Padmashree Dr D Y Patil Institute Of Pharmaceutical Science And Research

Pimpri, India

Padmashree Dr D Y Patil Institute Of Pharmaceutical Science And Research

Pimpri, India
SEARCH FILTERS
Time filter
Source Type

Vidyasagar N.,Padmashree Dr D Y Patil Institute Of Pharmaceutical Science And Research | Nanda R.,Padmashree Dr D Y Patil Institute Of Pharmaceutical Science And Research | Mangal R.,Padmashree Dr D Y Patil Institute Of Pharmaceutical Science And Research
Synthetic Communications | Year: 2012

Efficient syntheses of xanthenes have been described using a catalytic amount of perchloric acid in water. The high temperature and lengthy reaction time normally required for formation of xanthenes derivatives are not necessary when using a catalytic amount of perchloric acid. The method is relatively inexpensive, easily available, nonvolatile, nonexplosive, and thermally robust to catalyze the reaction at 80° C by simple heating with good to excellent yields. The advantages of the reaction involve simple reaction protocol, simple workup, and improved synthesis in the presence of perchloric acid as catalyst. © 2012 Taylor & Francis Group, LLC.


Dongre P.R.,Padmashree Dr D Y Patil Institute Of Pharmaceutical Science And Research | Bhujbal S.S.,Padmashree Dr D Y Patil Institute Of Pharmaceutical Science And Research | Kumar D.,University Of Kashmir | Kumar D.,CSIR - Central Electrochemical Research Institute
Oriental Pharmacy and Experimental Medicine | Year: 2015

Curcuma longa, Zingiber officinale and Alpinia galanga are traditionally and scientifically reported for the treatment of respiratory disorders such as asthma, bronchial congestion and allergic reactions in respiratory tract. As part of a continuing effort aimed at the development of efficacious bronchodilator and anticataleptic herbal formulation for the treatment of asthma and related respiratory diseases. We have formulated herbal capsules (AHF) using Curcuma longa, Zingiber officinale and Alpinia galanga extracts. In this report, we have focused on the evaluation of AHF for bronchodilatory potential. AHF was studied on clonidine induced mast cell degranulation and OVA albumin induced airway inflammation model at the doses of 62.5,125 and 250 mg/kg. AHF at dose of 250 mg/kg showed significant protection of mast cell degranulation (40%) as compared to standard sodium cromoglycate (64%) while at doses of 62.5, 125, 250 mg/kg showed marked inhibition of total cells, eosinophils, neutrophils, lymphocytes, whereas in case of macrophages and monocytes an inhibition was observed at 125, 250 mg/kg along with the inhibition of IgE. The findings revealed that the bronchodilatory activity of AHF may be due to the mast cell stabilizing potential, suppression of IgE, and inhibition of release of inflammatory mediators. © 2015, Institute of Korean Medicine, Kyung Hee University and Springer Science+Business Media Dordrecht.


Ganu G.,Padmashree Dr D Y Patil Institute Of Pharmaceutical Science And Research | Garud A.,Padmashree Dr D Y Patil Institute Of Pharmaceutical Science And Research | Agarwal V.,Padmashree Dr D Y Patil Institute Of Pharmaceutical Science And Research | Suralkar U.,Padmashree Dr D Y Patil Institute Of Pharmaceutical Science And Research | And 2 more authors.
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2011

Mimusops elengi Linn (Sapotaceae) commonly known as Bakul, is a small to large evergreen tree. It is cultivated in gardens as an ornamental tree. Bark is used as a tonic, febrifuge, against odontopathy, inflammation. The part of plants was used in Thai traditional as rejuvenating and neuro tonic remedies, also Mimusops elengi is being screened for acetyl cholinesterase inhibitory activity. Despite the widespread uses of the plant, no scientific work is reported in literature regarding the effect of Mimusops elengi bark against anxiety like states therefore, the present study evaluates the anti-anxiety activity of methanolic, aqueous and n-butanol extract of bark of Mimusops elengi using elevated plus maze in swiss albino mice. Different doses of Test extract was evaluated in animals. Methanol extract at 50,100 and 200 mg/kg, aqueous extract at 100 and 200 while n-butanol extract at 200 mg/kg in mice were active but methanolic extract at 200 mg/kg was found to have more significant anxiolytic activity as compared to aqueous and n-butanol extract. Also activity of methanolic extract at 200 mg/kg was comparable with diazepam.


Kothapalli L.P.,Padmashree Dr D Y Patil Institute Of Pharmaceutical Science And Research | Choudhari M.E.,Padmashree Dr D Y Patil Institute Of Pharmaceutical Science And Research | Thomas A.B.,Padmashree Dr D Y Patil Institute Of Pharmaceutical Science And Research | Nanda R.K.,Padmashree Dr D Y Patil Institute Of Pharmaceutical Science And Research | And 2 more authors.
Der Pharma Chemica | Year: 2012

Ropinirole hydrochloride is a nonergot dopamine agonist, indicated for the treatment of the signs and symptoms of Parkinson' disease. The objective of this study is to develop validated HPLC (Method-I) and first order derivative spectrophotometric method (Method -II) for the estimation of ropinirole hydrochloride. A sharp peak of the drug was obtained at 2.66 min, on a Thermo C 18 column (4.6 mm i.d × 250 mm) utilizing Acetonitrile: 0.02 M KH 2PO 4 solution in the ratio 72:28 v/v as mobile phase. The flow rate was 1.1 mL/min with UV detection at 250.0 nm. The methods are validated for specificity, precision, accuracy and robustness. Method -II is a simple, precise and economical first order derivative method for the estimation of ropinirole hydrochloride from its formulation. Ropinirole hydrochloride shows absorption maxima at 249.0 nm and in the first order derivative spectra, zero crossing at 249.0 nm was obtained with a sharp peak at 238.0 nm when n = 1. Results of the analysis were validated statistically and were found to be satisfactory.


