Milton Keynes, United Kingdom
Milton Keynes, United Kingdom

Time filter

Source Type

Patent
Oxitec Ltd. | Date: 2017-04-05

The invention relates to the field of multiplex amplification. In particular, the invention relates to methods for assaying a sample for one or more nucleic acid targets in a single reaction based on the distinct melting temperatures or melting profiles of primers and/or probes. The invention also provides probes and kits for use in such methods.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-TP | Phase: KBBE.2013.1.2-04 | Award Amount: 8.53M | Year: 2014

The DROPSA consortium will create new knowledge and understanding of the damage and losses of fruit crops resulting from pests and pathogens, with a specific focus on the new and emerging threats due to Drosophila suzukii and quarantine pathogens Pseudomonas syringae, Xanthomonas fragariae and X. arboricola. The project will deliver a cost effective approach that can be widely implemented by the EU fruit industry. The aims and objectives are to: Determine the pathways of introduction and spread of D. suzukii and pathogens into the EU and develop preventative strategies and recommendations against the introduction of other dangerous fruit pests and pathogens. Determine the biology, ecology and interaction of these pests and diseases in different regions of Europe. This will involve a comprehensive evaluation of the life cycles, host ranges, capacities to disperse, the identification of natural enemies, plant-pathogen interactions as well as the semiochemicals involved in the behaviour of D. suzukii. The biology will provide the platform to develop practical solutions for sustainable pest control. Develop innovative and effective control options using approved chemicals, semiochemicals, novel antimicrobial compounds and biological control agents as well as cultural practices, sterile insect techniques and new mode of action compounds. The most reliable and effective control options will be combined to optimise an integrated pest management (IPM) strategy. Develop forecasting and decision support systems and risk mapping as a component of IPM. The economic viability of proposed strategies for fruit crop protection will be evaluated and used to support decision making in the implementation of IPM strategies to protect the EU fruit sector. To protect intellectual property (IP) and to undertake dissemination and exploitation actions to maximise the impact and up take of the recommended IPM by commercial fruit growers.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: SFS-03b-2014 | Award Amount: 4.09M | Year: 2015

More sustainable pest management methods are needed in order to reduce the negative effects of pesticides on human health and the environment. The overall goal of EUCLID is to contribute to secure the production of food for the increasing worldwide population while developing sustainable production approaches to be used in the European and Chinese agriculture. The choice of the crops of interest in EUCLID, i.e. fresh tomatoes, table and wine grapes, and leafy vegetables (lettuces, cabbages, etc.), is based on their economic importance for both European and Chinese fruit and vegetable production, but also for their exemplarity in representing different production systems (field \ greenhouse vegetables and ligneous perennial). This means that the solutions of the project could be used models for developing similar actions for other crops. The project is structured in 3 R&D work packages (WP), one WP dedicated to demonstration in field, one for dissemination and a WP devoted to project management. The project will exploit the thorough knowledge developed in the last years on IPM to adapt and optimize those tools and approaches which did not reach the field/market (yet). In addition, the consortium will work on the further development of high potential innovation pest management solutions. The consortium has been selected in order to integrate in the research process, from the very beginning, the main end-users of the projects results: farmers associations, SMEs, economists, experts in policy. The consortium also has a good coverage of both European and Chinese experts, in order to take advantage of the experience of each region and to more efficiently adapt the pest management solutions to the specific problems of European and Chinese farmers.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: SFS-03a-2014 | Award Amount: 7.00M | Year: 2015

