Pachiyappas College

Chennai, India

Pachiyappas College

Chennai, India

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Maria Dorathi Anu M.,Pachiyappas College | Jayanthi M.,Pachiyappas College | Damodar Kumar S.,Pachiyappas College | Raja S.,Gandhi Institute of Technology and Management | Thirunavukkarasu S.V.,Dr Kamakshi Memorial Hospital
International Journal of ChemTech Research | Year: 2013

A new series of novel some substituted tetrazole derivatives (Compounds I-V) were synthesized by tetrazole react with different types of carbazone derivatives and various substituted type of benzaldehyde. The entire resulting compounds were characterized and confirmed by IR, 1H NMR, 13C NMR, mass and elemental analysis data. The antimicrobial activity of synthesized substituted tetrazole derivatives (compounds I-V) possess moderate specific activity (inhibition) against E-coli and are inactive against Staphylococcus aureus. Further, these compounds were screened for the anti-inflammatory activity by carrageenan induced paw oedema method in rats at a dose of 50 mg/kg body weight. The compounds (I-V) showed moderate enhancement of the activity. Among the tested compound, compound V [1,1-dimethyl-3-(phenyl (1H- tetrazol-1-yl) methyl amino urea] exhibited potential anti-inflammatory activity when compared to standard phenylbutazone (PBZ) at 5 mg/kg/po). From the above results, the relationship between the functional group variation and the biological activity of the evaluated compounds is discussed and the compound V was determined to be the most active.


Arumanayagam T.,Pachiyappas College | Murugakoothan P.,Pachiyappas College
Journal of Crystal Growth | Year: 2013

A new organic nonlinear optical single crystal guanidinium 4-nitrobenzoate (GuNB) was successfully grown by solution growth using the slow evaporation technique. Solubility and metastable zone width were determined for different solvents. The structure of the grown crystal has been determined by single crystal x-ray diffraction analysis. The presence of functional groups and coordination of para nitro benzoate ions in the GuNB crystal have been identified by FTIR and FT Raman spectroscopic studies. The optical transparency range has been studied through UV-vis-NIR spectroscopy. The second harmonic generation efficiency of the grown GuNB crystal has been obtained by the Kurtz-Perry powder technique. The laser induced surface damage threshold for the grown crystal has been measured using Nd: YAG laser. The mechanical behavior has also been studied by Vicker's microhardness test. © 2011 Elsevier B.V.

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