Paddrdypatil Institute Of Pharmaceutical Science And Research

Pimpri, India

Paddrdypatil Institute Of Pharmaceutical Science And Research

Pimpri, India
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Nanda R.K.,Paddrdypatil Institute Of Pharmaceutical Science And Research | Bhagwat V.V.,Paddrdypatil Institute Of Pharmaceutical Science And Research | Potawale S.E.,Paddrdypatil Institute Of Pharmaceutical Science And Research | Vidyasagar N.C.,Paddrdypatil Institute Of Pharmaceutical Science And Research | Mishra R.,Paddrdypatil Institute Of Pharmaceutical Science And Research
International Journal of ChemTech Research | Year: 2010

Three simple, accurate and reproducible spectrophotometric methods have been developed for the simultaneous estimation of Cefotaxime Sodium and Sulbactam Sodium in pharmaceutical dosage forms. The first method involves determination using the simultaneous equation method, the sampling wavelengths selected are 233.5 nm and 264 nm over the concentration ranges of 5-35 mcg ml -1 and 2.5-17.5 mcg ml -1 for Cefotaxime Sodium and Sulbactam Sodium respectively. The second method is the Area Under Curve method (AUC), the sampling wavelength ranges selected are 238.5-228.5nm and 269-259nm with linearity in the concentration ranges of 5-35 mcg ml -1 and 2.5-17.5 mcg ml -1 for Cefotaxime Sodium and Sulbactam Sodium respectively. The third method involves determination using the Multicomponent Mode Method, the sampling wavelengths selected are 233.5 nm and 264 nm over the concentration ranges of 5-35 mcg ml -1 and 2.5-17.5 mcg ml -1 for Cefotaxime Sodium and Sulbactam Sodium respectively. The results of the analysis were validated statistically and recovery studies were carried out as per ICH guidelines.

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