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Kallio M.A.,University of Oulu | Kovala T.T.,Deaconess Institute of Oulu | Niemela E.N.K.,Raahe District Hospital | Huuskonen U.E.J.,University of Oulu | Tolonen E.U.,University of Oulu
Journal of Clinical Neurophysiology | Year: 2011

The finding of isolated teres minor denervation during examination of the shoulders using MRI occurs in 3% to 5.5% of examinations. We describe eight patients with shoulder pain, in whom electromyography revealed an isolated lesion in the motor branch of the axillary nerve to the teres minor muscle. This nerve lesion is clinically impossible to diagnose, the lack of a clear diagnosis often resulting in inappropriate treatment and therefore potentially prolonged disability. Hence, when encountering shoulder problems, neurophysiologists should examine the teres minor muscle as a matter of routine. In the MRI and ultrasound examinations of patients with shoulder problems, therefore, not only routine tendon and joint structure but also muscles should be evaluated. Copyright © 2011 by the American Clinical Neurophysiology Society.


Hakala M.,University of Tampere | Kroger H.,Kuopio University Hospital | Valleala H.,University of Helsinki | Hienonen-Kempas T.,Hoffmann-La Roche | And 5 more authors.
Scandinavian Journal of Rheumatology | Year: 2012

Objectives: To study the efficacy and safety of once-monthly oral ibandronate in the prevention of glucocorticoid (GC)-induced osteoporosis (GIOP) in postmenopausal women with inflammatory rheumatic diseases. Method: A randomized, double-blind, placebo-controlled, parallel-group study of 140 postmenopausal women was conducted. At baseline, the mean lumbar spine (LS) (L1-L4) bone mineral density (BMD) was normal or osteopaenic (T-score ≤ -2.0) and the patients were receiving treatment with 5-15 mg/day of prednisone equivalent. Patients were randomized 1:1 to receive either monthly oral ibandronate 150 mg or placebo for 12months. All patients received vitamin D and calcium supplements. The primary endpoint was the relative change in mean LS BMD from baseline to 12 months. Results: Mean LS BMD increased significantly by 2.6% and 3.2% from baseline to 6 and 12 months with ibandronate compared to 0.3% and -0.1% with placebo, respectively (p < 0.001). Comparable significant mean increases were also found in trochanter, femoral neck and total hip BMDs at 12 months. Reductions in the serum levels of bone turnover markers C-terminal telopeptide of type I collagen (sCTX), N-terminal propeptide of type I procollagen (P1NP), and tartrate-resistant acid phosphatase (TRACP) were significantly more marked in the ibandronate group than in the placebo group at 1, 6, and 12 months. Adverse events (AEs) were reported at a similar frequency in both groups. A higher proportion of serious AEs (SAEs) were reported in the ibandronate group without emergence of any single SAE. Conclusions: Once-monthly oral ibandronate provides a significant increase in LS and total hip BMD with an acceptable safety profile in postmenopausal women treated with low-dose GCs for inflammatory rheumatic diseases. © 2012 Taylor & Francis on license from Scandinavian Rheumatology Research Foundation.


Niu K.,Tohoku University | Ahola R.,University of Oulu | Guo H.,Tohoku University | Korpelainen R.,University of Oulu | And 13 more authors.
Journal of Bone and Mineral Metabolism | Year: 2010

Although there is ample evidence supporting the effectiveness of physical activity in the prevention and treatment of osteoporosis, there are no previous studies to examine the effect of office-based brief high-impact exercise (HIE) on bone mineral density (BMD) in healthy premenopausal women. This study evaluated the effects of office-based HIE on BMD in healthy premenopausal Japanese women. Ninety-one healthy premenopausal women were randomized to receive stretching exercise (SE) or HIE (stretching, along with up to 5 × 10 vertical and versatile jumps) for 12 months. The BMD of the lumbar spine and proximal femur was measured using dual-energy X-ray absorptiometry. Several cardiovascular risk factors and leg strength also were assessed. An accelerometer-based recorder was used to measure daily impact loading in four 1-week samples. The progression of the HIE program was ensured by the accelerometer. Thirty-three women (71.7%) in the SE group and 34 (75.6%) in the HIE group completed the study. There was a significant difference in the change in the femoral neck BMD between the groups in favor of the HIE group [0.6% (95% CI: -0.4, 1.7) vs. -1.0% (95% CI: -2.2, 0.2)]. Adiponectin, LDL, HDL, and the leg strength of participants in both the groups improved during the intervention. These finding suggested that office-based brief HIE can be recommended for premenopausal women for preventing bone mineral loss. © 2010 The Japanese Society for Bone and Mineral Research and Springer.


