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Hidalgo-Tallon J.,University of Granada | Menendez-Cepero S.,Ozone Research Center | Vilchez J.S.,University of Granada | Rodriguez-Lopez C.M.,University of Granada | And 2 more authors.
Journal of Alternative and Complementary Medicine | Year: 2013

Objectives: The objectives of this study were to evaluate the effectiveness and tolerability of ozone therapy by rectal insufflation as add-on therapy in fibromyalgia management. Design: Patients with fibromyalgia received 24 sessions of ozone therapy during a 12-week period. At each session, the administered dose of ozone was 8 mg (200 mL of gas, at a concentration of 40 μg/mL). Ozone sessions were given 5 days a week during the first 2 weeks, twice a week from weeks 3-6, and weekly from weeks 7-12. Fibromyalgia Impact Questionnaire (FIQ) was the main outcome measure, and was administered at baseline and at weeks 4, 8, and 12. Secondary outcome measures, administered at baseline and at endpoint, were the Pittsburgh Sleep Quality Index, the Beck Depression Inventory, the State and Trait Anxiety Inventory, and the SF-12, the abbreviated form of the Short Form Health Survey. Emergent adverse reactions to treatment were recorded. Results: FIQ total scores decreased significantly during the study period, with the decrease being observed in the first 4 weeks of the study. Significant improvement was also seen both in depression scores and in the Physical Summary Score of the SF-12. Transient meteorism after ozone therapy sessions was the most frequently reported side-effect. Conclusions: At the dose and number of sessions used in this study, ozone therapy by rectal insufflation seems to be beneficial for physical symptoms and depression of fibromyalgia. © Copyright 2013, Mary Ann Liebert, Inc. 2013.


Diaz-SotoMari M.T.,University of Habana | Fraga Perez A.,University of Habana | Dranguet Vaillant J.,University of Habana | Mallok A.,University of Habana | And 3 more authors.
Ozone: Science and Engineering | Year: 2012

Ethanol withdrawal (EW) increases acetaldehyde accumulation and reactive oxygen species formation that promote damage to the brain. It is necessary to emphasize that while EtOH abuse and dependence are widespread, treatment options are extremely limited. This study aimed at investigating the protective effects of Ozone Oxidative Postconditioning (OzoneOxPost) on brain injury induced by oxidative stress and behavioral changes after 2 weeks of EW in rats. Four groups of rats (n = 10 each one) were settled: (I) Control, (II) Ethanol; (III) Ethanol + Ozone, and (IV) Ethanol + Oxygen. At the end of EW, rats were subjected to behavioral tests followed by brain tissue collection to measure markers of oxidative damage. OzoneOxPost increased food consumption, maintained water intake at the same levels as the control group, and reestablished cellular redox status. Anxiety, locomotor activity, and memory/learning of the rats were improved. These results demonstrated that OzoneOxPost protected the brain against oxidative injury, improving important functions of the Central Nervous Systems (CNS). It is a novel finding that is evidence of ozone's effects on CNS. © 2012 Copyright 2012 International Ozone Association.


Copello M.,Retinitis Pigmentosa National Reference Center Dr Salvador Allende Hospital | Menendez S.,Ozone Research Center | Hernandez F.,University of Habana
Ozone: Science and Engineering | Year: 2012

Retinitis pigmentosa is characterized by bad night vision, decrease of visual field and/or acuity. The aim of this article is to assess ozone therapy's efficacy in these patients, treated twice a year over 20 years. Forty patients received ozone via the rectal way, during 20 sessions as the only treatment, with repetition of this cycle every 6 months, and 16 received other medical treatments (control group). A significant decrease of the visual field in the control group in respect to the ozone group was observed after 20 years of treatment. In the ozone group, 50% of patients improved their visual field, accompanied with homeostasis in redox state. It is recommended to apply ozone therapy at 6-month intervals in order to maintain visual capabilities.The opinions and conclusions expressed in this article are those of the authors and contributors, and do not necessarily reflect those of the International Ozone Association, the editors, Editorial Board, or Taylor & Francis. Readers are to make their own decisions with regard to the work presented. These medical articles are enclosed, as in the past, as a service to the members of the IOA interested in medical applications. © 2012 Copyright 2012 International Ozone Association.


Fernandez O.S.L.,University of Habana | Pantoja M.,University of Habana | Soto M.T.D.,University of Habana | Dranguet J.,University of Habana | And 4 more authors.
Neurological Research | Year: 2012

Introduction/objectives: Although inflammation in disc hernia (DH) has been recognized and it is a wellknown process mediated by loss of the cellular redox balance, only a few studies about the impact of chronic oxidative stress on this neurological disorder have been made. Ozone therapy has been widely used with clinical efficacy in DH. This work aimed at characterizing the systemic redox status of patients with low back pain and neck pain as well as studying if ozone oxidative post-conditioning modified the pathological oxidative stress and protected against oxidative protein damage and if there is any relationship between oxidative changes and pain in both DH. Methods: Redox status of 33 patients with diagnosis of DH by computerized axial tomography, nuclear magnetic resonance, and clinical evaluations was studied. Ozone was administered by paravertebral way. After ozone treatment, plasmatic levels of antioxidant/pro-oxidant markers, pain, and life quality disability parameters were evaluated. Results: One hundred percent of patients showed a severe oxidative stress. Major changes in superoxide dismutase activity, total hydroperoxides, advanced oxidation protein products, fructolysine content, and malondialdehyde were observed. After ozone oxidative post-conditioning, there was a re-establishment of patients' cellular redox balance as well as a decrease in pain in both DH. A relationship between indicators of oxidative protein damage and pain was demonstrated. Conclusions: Ozone therapy protected against oxidation of proteins and reduced the pain. Relationship between markers of oxidative protein damage, disability parameters, and pain suggests the role of oxidative stress in the pathological processes involved in DH. © W. S. Maney & Son Ltd 2012.


Menendez S.,Ozone Research Center | del Cerro A.,Ozone Research Center | Alvarez T.,Ozone Research Center | Hernandez F.,Pharmacy and Food Institute
Reviews on Recent Clinical Trials | Year: 2012

The aim of this study was to evaluate the efficacy of ozone therapy in the treatment of 50 patients with peripheral vestibulocochlear syndrome. Ozone was injected in the cervical region C2-C3, for 20 sessions. Evaluation criteria was based in the evolution of nystagmus, tinnitus, hearing loss and vertigo. Also, oxidative stress parameters were measured. Results demonstrated that patient improvements, according to vertigo, hearing loss, tinnitus and nystagmus, were of 90, 80, 65 and 100 %, respectively. These patients were initially under condition of systemic oxidative stress, however, at the end of the study a redox balance was achieved. No side effects were observed. © 2012 Bentham Science Publishers.

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