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Dnyanmote A.,Pad Dr Dy Patil Medical College And Hospital | Sinha N.,Pad Dr Dy Patil Medical College And Hospital | Chavan S.,Pad Dr Dy Patil Medical College And Hospital | Patel H.,Pad Dr Dy Patil Medical College And Hospital | And 2 more authors.
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2015

The breast lump is clinical presentation of numerous breast disorders ranging from innocent benign cysts to malignant neoplastic lesions. Distinction of benign from malignant is of paramount importance for patient care and proper management. One fourth of the women suffer from breast diseases in their lifetime. Carcinoma of the breast is the second most common cancer in the world. Lump in the breast is the commonest presentation of breast carcinoma. An early and accurate diagnosis is of paramount importance because the treatment can be initiated much earlier and may be life saving in most cases. The conventional open biopsy is considered as gold standard for confirming the diagnosis but it can be time consuming and economically unviable in most cases. A definite preoperative diagnosis of breast lump provides ample opportunity for patients to be counseled and single stage surgical treatment be made possible. Thus the combination of physical examination, mammography and FNAC came in the picture which is known as Triple Assessment. (Triple Test). A triple test has been formed which is quick, least invasive and cost effective in terms of money and time.

PubMed | Pad Dr Dy Patil Medical College And Hospital
Type: Journal Article | Journal: Indian journal of clinical biochemistry : IJCB | Year: 2012

Osteoporosis encompasses a wide spectrum of conditions associated with imbalance of osteoclastic and osteoblastic activities. The increased activity of osteoclasts leads to increased free radical formation and hence lipid peroxidation. Present study probes into the role of antioxidants as a palliative treatment for osteoporosis. It involved 50 healthy controls and 75 clinically diagnosed osteoporosis patients. Both the groups underwent baseline assessment of biochemical markers viz. osteoblastic markers: serum Alkaline phosphatase. Free or ionic calcium and Inorganic phosphorus, osteoclastic markers: serum Tartarate resistant acid phosphatase and Malondialdehyde and the antioxidant status: serum Superoxide dismutase and Erythrocyte reduced glutathione. The osteoporotic group was then divided into groups A (Vitamin E-Evinal 400 mg), B (Vitamin C-Celin 500 mg), C (Vitamin E+C-Evinal+Celin) for antioxidant supplementation for a period of 90 days. The results reveal that there is significant fall in concentration of serum MDA (p<0.001), TrACP (p<0.01). Improvement in antioxidant status is reflected by significant rise in concentration of serum SOD (p<0.001) and erythrocyte GSH (p<0.001) after 90 days of antioxidant supplementation in osteoporosis. The findings indicate that on the whole bone status improved with prolonged antioxidant vitamin supplementation, which can be used as a palliative treatment for osteoporosis. The efficacy is not affected whether the vitamins are administered singly or conjointly.

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