Insects are the most diverse Class of life on earth, and different insects can be essential for, or highly damaging to, agriculture, horticulture and forestry. There is a pressing need, not just for new insecticides to combat resistance, but more specific, greener insecticides that target deleterious insects while sparing beneficial ones. This proposal aims to identify such insecticides by turning the insects own hormones against them, both by designing artificial neuropeptide mimetic analogs as candidate compounds, and by generating transgenic insects that carry deleterious neuropeptide payloads within them, that can propagate through a population and impact on survival at times of stress. We have assembled an international multi-actor consortium from EU member and associated member states, as well as a third country partner, with unparalleled experience in insect functional genomics, neuropeptide physiology, synthetic chemistry and synthetic biology, and in field-testing of candidates. Established links to agricultural, horticultural and forestry end-users, agencies/advisors and our SME partners ensure relevance to user need; and set out a pathway to exploitation and implementation of our results, for impact across three major economic sectors in the EU and globally. We will deliver novel, green neuropeptide-based insect pest biocontrol tools by: utilising beyond the State-of-the-Art technologies based on two approaches: rational design of neuropeptide hormone analogues; and development of genetically-encoded neuropeptides for translational insect synthetic biology in genetic pest management. bridging outstanding research and technology in neuroendocrinology and genetics to end user need, to ultimately produce neuropeptide hormone analogues and genetic pest management biocontrol tools. validating and demonstrating these novel insect biocontrol agents in laboratory, field and forest applications, based on user need and a market-driven approach.


Alphey L.,Oxitec Ltd | Alphey L.,University of Oxford
Annual Review of Entomology | Year: 2014

Genetics can potentially provide new, species-specific, environmentally friendly methods for mosquito control. Genetic control strategies aim either to suppress target populations or to introduce a harm-reducing novel trait. Different approaches differ considerably in their properties, especially between self-limiting strategies, where the modification has limited persistence, and self-sustaining strategies, which are intended to persist indefinitely in the target population and may invade other populations. Several methods with different molecular biology are under development and the first field trials have been completed successfully. © Copyright ©2014 by Annual Reviews. All rights reserved.


Patent
Oxitec Ltd | Date: 2016-09-21

Provided is an arthropod male germline gene expression system suitable for conditional expression of an effector gene in an Arthropod male germline. The system comprises a first expression unit comprising an effector gene and a promoter therefor operably linked thereto; and a second expression unit. Said second unit comprises a coding sequence for a transcription factor and an upstream regulatory element operably linked thereto, the transcription factor being capable of acting upon the promoter in the first expression unit to drive expression of the effector gene. The upstream regulatory element includes a promoter for the transcription factor; and a 5 UTR adjacent a start site for the transcription factor coding sequence. The upstream regulatory element driving sufficient expression of the transcription factor such that the transcription factor protein in turn drives transcription of the effector gene before meiosis. Also provided are uses of the system for instance in methods of biocontrol and quality control.


Patent
Oxitec Ltd | Date: 2016-03-14

The invention relates to the field of multiplex amplification. In particular, the invention relates to methods for assaying a sample for one or more nucleic acid targets in a single reaction based on the distinct melting temperatures or melting profiles of primers and/or probes. The invention also provides probes and kits for use in such methods.


Grant
Agency: GTR | Branch: Innovate UK | Program: | Phase: Collaborative Research & Development | Award Amount: 218.60K | Year: 2016

Dengue presents an immense public health challenge. Current technologies are failing to contain the geographical expansion of the mosquito vector (Aedes aegypti), resulting in a perilous spread of multiple dengue serotypes. This ground breaking project will underpin the wider implementation of a safe, sustainable, and environmentally compatible means of controlling this invasive species. Research targets include the effective eradication of Ae. aegypti from two rural hamlets where this mosquito is prevalent. Technical and operational objectives include the design and validation of critical equipment, and logistics and operational scaling. This innovative genetic technology has the potential to eliminate dengue on a continental level, resulting in universal social improvement and alleviation of the tremendous pressures being imposed upon health care systems. In the longer-term, uptake would lead to benefits such as reductions in pesticide use, significant employment, and control of the numerous other diseases transmitted by Ae. aegypti.


Patent
OXITEC Ltd | Date: 2016-01-11

The invention relates to the field of multiplex amplification. In particular, the invention relates to methods for assaying a sample for one or more nucleic acid targets in a single reaction based on the distinct melting temperatures or melting profiles of primers and/or probes. The invention also provides probes and kits for use in such methods.


A polynucleotide expression system is provided that is capable of alternative splicing of RNA transcripts of a polynucleotide sequence to be expressed in an organism.

Loading Oxitec Ltd collaborators
Loading Oxitec Ltd collaborators