Oxford BioMedica UK Ltd.

Oxford, United Kingdom

Oxford BioMedica UK Ltd.

Oxford, United Kingdom

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Patent
OXFORD BIOMEDICA UK Ltd | Date: 2015-09-14

A process for producing a retroviral or lentiviral vector formulation comprising a filter-sterilisation step wherein the filter-sterilisation step is not the final step in the purification process.


Patent
OXFORD BIOMEDICA UK Ltd | Date: 2015-09-14

A process for producing a retroviral or lentiviral vector formulation comprising a filter-sterilisation step wherein the filter-sterilisation step is not the final step in the purification process.


Patent
Oxford BioMedica UK Ltd | Date: 2017-07-19

A process for producing a retroviral or lentiviral vector formulation comprising a filter-sterilisation step wherein the filter-sterilisation step is not the final step in the purification process.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: HEALTH.2013.2.4.1-2 | Award Amount: 8.06M | Year: 2014

A successful vaccine against cancer is most likely to work through the induction of potent CD8\ T cells that can successfully kill tumour cells. But achieving this has proved difficult and only low level responses are induced by current vaccine approaches. Nonetheless, two therapeutic immunisation strategies have shown partial success in targeting prostate cancer, and one recently reached licensure. Recently, advances in infectious disease vaccinology have identified an exceptionally potent heterologous prime-boost immunisation strategy that has repeatedly induced T cell responses far greater than those observed in cancer immunotherapy. We will test this simian adenovirus MVA approach for the first time in cancer immunotherapy, targeting prostate tumours. We will use an MVA vector encoding the oncofetal antigen 5T4, that has been used safely already in over 500 patients. We will add a priming immunisation with a simian adenovirus aiming to enhance immunogenicity to therapeutic levels. We will use a new accelerated clinical trial design aiming to detect efficacy in relatively early stage prostate cancer patients, exploiting sensitive histological, biochemical and magnetic resonance imaging measures of vaccine efficacy. We will combine this with detailed immunomonitoring, and assess a new predictor of vaccine performance. In parallel, we will undertake detailed pre-clinical comparisons of 5T4 to other leading prostate cancer antigens, including five newly identified prostate-specific antigens, using a well-characterised murine prostate tumour model, exploiting new technologies for maximising CD8\ T cell induction with viral vectors. This SME-led collaboration of two universities with exceptional expertise in vaccinology and immunotherapy, two SMEs with expertise in viral vectored prime-boost immunisation and antigen discovery, and a global pharmaceutical company, will provide complementary abilities to accelerate development of this promising vaccine therapy.


Grant
Agency: GTR | Branch: Innovate UK | Program: | Phase: Collaborative Research & Development | Award Amount: 2.21M | Year: 2014

Parkinsons disease is caused by the degeneration of nerve cells in part of the brain; leading to the loss of dopamine, a chemical messenger which plays a vital role in coordinating body movement. In early stages of PD, oral levadopa (L-DOPA) medication is effective in managing the symptoms that include tremor, muscle stiffness and slow physical movement. However, the body progressively loses its ability to convert L-DOPA to dopamine thereby reducing its effectiveness and leading to the development of uncontrolled motor function. Oxford BioMedica has developed a once-only gene therapy approach to treat individuals with PD called OXB-102 that is administered once to the target region in the brain where it converts cells into a replacement dopamine factory. In essence, OXB-102 replaces a patient’s own lost source of the neurotransmitter analogous to the natural dopamine supply in the absence of PD.


Patent
OXFORD BIOMEDICA UK Ltd | Date: 2016-04-19

A method for determining a prognosis for benefit for a cancer patient receiving immunotherapy treatment involving (a) measuring a level of platelets and haemoglobin in a sample from the cancer patient, and (b) comparing the level of platelets in the sample to a reference level of platelets and comparing the level of haemoglobin in the sample to a reference level of haemoglobin, wherein a lower level of platelets and higher level of haemoglobin in the sample correlates with increased benefit to the patient.


Patent
OXFORD BIOMEDICA UK Ltd | Date: 2014-12-19

The present invention relates to a nucleic acid sequence comprising a binding site operably linked to a nucleotide of interest, wherein the binding site is capable of interacting with an RNA-binding protein such that translation of the nucleotide of interest is repressed in a viral vector production cell.


Patent
OXFORD BIOMEDICA UK Ltd | Date: 2015-08-05

A method for determining a prognosis for benefit for a cancer patient receiving immunotherapy treatment involving (a) measuring a level of haematocrit and haemoglobin in a sample from the cancer patient, and (b) comparing the level of haematocrit in the sample to a reference level of platelets and comparing the level of haemoglobin in the sample to a reference level of haemoglobin, wherein a lower level of haematocrit and higher level of haemoglobin in the sample correlates with increased benefit to the patient.


Patent
Oxford Biomedica UK Ltd | Date: 2016-10-05

A method for determining a prognosis for benefit for a cancer patient receiving immunotherapy treatment involving (a) measuring a level of platelets and haemoglobin in a sample from the cancer patient, and (b) comparing the level of platelets in the sample to a reference level of platelets and comparing the level of haemoglobin in the sample to a reference level of haemoglobin, wherein a lower level of platelets and higher level of haemoglobin in the sample correlates with increased benefit to the patient.


Grant
Agency: GTR | Branch: Innovate UK | Program: | Phase: Collaborative Research & Development | Award Amount: 1.79M | Year: 2013

Corneal transplantation is one of the most successful transplant procedures, due mainly to the relatively immune-privileged status of the eye and the fact that the cornea is largely free of blood vessels. However there is a failure rate in the first year of 14% and much higher in high rejection risk patients (such as those with failed previous grafts) due to blood vessel fromation in the patients eye, and the replacment of failed grafts is the indication for corneal transplantation for a significant proportion of patients in several referral centres. The prognosis in these patients can be so poor that many are not offered the opportunity of a further transplant and are left blind. EncorStat® is a novel engineered donor cornea, modified prior to transplantation, to extend rejection-free survival or prevent this risk entirely by suppressing blood vessel formation into the cornea post-transplant. We propose to use TSB funding to complete non-clinical safety studies and gain regulatory approval for clinical evaluation, to produce clinical grade vector and to use this to evaluate EncorStat® in a Phase I/IIa clinical trial.

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