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Broadway, WA, United States

Schneider J.G.,Luxembourg Center for Systems Biomedicine | Schneider J.G.,Saarland University | Nadeau J.H.,Pacific Northwest Research Institute
Cell Metabolism | Year: 2015

Serotonin acts as neurotransmitter in the brain and as a multifaceted signaling molecule coordinating many physiological processes in the periphery. In a recent issue of Nature Medicine, Crane et al. (2014) find that peripheral serotonin controls thermogenesis in adipose tissue by modulating β-adrenergic stimulation of UCP-1, thereby affecting glucose homeostasis and weight gain. © 2015 Elsevier Inc.


Hakomori S.-I.,Pacific Northwest Research Institute | Hakomori S.-I.,University of Washington
FEBS Letters | Year: 2010

Glycosphingolipids (GSLs) GM3 (NeuAcα3Galβ4Glcβ1Cer) and GM2 (GalNAcβ4[NeuAcα3]Galβ4Glcβ1Cer) inhibit (i) cell growth through inhibition of tyrosine kinase associated with growth factor receptor (GFR), (ii) cell adhesion/motility through inhibition of integrin-dependent signaling via Src kinases, or (iii) both cell growth and motility by blocking " cross-talk" between integrins and GFRs. These inhibitory effects are enhanced when GM3 or GM2 are in complex with specific tetraspanins (TSPs) (CD9, CD81, CD82). Processes (i)-(iii) occur through specific organization of GSLs with key molecules (TSPs, caveolins, GFRs, integrins) in the glycosynaptic microdomain. Some of these processes are shared with epithelial-mesenchymal transition induced by TGFβ or under hypoxia, particularly that associated with cancer progression. © 2009 Federation of European Biochemical Societies.


Patent
Pacific Northwest Research Institute | Date: 2015-07-27

The invention is directed to compositions and methods for the detection of a malignant condition, and relates to the discovery of soluble and cell surface forms of HE4a polypeptides, including HE4a that is overexpressed in ovarian carcinomas. In particular the invention provides a nucleic acid sequence encoding HE4a, and also provides a method of screening for the presence of a malignant condition in a subject by detecting reactivity of an antibody specific for a HE4a polypeptide with a molecule naturally occurring in soluble and/or cell surface form in a sample from such a subject, and by hybridization screening using an HE4a nucleotide sequence, as well as other related advantages.


Grant
Agency: NSF | Branch: Standard Grant | Program: | Phase: | Award Amount: 299.74K | Year: 2013

A living system is distinguished from most of its non-living counterparts by the way it stores and transmits information. It is just this biological information that is the key to the biological functions. It is also at the heart of the conceptual basis of what we call systems biology. Much of the conceptual structure of systems biology can be built around the fundamental ideas concerning the storage transmission and use of biological information. Biological information resides, of course, in digital sequences in molecules like DNA and RNA, but also in 3-dimensional structures, chemical modifications, chemical activities, both of small molecules and enzymes, and in other components and properties of biological systems at many levels. The information depends critically on how each unit interacts with, and is related to, other components of the system. Biological information is therefore inherently context-dependent, which raises significant issues concerning its quantitative measure and representation. An important and immediate issue for the effective theoretical treatment of biological systems then is: how can context-dependent information be usefully represented and measured? This is important both to the understanding of the storage and flow of information that occurs in the functioning of biological systems and in evolution. This work involves both new ideas and the integration of new ideas. It represents new mathematical methods as well as a novel integration of approaches that are focused on the very real and practical problems of biological data analysis. The PI as developed a new conceptual approach that is novel and mathematically well-defined, exploring the relationships between graph properties and set complexity and considering new approaches to network analysis. New interaction distance measures are considered with a new way of dealing with especially large data sets, especially the maximal information coefficient, for which a general approach may be possible, certainly for a small number of variables, and possibly in the general case. The ideas will be tested on a number of diverse biological data sets, especially around gene expressions, and other variants. Current methods often fail in the face of truly complex dependencies in large data sets, and powerful new methods would be of high value. This work involves both new ideas and the integration of new ideas. It represents new mathematical methods as well as a novel integration of approaches that are focused on the very real and practical problems of biological data analysis.


Patent
Pacific Northwest Research Institute | Date: 2010-05-17

The invention is directed to compositions and methods for the detection of a malignant condition, and relates to the discovery of soluble forms of mesothelin polypeptides, including mesothelin related antigen (MRA). In particular the invention provides a nucleic acid sequence encoding MRA and an MRA variant. The invention also provides a method of screening for the presence of a malignant condition in a subject by detecting reactivity of an antibody specific for a mesothelin polypeptide with a molecule naturally occurring in soluble form in a sample from such a subject, and by hybridization screening using an MRA nucleotide sequence, as well as other related advantages.

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