Pa Hertzen Moscow Research Institute Of Oncology

Moscow, Russia

Pa Hertzen Moscow Research Institute Of Oncology

Moscow, Russia
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Zaytsev K.I.,Moscow State Technical University | Gavdush A.A.,Moscow State Technical University | Karasik V.E.,Moscow State Technical University | Alekhnovich V.I.,Moscow State Technical University | And 4 more authors.
Journal of Applied Physics | Year: 2014

New experimental and theoretical results for the material parameter reconstruction using terahertz (THz) pulsed spectroscopy (TPS) are presented. The material parameter reconstruction algorithm was realized and experimentally implemented to study the test sample. In order to both verify the algorithm and to estimate the reconstruction accuracy, test sample material parameters obtained with the TPS were compared with the results of the same sample studying by the use of the backward-wave oscillator (BWO) spectroscopy. Thus, high reconstruction accuracy was demonstrated for the spectral range, corresponding to the BWO sensitivity and located between 0.2 and 1.2 THz. The numerical simulations were applied for determining the material parameter reconstruction stability in the presence of white Gaussian noise in TPS waveforms as well as fluctuations in the femtosecond (FS) optical pulse duration. We report a strong dependence of the inverse problem solution stability on these factors. We found that the instability of the FS optical pulse duration used for THz pulses generation and detection limits the material parameter reconstruction with TPS. © 2014 AIP Publishing LLC.


PubMed | Pa Hertzen Moscow Research Institute Of Oncology
Type: | Journal: Khirurgiia | Year: 2016

To investigate early and remote results of surgery in patients with recurrent non-small cell lung carcinoma (NSCLC) after previous chemoradiotherapy alone.The retrospective study included 14 NSCLC patients (10 men and 4 women, mean age 52.6 years) who were operated in thoracic department for the period June 2008 - December 2013. Histologically squamous cell carcinoma prevailed (64.3%). Prior to surgery stage IIB was diagnosed in 2 patients, IIIA in 11 and IIIB in 1 patient. The dose of radiotherapy ranged from 45 to 70 Gr (median 58Gr). The average number of chemotherapy cycles was 3.8 per patient. Pneumonectomy was performed in all patients except one who underwent left-sided lower lobectomy. In all cases bronchial stump was covered by vascularized muscle flap (intercostal, latissimus dorsi). Postoperative complications were classified by TMM system (Thoracic Morbidity and Mortality System).Postoperative complications were observed in 7 (50.0%) patients including level II in 2 cases, IIIA in 1 case, IVA in 3 patients and V (death) in 1 (7.1%) patient. Postoperative stages of lung cancer were IB in 2 cases, IIA in 1, IIB in 5, IIIA in 4 and IIIB in 2 patients. Overall 1, 2 and 3-year survival rate was 89.1%, 82.0% and 48.0% respectively (median 35.0 months). Recurrence-free survival was 84.2%, 72.0% and 24.8%, respectively (median 28.0 months). Overall and recurrence-free 5-year survival rate was 10.8%.Salvage surgery may be recommended as individual approach in patients with reccurent lung cancer after previous chemoradiotherapy.

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