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Chitlange S.S.,Padmashri Dr Dy Patil Institute Of Pharmceutical Science And Research | Mulla A.I.,Padmashri Dr Dy Patil Institute Of Pharmceutical Science And Research | Pawbake G.R.,Padmashri Dr Dy Patil Institute Of Pharmceutical Science And Research | Wankhede S.B.,Padmashri Dr Dy Patil Institute Of Pharmceutical Science And Research
Preparative Biochemistry and Biotechnology | Year: 2010

A stability-indicating thin layer chromatographic (TLC) method for determination of dexrabeprazole (DEX) and domperidone (DOM) in combined dosage form has been developed and validated. The mobile phase selected was acetone:toluene:methanol (4.5:4.5:0.5, v/v/v) with ultraviolet (UV) detection at 285nm. The retention factors for DEX and DOM were found to be 0.49±0.02 and 0.24±0.03, respectively. The method was validated with respect to linearity, accuracy, precision, and robustness. The linearity range for DEX was 50-350ng/band (r 2=.9960) and for DOM was 100-700-n /band (r 2=.9982), respectively. The method was successfully applied for the analysis of drugs in pharmaceutical formulation. Copyright © Taylor & Francis Group, LLC. Source

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