Karppanen A.-K.,University of Oulu | Ahonen S.-M.,University of Oulu | Tammelin T.,Research Center for Sport and Health science | Vanhala M.,University of Oulu | And 3 more authors.
International Journal of Circumpolar Health | Year: 2012

Objectives: To compare the physical fitness and physical activity of 8-year-old overweight children (n=53) to normal weight children (n=65), and to determine whether a significant relationship exists between physical activity of parents and their children. Study design: A cross-sectional study. Methods: A total of 119 children from Northern Finland were recruited for the study. Waist circumference, height, weight and BMI were measured. Physical activity of the children and their parents was determined with self-administered 7-day recall questionnaires (PAQ-C). Physical fitness of the children was evaluated with 7 items of the EUROFIT-test battery (flamingo balance test, plate tapping, sit-and-reach test, sit-ups, bent arm hang and 10×5 shuttle run). Aerobic capacity of the children was tested with 6-minute walking test. Results: Overweigh was related to impaired performance in tests requiring muscle endurance, balance, explosive power of lower extremities, upper body strength and endurance, speed and agility in both genders and aerobic capacity in boys. Physical activity levels of overweight boys (2.41 SD 0.72) were lower than their lean counterparts (2.91 SD 0.64, p=0.004); no such difference was observed in girls (2.53 SD 0.64 vs. 2.59 SD 0.68, p=0.741). Physical activity was significantly associated with better performance in several physical fitness tests in boys, but not in girls. Mothers' physical activity was associated with children's physical activity (r=0.363, p<0.001), but no such association was found between fathers and children (r=0.019, p=0.864). Conclusion: This study shows an inverse relationship between excess bodyweight and physical fitness in children. Mother-child relationship of physical activity appeared to be stronger than father-child relationship. Improving physical fitness in children through physical activity might require interventions that are responsive to the ability and needs of overweight children and their families and focus on helping parents and children to be physically active together. © 2012 Anna-Kaisa Karppanen et al.


Riso E.-M.,University of Tartu | Ahtikoski A.M.,University of Oulu | Takala T.E.S.,Deaconess Institute of Oulu | Seene T.,University of Tartu
Biology of Sport | Year: 2010

During three weeks of hindlimb suspension muscle mass decreased 36% (p<0.05) in Soleus (Sol) muscle, 17% (p<0.05) in Gastrocnemius (GM) and had tendences to decrease in plantaris (Pia) (15%) and in extensor digitorum longus (EDL) (8%) muscles. Hindlimb grip strength decreased gradually during three weeks of unloading. Specific mRNA level for type I collagen decreased during three weeks of unloading in Sol muscle by 28% (p<0.05) and in GM muscle by 34% (p<0.05). mRNA level for type III collagen decreased in Sol by 22% (p<0.05) and in GM by 51% (p<0.001). Non-fibrillar type IV collagen mRNA level decreased in both above-described muscles about 25% (p<0.05). Lysyl oxidase (LO) mRNA level decreased by 46% (p<0.05) during three weeks of unloading only in Sol muscle. Matrix metalloproteinase-2 (MMP-2) mRNA level increased during reloading period in Sol and GM muscles subsequently 28% (p<0.05) and 49% (p<0.001). During unloading the activity of tissue inhibitors of metalloproteinases (TIMP-1 and TIMP-2) in slow-twitch (ST) and fast-twitch (FT) muscles changed in different directions: during first week of suspension, their expression decreased in Sol muscle by 31% (p<0.05) and increased in Pla and GM muscle subsequently by 24% (p<0.05) and 31% (p<0.001). The pretranslational level of changes in fibrillar and non-fibrillar collagen, MMP-2, LO, TIMP-1 and TIMP-2 -are shown for first time together with changes in muscle strength and motor activity during unloading and reloading.


