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Franco C.,Wayne State University | Yoo W.,Translational Research and Clinical Epidemiology | Franco D.,Our Lady of the Assumption Catholic University
Bulletin of the NYU Hospital for Joint Diseases | Year: 2010

Lupus nephritis is one of the most serious manifestations of systemic lupus erythematosus (SLE). African Americans generally have a more severe presentation and more often progress to end stage renal disease (ESRD) than Caucasians. Several studies point to higher creatinine, low complement levels, thrombocytopenia, anemia, hypertension, and proliferative glomerulonephritis as predictors of ESRD in lupus nephritis within multi-ethnic cohorts. The purpose of the current study was to correlate clinical, serological, and immunological variables with the development of ESRD requiring dialysis in the African American population. Materials and Methods: A small retrospective study was performed with African American patients who had been diagnosed with lupus nephritis and biopsied between 1996 and 2006. Clinical, serological, and immunological variables were investigated. Chi square, t-test, ANOVA, and univariate and multivariable logistic regression models were applied to identify predictors of adverse outcome (ESRD requiring dialysis) in 67 patients with lupus nephritis. Subgroup analyses were performed in some cases to evaluate differences among the different classes. Results: Renal function was more depressed in the proliferative forms of lupus nephritis. Erythrocyte sedimentation rate (ESR) was increased mostly in classes III, IV, and V. Complement levels were uniformly decreased in the population studied. Nonetheless, C4 was more significantly depressed in the proliferative forms of lupus nephritis. We found that higher creatinine values (defined as creatinine greater than 1.2), low glomerular filtration rate (GFR) defined as GFR less than 60 mL/min/1.73 m2), class IV lupus nephritis, and hypertension are associated with ESRD in this population. On the other hand, class V lupus nephritis patients had significantly less risk to progress to ESRD (p values < 0.05). On subgroup analysis, neither low C3 nor low C4 levels were associated with ESRD requiring dialysis. Conclusion: As previously noted in other studies, hypertension, higher creatinine, proliferative nephritis, and decreased GFR are associated with ESRD requiring dialysis.


Cernuzzi L.,Our Lady of the Assumption Catholic University
IT Professional | Year: 2014

Praguay, with its population of approximately 6.8 million, has one of the lowest gross domestic products (GDP) per capita of Latin America. The central government has put IT on its policy agendas. The goal has been to introduce IT-based solutions to improve public administration processes; deliver quality public services; and improve transparency, citizen participation, and accountability. Academia is also supporting IT growth. Currently, 34 universities offer 46 computer science programs and a few professional-oriented master's programs in IT. There are also some promising research groups. However, in the absence of an effective national quality-control system, the quality of university programs varies. The o-government philosophy fosters a more horizontal and democratic way of governing, which benefits citizen participation, promotes transparency and strengthens technology with the aim of improving the quality of public services. The key components to any o-government initiative are transparency, participation and collaboration, and accountability.


Andrews P.,University of Sao Paulo | Pane J.,University of Trento | Pane J.,Our Lady of the Assumption Catholic University
Artificial Intelligence Review | Year: 2013

Folksonomies, often known as tagging systems, such as the ones used on the popular Delicious or Flickr websites, use a very simple Knowledge Organisation System. Users have thus been quick to adopt this system and create extensive annotations on the Web. However, because of the simplicity of the folksonomy model, the semantics of the tags used is not explicit and can only be inferred from their context of use. This is a barrier for the automatic use of such Knowledge Organisation Systems by computers and new techniques have been developed to extract the semantic of the tags. In this article we discuss the drawbacks of some of these approaches and propose a generalization of the different approaches to detect new senses of terms in a folksonomy. Another weak point of the current state of the art in the field is the lack of formal evaluation methodology; we thus propose a novel evaluation framework. We introduce a dataset and evaluation methodology that enable the comparison of results between different approaches to sense induction in folksonomies. Finally we discuss the performances of different approaches to the task of homonymous/polysemous tag detection and synonymous identification. © 2012 Springer Science+Business Media Dordrecht.


Cernuzzi L.,Our Lady of the Assumption Catholic University | Molesini A.,University of Bologna | Omicini A.,University of Bologna | Zambonelli F.,University of Modena and Reggio Emilia
International Journal of Software Engineering and Knowledge Engineering | Year: 2011

Changes and adaptations are always necessary after the deployment of a multi-agent system (MAS), as well as of any other type of software systems. Some of these changes may be simply perfective and have local impact only. However, adaptive changes to meet new situations in the operational environment of the MAS may impact globally on the overall design. More specifically, those changes usually affect the organizational structure of the MAS. In this paper we analyze the issue of design change/adaptation in a MAS organization, and the specific problem of how to properly model/design a MAS so as to make it ready for adaptation. Special attention is paid to the Gaia methodology, whose suitability in dealing with adaptable MAS organizations is also discussed with the help of an illustrative application example. © 2011 World Scientific Publishing Company.


