General Childrens Hospital Panagiotis and Aglaia Kyriakou

Athens, Greece

General Childrens Hospital Panagiotis and Aglaia Kyriakou

Athens, Greece
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Grech I.,Technological Educational Institute of Athens | Kotsalas N.,General Hospital of Nikaia | Kyriakopoulos A.M.,Nasco AD Biotechnology Laboratory | Grech M.,General Childrens Hospital Panagiotis and Aglaia Kyriakou | And 3 more authors.
Epitheorese Klinikes Farmakologias kai Farmakokinetikes | Year: 2017

The antimicrobial resistance to newer agents tends to increase the weight of infectious disease morbidity and mortality. This has increased the interest for alternative approaches that enhance the natural defense of immune system. Innate immunity is a complex, evolutionary modified and multi-parameter line of defense against infectious agents that is physiologically triggered host cells. Innate immunity is of broad spectrum and can be further enhanced although when is hyper-functioning this may lead to over-inflammatory responses. As new approaches towards enhancement of innate immunity are promising, N-bromotaurine is recently described as paving new pathways towards the treatment of infectious diseases.


Grech I.,Technological Educational Institute of Athens | Kotsalas N.,General Hospital of Nikaia | Panagiotopoulos I.,251 General Hospital of Hellenic Air Force | Kyriakopoulos A.M.,Hellenic Society of Taurine | And 4 more authors.
Epitheorese Klinikes Farmakologias kai Farmakokinetikes | Year: 2017

Taurine (2-aminosoulphonic acid) is the most abundant free amino-acid in human organism and has an essential role in bile salts formation, the homeostatic maintenance, the osmotic regulation, and the stabilation of cellular membranes. In addition, the antiapoptotic effects and the anti-oxidant activities of taurine are essential for cyto-protection. Although these functional activities are not tissue specific, taurine reaches high concentrations when tissues are subjected to oxidation (inflammatory cells). Taurine is considered as having an essential role in inflammation and oxidative stress. At the site of inflammation, taurine reacts with hypochloric acid that is generated from myeloperoxidase of neutrophiles to form the N-chlorotaurine (NCT), and hypobromic acid to form the N-bromotaurine (NBrT). Both taurine derivatives have anti-microbial and anti-inflammatory properties. This summary focuses on recent research related to taurine and taurine derivative activities against inflammatory diseases, such as acne vulgaris, and therapeutic approaches by the use of NCT and NBrT. In addition, the anti-apoptotic effects and the anti-oxidant activities of taurine are essential for cytoprotection.

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