Vanhala M.L.,Deaconess Institute of Oulu | Vanhala M.L.,University of Oulu | Laitinen J.,Finnish Institute of Occupational Health | Kaikkonen K.,Deaconess Institute of Oulu | And 3 more authors.
Journal of Human Nutrition and Dietetics | Year: 2011

Information on the role of family dietary behaviours is needed to enable the design of effective interventions for treatment of childhood obesity. The present study aimed to analyse differences in consumption and predictors of fruit, berries and vegetables (FBV) between normal-weight and overweight treatment-seeking children and their parents.Methods: Fifty-four treatment-seeking overweight and 65 normal-weight 8-year-old children and their parents participated in the present study. Children's and parent's consumption of FBV were assessed by a food frequency questionnaire. Availability of vegetables at home meals, child's preference for FBV and parent's control over portion size were determined. Weight and height were measured and the standardised body mass index of each child was calculated. Multiple linear regression analysis was performed to investigate the predictors of children's FBV consumption.Results: Normal-weight children and parents ate FBV more frequently than overweight children. In the multiple linear regression analysis, mother's (β = 0.476, P ≤ 0.001) and father's consumption of FBV (β = 0.347, P = 0.001) and child's preference for eating vegetables (β = 0.259, P = 0.002) were positively associated with the child's consumption of FBV. In overweight children, parent's consumption of FBV was the only predictor of the offspring's consumption of FBV (P = 0.002).Conclusions: Predictors related to FBV consumption appear to be the similar in normal-weight and treatment-seeking overweight children. The findings obtained in the present study highlight the importance of parental modelling in determining the consumption of FBV in their children. © 2010 The Authors. Journal compilation © 2010 The British Dietetic Association Ltd.


Vanhala M.L.,Deaconess Institute of Oulu | Vanhala M.L.,University of Oulu | Keinanen-Kiukaanniemi S.M.,University of Oulu | Kaikkonen K.M.,Deaconess Institute of Oulu | And 4 more authors.
BMC Public Health | Year: 2011

Background: Very few studies have evaluated the association between a child's lifestyle factors and their parent's ability to recognise the overweight status of their offspring. The aim of this study was to analyze the factors associated with a parent's ability to recognise their own offspring's overweight status. Methods. 125 overweight children out of all 1,278 school beginners in Northern Finland were enrolled. Weight and height were measured in health care clinics. Overweight status was defined by BMI according to internationally accepted criteria. A questionnaire to be filled in by parents was delivered by the school nurses. The parents were asked to evaluate their offspring's weight status. The child's eating habits and physical activity patterns were also enquired about. Factor groups of food and physical activity habits were formed by factor analysis. Binary logistic regression was performed using all variables associated with recognition of overweight status in univariate analyses. The significant risk factors in the final model are reported using odds ratios (ORs) and their 95% confidence intervals (CIs). Results: Fifty-seven percent (69/120) of the parents of the overweight children considered their child as normal weight. Child's BMI was positively associated with parental recognition of overweight (OR 3.59, CI 1.8 to 7.0). Overweight boys were less likely to be recognised than overweight girls (OR 0.14, CI 0.033 to 0.58). Child's healthy diet (OR 0.22, CI 0.091 to 0.54) and high physical activity (OR 0.29, CI 0.11 to 0.79) were inversely related to parental recognition of overweight status. Conclusions: Child's healthy eating habits and physical activity are inversely related to parental recognition of their offspring's overweight. These should be taken into account when planning prevention and treatment strategies for childhood obesity. © 2011 Vanhala et al; licensee BioMed Central Ltd.