Guevara J.,Our Lady of the Assumption Catholic University | Fatecha A.,Our Lady of the Assumption Catholic University | Vargas E.,Our Lady of the Assumption Catholic University | Barrero F.,Polytechnic University of Valencia
Conference Record - IEEE Instrumentation and Measurement Technology Conference | Year: 2014

Ubiquitous and plug-And-play are fundamental characteristics in the development of Wireless Sensor Networks (WSNs). The ISO/IEC/IEEE 21451 standard has proven its interest in this development, making easier the introduction of both characteristics in the design of wireless sensor nodes. Re-configurability is a new subject that is gaining importance in the development of embedded systems and wireless sensor nodes in the last few years. Sensors re-configurability capability increases the scalability and heterogeneity abilities of sensor nodes. However, previous developed frameworks and standards do not support the implementation of these capabilities into novel wireless sensor nodes. This paper presents an ISO/IEC/IEEE 21451 based node architecture for WSN nodes that support the management of reconfigurable devices. The node is implemented in an Environmental Sensor Network to validate its interest and utility. © 2014 IEEE.


Hume A.,University of Trento | Giunchiglia F.,University of Trento | Cemuzzi L.,Our Lady of the Assumption Catholic University
Proceedings - 2015 41st Latin American Computing Conference, CLEI 2015 | Year: 2015

The digital content of users is commonly organised in local directories representing entities from the real world (e.g., people, locations, organisations, and events). Different representations can show different "versions", using different names to refer to the same real world entity (e.g., George Lombardi, Lombardi G., Dr. Lombardi). Although the data in these directories are related and can even complement each other, there are no formal links connecting them and allowing users to share and search across them. In this work we propose a Distributed Directory System, applied to A Healthcare Use Case for Rural Areas that allows peers: (i) to maintain full control over their data; and (ii) to find different versions of an entity based on any name that is used in the network to refer to it. We evaluate the approach in networks of different sizes using PlanetLab and we show promising results in terms of scalability. © 2015 IEEE.


Chenu-Abente R.,University of Trento | Giunchiglia F.,University of Trento | Cernuzzi L.,Our Lady of the Assumption Catholic University
Proceedings - 2015 41st Latin American Computing Conference, CLEI 2015 | Year: 2015

Computer-enabled social services like tagging or sharing are ubiquitous in current web applications that are aimed to a group of users. These services do not only add value and new functionalities to their applications but also create a network of users and services that interconnect them to a wider on-line ecosystem. Currently these social networks mainly use the vast amount of user-created content, and activity logs to apply to provide recommendations and more complex services. This paper presents the Social Core a social network engine that implements semantic-based functionalities like semantic annotations, semantic search semantic-enhanced access control and user privacy protection. The Social Core was integrated as part of the SmartCampus mobile platform, which was tested by around one hundred students, and it is currently being further developed as part of European FP7 project SmartSociety. © 2015 IEEE.


Corvalan J.,Our Lady of the Assumption Catholic University
ARQ | Year: 2010

The reuse of materials acts as the generator of this home remodel in a traditional zone of Asuncion. The interior walls or masonry and concrete are saved and pallets are used to generate a vault that unites the parts.


Torres M.,Our Lady of the Assumption Catholic University | Baran B.,Our Lady of the Assumption Catholic University
Proceedings - 2015 41st Latin American Computing Conference, CLEI 2015 | Year: 2015

The difficulty to solve problems with many, possibly conflicting, objectives logically increases with the number of objectives, what makes them difficult to solve using multi-objective algorithms like the well known NSGA-II. Therefore, this work proposes the use of a particle swarm optimization (PSO) algorithm to solve many-objective problems. The main premise of this work is that MOPSO may be a good option for solving many-objective problems, presenting experimental evidence that supports this premise using the well known DTLZ benchmark with different performance metrics such as hypervolume, coverage and generational distance, among others. © 2015 IEEE.


Cernuzzi L.,Our Lady of the Assumption Catholic University | Zambonelli F.,University of Modena and Reggio Emilia
Knowledge Engineering Review | Year: 2011

We analyze the problem of modeling and developing multiagent systems (MASs) from the organizational theory point of view. In particular, we focus on the critical issue of adapting MASs organizations whenever changes in the structure of the MAS are required. We survey different relevant agent-oriented methodologies and discuss their suitability in dealing with adaptation in multiagent organizations. Finally, we present some critical considerations about the analyzed methodologies together with some open issues related to the process of modeling organizations for facilitating their adaptations. © 2011 Cambridge University Press.

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