed human plasma. Plasma samples, without a drying and reconstitution step, were extracted by a simple SPE. The analytes and tamosulosin D4 isotope (internal standard, IS) were chromatographed on a Betabasic-8 column. The total chromatographic run time was 1.8 min per sample. The response was a linear function of concentration in the range of 0.075-50.0 ng/ml, with correlation coefficient ≥0.9992. The assay has excellent characteristics and was successfully applied to bioequivalence study samples for estimation of tamosulosin in healthy human subjects. © 2010 Bulgarian Academy of Sciences, Union of Chemists in Bulgaria. Source


Kuchekar S.R.,Padmashri Vikhe Patil College | Kundlik M.L.,Padmashri Vikhe Patil College
Journal of Saudi Chemical Society | Year: 2011

A high-throughout bioanalytical method based on a solid-phase extraction (SPE), and rapid liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis has been developed and validated for the quantification of mirtazapine (MRT) and desmethyl mirtazapine (DMRT) in heparinized human plasma. Plasma samples, without a drying and reconstitution step, were extracted by a simple SPE. The analytes and imipramine (internal standard, IS) chromatographed on a Betasil-C18 column. The total chromatographic run time was 1.8. min per sample. Response was a linear function of concentration in the range 0.1-100.0. ng/ml, with correlation coefficient ≥0.9994. The assay has excellent characteristics and has been successfully applied to bioequivalence study samples for estimation of MRT and DMRT in healthy human subjects. © 2010. Source


Kundlik M.L.,Padmashri Vikhe Patil College | Kuchekar S.R.,Padmashri Vikhe Patil College
Journal of Chromatographic Science | Year: 2012

A rapid liquid chromatographic method with electrospray ionization tandem mass spectrometric (LCMSMS) detection is developed and validated for quantification of glimepiride in heparinized human plasma. Plasma samples, without a drying and reconstitution step, are extracted by solid-phase extraction (SPE) and eluted with 0.9 mL of acetonitrilemethanol (1:1, v/v) containing 0.05 formic acid. The analyte and glimepiride d8 (internal standard, IS) are chromatographed on a C18 column; the mobile phase is acetonitrile2 mm ammonium formate (88:12, v/v), with the pH adjusted to 3.5 with formic acid, at a flow rate of 0.5 mL/min. The retention times of glimepiride and the IS are 0.93 min, and the runtime is 1.6 min per sample. Selected reaction monitoring of MH+ at m/z 491.20 and 499.26 result in stable fragment ions with m/z 351.80 and 359.96 for glimepiride and the IS, respectively. The response was a linear function of the concentration in the range of 2.0650.0 ng/mL, with r < 0.9994. The recovery of glimepiride and the IS ranged from 81.91 to 83.36. The assay has excellent characteristics and has been successfully used for the analysis of glimepiride in healthy human subjects in a bioequivalence study. It was well suited to clinical studies of the drug involving large numbers of samples. © 2011 The Author. Source

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