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Dongre P.R.,Padmashree Dr D Y Patil Institute Of Pharmaceutical Science And Research | Bhujbal S.S.,Padmashree Dr D Y Patil Institute Of Pharmaceutical Science And Research | Kumar D.,University Of Kashmir | Kumar D.,CSIR - Central Electrochemical Research Institute
Oriental Pharmacy and Experimental Medicine | Year: 2015

Curcuma longa, Zingiber officinale and Alpinia galanga are traditionally and scientifically reported for the treatment of respiratory disorders such as asthma, bronchial congestion and allergic reactions in respiratory tract. As part of a continuing effort aimed at the development of efficacious bronchodilator and anticataleptic herbal formulation for the treatment of asthma and related respiratory diseases. We have formulated herbal capsules (AHF) using Curcuma longa, Zingiber officinale and Alpinia galanga extracts. In this report, we have focused on the evaluation of AHF for bronchodilatory potential. AHF was studied on clonidine induced mast cell degranulation and OVA albumin induced airway inflammation model at the doses of 62.5,125 and 250 mg/kg. AHF at dose of 250 mg/kg showed significant protection of mast cell degranulation (40%) as compared to standard sodium cromoglycate (64%) while at doses of 62.5, 125, 250 mg/kg showed marked inhibition of total cells, eosinophils, neutrophils, lymphocytes, whereas in case of macrophages and monocytes an inhibition was observed at 125, 250 mg/kg along with the inhibition of IgE. The findings revealed that the bronchodilatory activity of AHF may be due to the mast cell stabilizing potential, suppression of IgE, and inhibition of release of inflammatory mediators. © 2015, Institute of Korean Medicine, Kyung Hee University and Springer Science+Business Media Dordrecht. Source


Ganu G.,Padmashree Dr D Y Patil Institute Of Pharmaceutical Science And Research | Garud A.,Padmashree Dr D Y Patil Institute Of Pharmaceutical Science And Research | Agarwal V.,Padmashree Dr D Y Patil Institute Of Pharmaceutical Science And Research | Suralkar U.,Padmashree Dr D Y Patil Institute Of Pharmaceutical Science And Research | And 2 more authors.
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2011

Mimusops elengi Linn (Sapotaceae) commonly known as Bakul, is a small to large evergreen tree. It is cultivated in gardens as an ornamental tree. Bark is used as a tonic, febrifuge, against odontopathy, inflammation. The part of plants was used in Thai traditional as rejuvenating and neuro tonic remedies, also Mimusops elengi is being screened for acetyl cholinesterase inhibitory activity. Despite the widespread uses of the plant, no scientific work is reported in literature regarding the effect of Mimusops elengi bark against anxiety like states therefore, the present study evaluates the anti-anxiety activity of methanolic, aqueous and n-butanol extract of bark of Mimusops elengi using elevated plus maze in swiss albino mice. Different doses of Test extract was evaluated in animals. Methanol extract at 50,100 and 200 mg/kg, aqueous extract at 100 and 200 while n-butanol extract at 200 mg/kg in mice were active but methanolic extract at 200 mg/kg was found to have more significant anxiolytic activity as compared to aqueous and n-butanol extract. Also activity of methanolic extract at 200 mg/kg was comparable with diazepam. Source


Nanda R.K.,Padmashree Dr D Y Patil Institute Of Pharmaceutical Science And Research | Kulkarni A.A.,Padmashree Dr D Y Patil Institute Of Pharmaceutical Science And Research | Yadav P.B.,Padmashree Dr D Y Patil Institute Of Pharmaceutical Science And Research
Der Pharma Chemica | Year: 2011

Two simple, sensitive, rapid spectrophotometric methods have been developed for simultaneous estimation of Atazanavir Sulfate (ATV) and Ritonavir (RTV) in tablets. First method involves solving simultaneous equations based on measurement of absorbance at two wavelengths 249.5 nm and 238.5 nm λ max of ATV and RTV, respectively. Second method is based on area under curve(AUC) and the wavelength ranges selected for analysis were 254.5-244.5 nm for Atazanavir Sulfate and 243.5-233.5 nm for Ritonavir. Beer's law was obeyed in the concentration range of 10-50 μg/ml and 10-50 μg/ml for ATV and RTV, respectively. The methods were validated as per ICH guidelines. Statistical analysis proved that the methods were accurate, precise, and reproducible for analysis of ATV and RTV in tablets. The wide linearity range, sensitivity, accuracy and simple procedure imply that the proposed technique demonstrated to be appropriate for routine analysis and quality control assay of tablets. Source


Wankhede S.B.,Padmashree Dr D Y Patil Institute Of Pharmaceutical Science And Research | Mahajan A.M.,Padmashree Dr D Y Patil Institute Of Pharmaceutical Science And Research | Chitlange S.S.,Padmashree Dr D Y Patil Institute Of Pharmaceutical Science And Research
Der Pharma Chemica | Year: 2011

Two simple, sensitive, rapid spectrophotometric methods have been developed for simultaneous estimation of Gemifloxacin mesylate (GFX) and Ambroxol hydrochloride (AMB) in tablets. First method involves solving simultaneous equations based on measurement of absorbance at two wavelengths 272.0 nm and 249.5 nm λ max of GFX and AMB, respectively. Second method is first order derivative spectroscopy, wavelengths selected for quantitation were 216.0 nm for Gemifloxacin (zero cross for Ambroxol) and 279.0 nm for Ambroxol (zero cross for Gemifloxacin). Beer's law was obeyed in the concentration range of 8-40 μg/ml and 6-30 μg/ml for GFX and AMB, respectively. The methods were validated as per ICH guidelines. Statistical analysis proved that the methods were accurate, precise, and reproducible for analysis of GFX and AMB in tablets. The wide linearity range, sensitivity, accuracy and simple procedure imply that the proposed technique demonstrated to be appropriate for routine analysis and quality control assay of tablets. Source


Vidyasagar N.,Padmashree Dr D Y Patil Institute Of Pharmaceutical Science And Research | Nanda R.,Padmashree Dr D Y Patil Institute Of Pharmaceutical Science And Research | Mangal R.,Padmashree Dr D Y Patil Institute Of Pharmaceutical Science And Research
Synthetic Communications | Year: 2012

Efficient syntheses of xanthenes have been described using a catalytic amount of perchloric acid in water. The high temperature and lengthy reaction time normally required for formation of xanthenes derivatives are not necessary when using a catalytic amount of perchloric acid. The method is relatively inexpensive, easily available, nonvolatile, nonexplosive, and thermally robust to catalyze the reaction at 80° C by simple heating with good to excellent yields. The advantages of the reaction involve simple reaction protocol, simple workup, and improved synthesis in the presence of perchloric acid as catalyst. © 2012 Taylor & Francis Group, LLC. Source

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