Ouachita Baptist University is a private, liberal arts, undergraduate institution located in Arkadelphia, Arkansas, which is about 65 miles southwest of Little Rock. The university's name is taken from the Ouachita River, which forms the eastern campus boundary. It is affiliated with the Arkansas Baptist State Convention. The student body is approximately 45% male and 55% female. Wikipedia.
News Article | May 22, 2017
WASHINGTON — Sarah Huckabee Sanders does not want you to read this story. When Yahoo News asked the White House’s principal deputy press secretary if she was willing to be interviewed for an article about her life and increasingly high-profile role in the administration of President Trump, she declined and said she’d prefer it wasn’t written at all. “My job is to promote the president. Any profile should be on him,” Sanders said. Whether she likes it or not, Sanders has found herself in the spotlight. Earlier this month, she stood in for press secretary Sean Spicer behind the podium in the White House briefing room. Sanders delivered mocking media criticism and sarcasm with a Southern drawl, smile and permanently arched eyebrow. Her performance had reporters laughing along as she scolded them for questioning the president. Sanders’ stint as the public face of the Trump administration fueled rumors she could emerge on top of a potential shakeup in the West Wing press shop. It also coincided with the firing of FBI Director James Comey, which plunged the White House into scandal and left Sanders’ credibility bruised after her initial account of the dismissal was contradicted by Trump. She wasn’t willing to talk about herself, but Sanders’ family and colleagues were more forthcoming. They described her as a political prodigy and rising star. But that meteoric trajectory has now led Sanders to one of the most precarious positions in a wildly unstable White House. The Trump administration has seemingly faced a new scandal on an almost nightly basis, leaving the press shop scrambling to keep up with the stories. Amid this chaos, Spicer has defended Trump with multiple demonstrably false claims. And what has been Spicer’s reward for putting his well-regarded reputation on the line? There are numerous reports that Trump is considering firing Spicer. Sanders’ turns behind the podium intensified those rumors, although Spicer’s absence was the result of previously planned Naval Reserve duty. Deputy White House press secretary Sarah Huckabee Sanders speaks during the daily briefing at the White House in Washington, Wednesday, May 10, 2017. (AP Photo/Susan Walsh) Spicer did not respond to multiple requests for comment from Yahoo News about his future in the administration or his relationship with Sanders. Both Spicer and Sanders are accompanying Trump on his marathon first foreign trip. Whether or not Sanders gets a promotion, she is clearly one of Trump’s top surrogates. And some of her colleagues in the conservative world see that as a dangerous and unenviable occupation. Tim Miller, a political operative who has worked as a spokesman for the Republican National Committee and one of Trump’s 2016 GOP primary rivals, former Florida Gov. Jeb Bush, told Yahoo News he’s aware of “plenty of people out there who have turned down opportunities to work in the communications department at the White House because they respected their [own] credibility.” “I think that as long as the president is going to put his spokespeople in this situation where they need to advance preposterous lies in order to prove their loyalty, I don’t know why anyone would want the job,” Miller said. At the podium, Sanders displays sweetness along with a sharp edge. For her first on-camera briefing on May 5, she wore a neon-pink dress and followed up her initial announcement with a joke to break the ice before the flood of questions began. “Finally, on a much lighter note, I wanted to make sure to note that everyone at the Department of Interior is having their first ever Bring Your Dog to Work Day, becoming the first federal department to go dog-friendly,” she said with evident enjoyment. “If anyone is up for a field trip later, just let me know, because I’m pretty sure that everybody here could use a little stress reliever,” said Sanders. The first reporter she called on responded with “welcome to the podium.” “Thank you,” Sanders said beaming. “Does that mean you’re going to be super nice today right?” Those closest to Sanders describe her as someone whose life has prepared her well for a fight. Sanders, who is 34 years old, was, quite literally, born into politics. She is the only daughter of the former Arkansas governor and two-time presidential candidate Mike Huckabee. In a phone conversation with Yahoo News, Huckabee said he’s “very proud” to see his daughter facing off against the relentless White House press corps. “I especially enjoy watching her hold her own and having such confidence. I mean she goes into that press room, like, wearing Lady Gaga’s meat suit and walking over to the zoo in the tiger cage,” Huckabee said with a laugh. “But she handles herself, I think, very well.” Huckabee