Ahola R.,University of Oulu | Korpelainen R.,University of Oulu | Korpelainen R.,Deaconess Institute of Oulu | Vainionpaa A.,University of Oulu | And 2 more authors.
Journal of Biomechanics | Year: 2010

Mechanical loading increases and maintains bone mass and strength. Daily stress stimulus and osteogenic index theories have been suggested to describe the osteogenic potential of exercise, using exponential or logarithmic relationships, respectively, between loading numbers and magnitude. Inspired by these theories, the aim of this study was to develop and test a daily impact score (DIS) using long-term continuous acceleration measurements of exercise. Acceleration data were collected during a previous exercise trial, in which the subjects (healthy women, 35-40 years, N=34 in the high-impact exercise group and N=30 in the control group) wore a body movement monitor on their waist during the 12-month study. DIS was calculated from the 12-month average daily acceleration distributions in two ways: DISExp adopted from the daily stress stimulus and DISLog simplified from the osteogenic index. Areal bone mineral density (aBMD) at the proximal femur and cortical bone geometry at the mid-femur were measured at baseline and 12 months. DIS calculated in either of the ways was significantly higher in the exercise group than in the control group. DISExp and DISLog were strongly correlated (R=0.982). Both DISExp and DISLog were significantly associated with 12-month aBMD changes at the hip (R up to 0.550, p<0.01) and geometry changes at the mid-femur (R up to 0.472, p<0.05) in the exercise group. DIS calculated either from exponential or logarithmic relationship can be used in acceleration-based measurements of daily exercise. DIS was positively related with changes in hip aBMD and mid-femur bone geometry after 12 months of exercise. © 2010 Elsevier Ltd.


Isojarvi H.,University of Oulu | Keinanen-Kiukaanniemi S.,University of Oulu | Kallio M.,University of Oulu | Kaikkonen K.,Deaconess Institute of Oulu | And 4 more authors.
Medicine and Science in Sports and Exercise | Year: 2010

Purpose: This study examined the association between physical activity and fitness and peripheral nervous system (PNS) function in overweight and obese individuals. Methods: Forty nondiabetic overweight adults (mean ± SD; age = 44 ± 11 yr) were recruited for the study. Peroneal motor nerve and radial, sural, and medial plantar sensory nerve conductions were studied. Maximal oxygen uptake was measured in an incremental bicycle ergometer test. Physical activity was assessed by accelerometer and self-reporting. We analyzed the data using multiple stepwise linear regression models adjusted for age, height, and skin temperature. Results: V̇O2max predicted 17% of peroneal distal compound muscle action potential (CMAP) amplitude variation and 16% of peroneal proximal CMAP amplitude variation. Physical activity index at the age of 30 yr predicted 9% of peroneal motor nerve conduction velocity (NCV), 8% of peroneal F-wave maximum latency, 14% of medial plantar sensory latency, and 10% of medial plantar sensory NCV variation. CONCLUSIONS: Physical activity and fitness are positively associated with PNS function and should be encouraged in overweight people. Copyright © 2010 by the American College of Sports Medicine.


PubMed | Deaconess Institute of Oulu
Type: | Journal: BMC public health | Year: 2011

Very few studies have evaluated the association between a childs lifestyle factors and their parents ability to recognise the overweight status of their offspring. The aim of this study was to analyze the factors associated with a parents ability to recognise their own offsprings overweight status.125 overweight children out of all 1,278 school beginners in Northern Finland were enrolled.Weight and height were measured in health care clinics. Overweight status was defined by BMI according to internationally accepted criteria. A questionnaire to be filled in by parents was delivered by the school nurses. The parents were asked to evaluate their offsprings weight status. The childs eating habits and physical activity patterns were also enquired about. Factor groups of food and physical activity habits were formed by factor analysis. Binary logistic regression was performed using all variables associated with recognition of overweight status in univariate analyses. The significant risk factors in the final model are reported using odds ratios (ORs) and their 95% confidence intervals (CIs).Fifty-seven percent (69/120) of the parents of the overweight children considered their child as normal weight. Childs BMI was positively associated with parental recognition of overweight (OR 3.59, CI 1.8 to 7.0). Overweight boys were less likely to be recognised than overweight girls (OR 0.14, CI 0.033 to 0.58). Childs healthy diet (OR 0.22, CI 0.091 to 0.54) and high physical activity (OR 0.29, CI 0.11 to 0.79) were inversely related to parental recognition of overweight status.Childs healthy eating habits and physical activity are inversely related to parental recognition of their offsprings overweight. These should be taken into account when planning prevention and treatment strategies for childhood obesity.

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