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Shinde S.N.,Pad Dr D Y Patil Medical College And Hospital | Dhadke V.N.,Dr V M Medical College | Suryakar A.N.,Government Medical College
Indian Journal of Clinical Biochemistry | Year: 2011

Increased oxidative stress is a widely accepted participant in the development and progression of diabetes and its complications. The present study has been undertaken to evaluate oxidative stress in type 2 diabetes mellitus and effect of vitamin E supplementation on oxidative stress. In all 120 subjects were enrolled in the present study, 40 subjects are age and sex matched controls. Test group comprised of clinically diagnosed (n = 80) type 2 diabetic patients. Biochemical parameters like serum MDA, nitric oxide, superoxide dismutase, erythrocyte reduced glutathione and platelet aggregation were analyzed in control and diabetic group. Test group is further categorized as Group I (n = 40) diabetics were treated by only hypoglycemic drugs and Group II (n = 40) diabetics were treated by hypoglycemic drugs with vitamin E supplementation. All above biochemical parameters were again reassessed after 3 months follow-up in both group and its values were compared with its respective baseline levels. The study shows, reduction of oxidative stress, improvement in antioxidant enzymes and endothelial dysfunction in group II, those were on treatment of hypoglycemic drugs along with vitamin E supplementation. Hence the present study may conclude that vitamin E supplementation along with hypoglycemic drugs may be beneficial to type 2 DM patients to minimize vascular complications. © 2010 Association of Clinical Biochemists of India. Source

Vij V.A.,Pad Dr D Y Patil Medical College And Hospital | Joshi A.S.,Seth G S Medical College and KEM Hospital
Journal of Clinical and Diagnostic Research | Year: 2013

context: Drinking lots of water is commonly suggested as a part of weight loss regimens. However, only few systematic studies have addressed this notion. In this study, the effect of drinking 1500 ml of water, over and above the daily water intake on body weight, body mass index (BMI) and body composition of overweight subjects was assessed. Aim: To evaluate the role of drinking excessive water in weight reduction and body fat reduction of overweight subjects. Settings and design: This study was conducted on 50 overweight girls for eight weeks, during which they were instructed to drink 500 ml of water, three times a day, half an hour before breakfast, lunch and dinner, which was over and above their daily water intake. Material and Methods: Body weight was measured in kilograms (kgs). BMI was calculated as weight in kilograms, which was divided by the square of height in metres. Body composition score was calculated as a sum of skin fold thickness in millimetres at three different sites, which was measured by using skin fold calipers. Pre and post-study body weight, body mass index and body composition scores were measured. Statistical Analysis: SPSS, version 14.0.1 and paired t-test were used to find out the statistical significance of the results. results: The mean values of the pre-study and post-study body weight, body mass index and body composition scores were 65.86 kg and 64.42 kg, 26.7002 and 26.1224 and 79.626 mm and 76.578 mm respectively. All the three results were highly significant statistically. conclusions: The decrease in body weight, body mass index and body composition scores of overweight subjects at the end of study period establishes the role of water induced thermogenesis in weight reduction of overweight subjects. Source

Jadhav S.,Pad Dr D Y Patil Medical College And Hospital | Gandham N.,Pad Dr D Y Patil Medical College And Hospital | Paul R.,Pad Dr D Y Patil Medical College And Hospital | Misra R.N.,Pad Dr D Y Patil Medical College And Hospital | And 3 more authors.
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2012

Septicaemia is a potentially life-threatening infection in which large number of bacteria are present in the blood. Septicaemia usually arises as a result of localized infection in the body. The primary site of infection may occur in the respiratory system, the skin, the gastrointestinal system or the genitourinary system. It may correspond with very debilitating infections such as meningitis. Bacteria usually spill over from the primary infection site into the blood and are carried throughout the body thereby causing infection in various systems of the body. It can be complicated by circulatory collapse, myocardial depression, increased metabolic rate and vasoregulatory perfusion abnormalities. Thus it must not be viewed as simply being an infection alone. A retrospective review was conducted during Jan. 2008 to Dec. 2011 at the Pad. Dr. D. Y. Patil Medical College and Hospital Pimpri Pune-18, India. 3180 blood samples were received from various wards, ICUs and OPDs. All blood samples were processed and identified by standard conventional methods. Antimicrobial susceptibility testing was done according to CLSI guidelines. A total of 1657(52.10%) were culture positive amongst which 894 (53.95%) were Gram Negative Bacteria (GNB) while 736 (44.41%) were Gram Positive Cocci(GPC) and 27 (1.62%) were Candida spp. Among all Gram negative bacteria, 28.97% were ESBL producers and 5.48% were MBL producers. 700(42.24%) isolates were from ICUs patients. Conclusion- Our finding provides information on spectrum of microorganisms and antibiotic resistance in septicaemic patients. Mortality and morbidity of neonatal sepsis is elevated and is considerably contributed by positive blood culture with preponderance of MDR GNB. Source

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