Nanda R.K.,Padmashree Dr D Y Patil Institute Of Pharmaceutical Science And Research | Kulkarni A.A.,Padmashree Dr D Y Patil Institute Of Pharmaceutical Science And Research | Yadav P.B.,Padmashree Dr D Y Patil Institute Of Pharmaceutical Science And Research
Der Pharma Chemica | Year: 2011

Two simple, sensitive, rapid spectrophotometric methods have been developed for simultaneous estimation of Atazanavir Sulfate (ATV) and Ritonavir (RTV) in tablets. First method involves solving simultaneous equations based on measurement of absorbance at two wavelengths 249.5 nm and 238.5 nm λ max of ATV and RTV, respectively. Second method is based on area under curve(AUC) and the wavelength ranges selected for analysis were 254.5-244.5 nm for Atazanavir Sulfate and 243.5-233.5 nm for Ritonavir. Beer's law was obeyed in the concentration range of 10-50 μg/ml and 10-50 μg/ml for ATV and RTV, respectively. The methods were validated as per ICH guidelines. Statistical analysis proved that the methods were accurate, precise, and reproducible for analysis of ATV and RTV in tablets. The wide linearity range, sensitivity, accuracy and simple procedure imply that the proposed technique demonstrated to be appropriate for routine analysis and quality control assay of tablets.


Wankhede S.B.,Padmashree Dr D Y Patil Institute Of Pharmaceutical Science And Research | Mahajan A.M.,Padmashree Dr D Y Patil Institute Of Pharmaceutical Science And Research | Chitlange S.S.,Padmashree Dr D Y Patil Institute Of Pharmaceutical Science And Research
Der Pharma Chemica | Year: 2011

Two simple, sensitive, rapid spectrophotometric methods have been developed for simultaneous estimation of Gemifloxacin mesylate (GFX) and Ambroxol hydrochloride (AMB) in tablets. First method involves solving simultaneous equations based on measurement of absorbance at two wavelengths 272.0 nm and 249.5 nm λ max of GFX and AMB, respectively. Second method is first order derivative spectroscopy, wavelengths selected for quantitation were 216.0 nm for Gemifloxacin (zero cross for Ambroxol) and 279.0 nm for Ambroxol (zero cross for Gemifloxacin). Beer's law was obeyed in the concentration range of 8-40 μg/ml and 6-30 μg/ml for GFX and AMB, respectively. The methods were validated as per ICH guidelines. Statistical analysis proved that the methods were accurate, precise, and reproducible for analysis of GFX and AMB in tablets. The wide linearity range, sensitivity, accuracy and simple procedure imply that the proposed technique demonstrated to be appropriate for routine analysis and quality control assay of tablets.


Kulkarni P.A.,Padmashree Dr D Y Patil Institute Of Pharmaceutical Science And Research | Ganu G.P.,Padmashree Dr D Y Patil Institute Of Pharmaceutical Science And Research | Bhujbal S.S.,Padmashree Dr D Y Patil Institute Of Pharmaceutical Science And Research | Jadhav S.W.,Padmashree Dr D Y Patil Institute Of Pharmaceutical Science And Research | And 4 more authors.
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2010

Asthma is chronic inflammatory disorder of the airways characterized by acute exacerbation of coughing, dyspnoea, wheezing and chest tightness particularly at night as well as in the early morning. Asthma is also widely recognized as a disease of lung characterized by reversible bronchoconstriction, elevated basal airway tone and lymphocyte (Eosinophilis) activation and accumulation, epithelial cell dysfunction and damage, smooth muscle and submucosal gland hypertrophy, submucosal fibrosis, airway wall edema, mucus overproduction and episodes of non-specific airway hyper-responsiveness to spasmogens. For managing asthma attacks, symptomatic relief is foremost requirement. Bronchodilators and corticosteroids are used simultaneously for the effective treatment of acute and chronic asthma. In the present study, effect of combination of salbutamol (bronchodilator) and Prednisolone (corticosteroid) in different ratios (100:00, 70:30, 50:50, 30:70 and 00:100) was studied pre clinically to predict suitable ratio of both the drugs for the effective treatment of asthma. For evaluation, animal models used were Passive paw anaphylaxis in rats, Milk-induced eosinophilia in mice, isolated goat trachea, Broncho alveolar levage and Lung histopathology in mice. From this pre clinical studies it was found that, combination of Salbutamol (bronchodilator) and Prednisolone (corticosteroid) was effective for the treatment of acute and chronic asthma in all ratios but, at the same time the most effective ratio of drugs Salbutamol: Prednisolon was found to be70:30 which suggest that, corticosteroids at lower concentration are also equally effective so unnecessary use of high doses must be avoided. And as asthmatic attacks at early morning hrs are result of changes in circadian rhythm, this study warrants us to prepare chronopharmaceutical drug delivery system for the same combination of drugs and evaluate.

Loading Padmashree Dr D Y Patil Institute Of Pharmaceutical Science And Research collaborators
Loading Padmashree Dr D Y Patil Institute Of Pharmaceutical Science And Research collaborators