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Riso E.-M.,University of Tartu | Ahtikoski A.M.,University of Oulu | Takala T.E.S.,Deaconess Institute of Oulu | Seene T.,University of Tartu
Biology of Sport | Year: 2010

During three weeks of hindlimb suspension muscle mass decreased 36% (p<0.05) in Soleus (Sol) muscle, 17% (p<0.05) in Gastrocnemius (GM) and had tendences to decrease in plantaris (Pia) (15%) and in extensor digitorum longus (EDL) (8%) muscles. Hindlimb grip strength decreased gradually during three weeks of unloading. Specific mRNA level for type I collagen decreased during three weeks of unloading in Sol muscle by 28% (p<0.05) and in GM muscle by 34% (p<0.05). mRNA level for type III collagen decreased in Sol by 22% (p<0.05) and in GM by 51% (p<0.001). Non-fibrillar type IV collagen mRNA level decreased in both above-described muscles about 25% (p<0.05). Lysyl oxidase (LO) mRNA level decreased by 46% (p<0.05) during three weeks of unloading only in Sol muscle. Matrix metalloproteinase-2 (MMP-2) mRNA level increased during reloading period in Sol and GM muscles subsequently 28% (p<0.05) and 49% (p<0.001). During unloading the activity of tissue inhibitors of metalloproteinases (TIMP-1 and TIMP-2) in slow-twitch (ST) and fast-twitch (FT) muscles changed in different directions: during first week of suspension, their expression decreased in Sol muscle by 31% (p<0.05) and increased in Pla and GM muscle subsequently by 24% (p<0.05) and 31% (p<0.001). The pretranslational level of changes in fibrillar and non-fibrillar collagen, MMP-2, LO, TIMP-1 and TIMP-2 -are shown for first time together with changes in muscle strength and motor activity during unloading and reloading.

Hakala M.,University of Tampere | Kroger H.,Kuopio University Hospital | Valleala H.,University of Helsinki | Hienonen-Kempas T.,Roche Holding AG | And 5 more authors.
Scandinavian Journal of Rheumatology | Year: 2012

Objectives: To study the efficacy and safety of once-monthly oral ibandronate in the prevention of glucocorticoid (GC)-induced osteoporosis (GIOP) in postmenopausal women with inflammatory rheumatic diseases. Method: A randomized, double-blind, placebo-controlled, parallel-group study of 140 postmenopausal women was conducted. At baseline, the mean lumbar spine (LS) (L1-L4) bone mineral density (BMD) was normal or osteopaenic (T-score ≤ -2.0) and the patients were receiving treatment with 5-15 mg/day of prednisone equivalent. Patients were randomized 1:1 to receive either monthly oral ibandronate 150 mg or placebo for 12months. All patients received vitamin D and calcium supplements. The primary endpoint was the relative change in mean LS BMD from baseline to 12 months. Results: Mean LS BMD increased significantly by 2.6% and 3.2% from baseline to 6 and 12 months with ibandronate compared to 0.3% and -0.1% with placebo, respectively (p < 0.001). Comparable significant mean increases were also found in trochanter, femoral neck and total hip BMDs at 12 months. Reductions in the serum levels of bone turnover markers C-terminal telopeptide of type I collagen (sCTX), N-terminal propeptide of type I procollagen (P1NP), and tartrate-resistant acid phosphatase (TRACP) were significantly more marked in the ibandronate group than in the placebo group at 1, 6, and 12 months. Adverse events (AEs) were reported at a similar frequency in both groups. A higher proportion of serious AEs (SAEs) were reported in the ibandronate group without emergence of any single SAE. Conclusions: Once-monthly oral ibandronate provides a significant increase in LS and total hip BMD with an acceptable safety profile in postmenopausal women treated with low-dose GCs for inflammatory rheumatic diseases. © 2012 Taylor & Francis on license from Scandinavian Rheumatology Research Foundation.

