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Sahasrabudhe T.,Padmashree Dr D Y Patil Medical College
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2012

Prophylactic pyridoxine is routinely prescribed to patients on TB chemotherapy to prevent Isoniazid induced neuropathy. The study aimed to determine the incidence of peripheral neuropathy in Indian patients on daily TB chemotherapy without prophylactic pyridoxine and whether they really needed therapeutic doses of pyridoxine, if it occurred. 559 patients on TB chemotherapy as per WHO categorization without prophylactic pyridoxine were followed throughout the course of treatment. Patients with proven or suspected drug resistance, those with existing peripheral neuropathy or those suffering from a condition predisposing to neuropathy such as diabetes were excluded. Patients reporting with symptoms of peripheral neuropathy were followed. Other causes of neuropathy were ruled out. They were given daily vitamin B-complex for one week. 100 mg daily pyridoxine was given only if there was no adequate response. A total of 26/559 patients (4.65%) developed neuropathy symptoms. 19/26 (73.07%) patients responded to one week course of B-complex and never had recurrence of symptoms. 7/559 (1.25%) patients needed 100 mg of pyridoxine to relieve their symptoms. This study indicates very low incidence of peripheral neuropathy in patients on daily TB chemotherapy without use of prophylactic pyridoxine, in Indian scenario. Not all patients developing neuropathy need high dose pyridoxine.

Choudhury I.,Padmashree Dr D Y Patil Medical College | Patra A.K.,AFMC
Indian Journal of Clinical Biochemistry | Year: 2012

Hypertension, a well known risk factor for various cardiovascular, peripheral vascular and renal events is an important public health challenge. Renin angiotensin system (RAS) being the most vital pathogenic mechanism of hypertension is mediated by a key component; the angiotensin converting enzyme (ACE). The present study was aimed to know the relationship of ACE gene polymorphism and the possible risk of development of hypertension in south Indian population. The study included 101 clinically diagnosed hypertensive patients without any associated disease condition and 81 age and sex matched apparently healthy controls. Genotyping was performed using a polymerase chain reaction, (PCR) amplification of the intron 16 fragment harboring the 287 bp Alu repeat sequence. Three possible genotypes D/D, I/I homozygous and I/D heterozygous were analyzed where the D/D genotypes corresponds to higher ACE levels (D-Deletion, I-Insertion). The PCR products were separated on 2 % agarose gel. Statistical analysis was performed using SPSS.15 software program. We found a significance in frequency of D/D genotype in the hypertensive patients compared to the control group (p = 0.0005, odd's ratio = 4.157). This suggested that ACE (D/D) genotypes are more prone for the development of hypertension. This is relatively a pilot study; but nevertheless may assist in identifying the pathophysiological cause of hypertension. © Association of Clinical Biochemists of India 2012.

Pinto V.,Padmashree Dr D Y Patil Medical College
Journal of Natural Science, Biology and Medicine | Year: 2013

The global events of the last two decades indicate that the threat of biological warfare is not a myth, but a harsh reality. The successive outbreaks caused by newly recognized and resurgent pathogens and the risk that high-consequence pathogens might be used as bioterrorism agents amply demonstrate the need to enhance capacity in clinical and public health management of highly infectious diseases. This review article provides a concise overview of bioterrorism, the agents used, and measures to counteract it, with a relevant note on India′s current scenario of surveillance systems, laboratory response network, and the need for preparedness.

Jadhav A.,Padmashree Dr D Y Patil Medical College | Borade N.G.,Padmashree Dr D Y Patil Medical College | Jadhav A.,Bharati Vidyapeeth Medical College | Pranita A.,Bharati Vidyapeeth Medical College
Indian Journal of Public Health Research and Development | Year: 2014

Background: Intense physical activity in the form of strenuous exercise causes more oxygen consumption and more free radical production termed as oxidative stress,which is in the form of increased by products of lipid peroxidation (increased MDA levels) as the intensity and duration of exercise was more. On the other hand in other study it was found that endurance training reduced MDA level which is a byproduct of lipid peroxidation. The present study is designed to see the effect of "Aerobic strenuous exercise" on oxidative stress in young healthy individuals over a period of six months. Materials & Method: The present study was undertaken 32 male individuals practicing aerobic strenuous exercise. Aerobic moderate to severe type of exercise given on bicycle ergometer. Pulse rate was used as an indicator of severity of exercise. Serum Malonyldialdehyde (MDA) was estimated as an index of lipid peroxidation. Result: There is statistically significant increase in average serum MDA values between the before & after 3 months of Aerobic strenuous exercise training.(p<0.05).Also there is statistically highly significant (p<0.001) decrease in average serum MDA values between before and after the 6 months of aerobic strenuous exercise training. Conclusions: Awareness about the effects of short term exercise and long term endurance exercise should be spread amongst all the individuals joining these types of exercise schedules at various centers. They should be encouraged for long endurance exercises for most beneficial effects on the body. © 2014, Indian Journal of Public Health Research and Development. All rights reserved.

Dubhashi S.P.,Padmashree Dr D Y Patil Medical College | Trinath T.,Padmashree Dr D Y Patil Medical College
Journal International Medical Sciences Academy | Year: 2013

Obesity is an established risk factor for gall stone disease. Male sex has also been recently cited as a risk factor for severe symptomatic cholelithiasis. As a possible cause of several difference in regards to the severity of cholecystitis, many physiological differences between the two sexes can be examined. It is postulated that the total body fat, the main value of which is significantly higher for females than males, may contribute to this sex difference. To study the association between body mass index and severity of cholecystitis. This is a prospective study carried out on 70 patients for cholecystitis whose weight and height measurements had been recorded on admission. Patients were placed in either group -Obese (BMI e 25kg/m2) or Non-Obese (BMI < 25kg/m2). The association between BMI and severity of cholecystitis was investigated. Of the 70 patients included in the study, 47 patients (67.14%) were chronic cases of cholecystitis, 16 cases (22.85%) were diagnosed as acute cholecystitis and complicated acute cholecystitis was seen in 7 patients (10%). Among the complicated cases, empyema was noted in 4 patients and peri-cholecystic abscess in 2 patients. 42 patients (60%) of the 70 patients who were studied were obese and 28 patients (40%) were non-obese. In case of males, the proportion of complicated acute cholecystitis was higher in non-obese patients (20%) compared with obese patients (9%). The results were statistically significant (p<0.05). In case of females, there is no significant difference in proportion of complicated acute cholecystitis in obese and non-obese patients. BMI was found to be negatively correlated with the severity of cholecystitis in males, resulting in higher incidence of severe cholecystitis in the non-obese male patients.

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