Niu K.,Tohoku University | Ahola R.,University of Oulu | Guo H.,Tohoku University | Korpelainen R.,University of Oulu | And 12 more authors.
Journal of Bone and Mineral Metabolism | Year: 2010

Although there is ample evidence supporting the effectiveness of physical activity in the prevention and treatment of osteoporosis, there are no previous studies to examine the effect of office-based brief high-impact exercise (HIE) on bone mineral density (BMD) in healthy premenopausal women. This study evaluated the effects of office-based HIE on BMD in healthy premenopausal Japanese women. Ninety-one healthy premenopausal women were randomized to receive stretching exercise (SE) or HIE (stretching, along with up to 5 × 10 vertical and versatile jumps) for 12 months. The BMD of the lumbar spine and proximal femur was measured using dual-energy X-ray absorptiometry. Several cardiovascular risk factors and leg strength also were assessed. An accelerometer-based recorder was used to measure daily impact loading in four 1-week samples. The progression of the HIE program was ensured by the accelerometer. Thirty-three women (71.7%) in the SE group and 34 (75.6%) in the HIE group completed the study. There was a significant difference in the change in the femoral neck BMD between the groups in favor of the HIE group [0.6% (95% CI: -0.4, 1.7) vs. -1.0% (95% CI: -2.2, 0.2)]. Adiponectin, LDL, HDL, and the leg strength of participants in both the groups improved during the intervention. These finding suggested that office-based brief HIE can be recommended for premenopausal women for preventing bone mineral loss. © 2010 The Japanese Society for Bone and Mineral Research and Springer.

Kallio M.A.,University of Oulu | Kovala T.T.,Deaconess Institute of Oulu | Niemela E.N.K.,Raahe District Hospital | Huuskonen U.E.J.,University of Oulu | Tolonen E.U.,University of Oulu
Journal of Clinical Neurophysiology | Year: 2011

The finding of isolated teres minor denervation during examination of the shoulders using MRI occurs in 3% to 5.5% of examinations. We describe eight patients with shoulder pain, in whom electromyography revealed an isolated lesion in the motor branch of the axillary nerve to the teres minor muscle. This nerve lesion is clinically impossible to diagnose, the lack of a clear diagnosis often resulting in inappropriate treatment and therefore potentially prolonged disability. Hence, when encountering shoulder problems, neurophysiologists should examine the teres minor muscle as a matter of routine. In the MRI and ultrasound examinations of patients with shoulder problems, therefore, not only routine tendon and joint structure but also muscles should be evaluated. Copyright © 2011 by the American Clinical Neurophysiology Society.

Ahola R.,University of Oulu | Korpelainen R.,University of Oulu | Korpelainen R.,Deaconess Institute of Oulu | Vainionpaa A.,University of Oulu | Jamsa T.,University of Oulu
Journal of Biomechanics | Year: 2010

Mechanical loading increases and maintains bone mass and strength. Daily stress stimulus and osteogenic index theories have been suggested to describe the osteogenic potential of exercise, using exponential or logarithmic relationships, respectively, between loading numbers and magnitude. Inspired by these theories, the aim of this study was to develop and test a daily impact score (DIS) using long-term continuous acceleration measurements of exercise. Acceleration data were collected during a previous exercise trial, in which the subjects (healthy women, 35-40 years, N=34 in the high-impact exercise group and N=30 in the control group) wore a body movement monitor on their waist during the 12-month study. DIS was calculated from the 12-month average daily acceleration distributions in two ways: DISExp adopted from the daily stress stimulus and DISLog simplified from the osteogenic index. Areal bone mineral density (aBMD) at the proximal femur and cortical bone geometry at the mid-femur were measured at baseline and 12 months. DIS calculated in either of the ways was significantly higher in the exercise group than in the control group. DISExp and DISLog were strongly correlated (R=0.982). Both DISExp and DISLog were significantly associated with 12-month aBMD changes at the hip (R up to 0.550, p<0.01) and geometry changes at the mid-femur (R up to 0.472, p<0.05) in the exercise group. DIS calculated either from exponential or logarithmic relationship can be used in acceleration-based measurements of daily exercise. DIS was positively related with changes in hip aBMD and mid-femur bone geometry after 12 months of exercise. © 2010 Elsevier Ltd.

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