said Sanders displayed early interest in political campaigning and strategizing. “From the time she was just a little kid … when other elementary school kids were outside playing chase and jumping rope, she was sitting at the kitchen table listening to Dick Morris do poll results and analyzing cross-tabs,” said Huckabee. Huckabee credits his daughter with having a toughness he attributes to her childhood in the political spotlight and “growing up with two older brothers who weren’t always gentle with her.” One of those brothers, David, said Sanders had to develop a thick skin when the family moved from Texarkana, Ark., to the state capital, Little Rock, after Huckabee became governor in 1996. Huckabee’s rise was something of a shock. He became lieutenant governor in a major upset. It was mostly a ceremonial position, and he didn’t bother uprooting his family for it. However, he ended up in the governor’s mansion after his Democratic predecessor was convicted of arranging fraudulent loans linked to the Whitewater scandal. The move came just as Sanders was set to start high school, and, David said, along with the state’s political establishment, most of the new neighbors were Democrats. “There was a lot of hostility” to the Republican newcomers. But Sanders flourished. As a high school senior, she was voted “most outstanding in service,” and the yearbook shows she participated in a number of class organizations, including “Quill and Scroll,” which was identified as “the international honorary society for high school journalists.” The yearbook noted membership in the society was reserved for students “in the upper third of their class scholastically” who were “recommended by their journalism teacher.” Sanders told Yahoo News she has no memory of doing journalism in high school. According to David, Sanders was something of a daddy’s girl. He described her simply as “the chosen one” in their family. Mike Huckabee, who was a pastor before running for office, doesn’t dispute the characterization. “She is the only girl, and the youngest, and unquestionably spoiled,” he said. Sanders didn’t go far away from her family for college. She attended Ouachita Baptist University in Arkadelphia. It’s about 70 miles away from the governor’s mansion. The trip led to Sanders’ first adult political battle. It was against her father. In 2002, both of Sanders’ parents were on the ballot in Arkansas. Her father was up for reelection, and her mother, Janet, was running for secretary of state. A local judge in Arkadelphia voided the ballots from 912 out-of-town students, including Sanders. The students filed a lawsuit with the support of the American Civil Liberties Union, and Sanders was one of the lead plaintiffs. Her father was, technically, the defendant. “She sued me because I encouraged her to,” Huckabee said. “And I encouraged her to go to the ACLU. I said, ‘Normally, I hate those people, but this is a case they will do.’” A judge ruled in favor of the students. After college, Sanders began her career as a political operative in earnest. She worked on President George W. Bush’s reelection campaign and was one of the top advisers for her father’s 2008 White House bid. For Huckabee, his daughter was invaluable because she was one of the few people who was “utterly comfortable” telling him he made a mistake. On her father’s campaign, Sanders supervised multiple staffers and volunteers in the field while doing everything from blogging to debate prep. Sanders was already deploying the blend of humor and disdain that she would go on to use behind the White House podium. In December 2007, the Chicago Tribune quoted her firing back at a Democratic operative who visited an event at a shopping center and questioned whether Huckabee had enough resources to win the Republican nomination for president. “He knows that from one visit to the mall?” Sanders quipped. Several people who’ve worked with Sanders attribute her flair for cheerful scorn to her Southern roots. “It’s somewhat typical of Southern women who, in many ways, grow up and have to be … tender outside but tough on the inside,” Huckabee explained. “And I’ve always said, when a Southern woman starts a sentence with ‘Bless your heart,’ you better be ready, because you’re about to be filleted.” In 2012, Sanders worked for Tim Pawlenty’s presidential campaign. The former Minnesota governor took note of Sanders’ ability to be “both strong and likable” and said it has served her well as a White House spokeswoman. “She … has difficult interactions with journalists, and that’s part of the grand journalistic tradition,” Pawlenty said, adding that “she does it in a way that’s likable yet strong, and so I think that’s the perfect combination for that role.” Sanders has earned rave reviews for her campaign work. Veteran political consultant Ed Rollins, who was Huckabee’s 2008 campaign chairman, described her as “a first-rate operative” and “the No. 1 draft choice” for any race he “was ever involved in.” Pawlenty praised her as “just terrific.” “I just think she’s going to grow up to be a big player in politics,” predicted Rollins. “I would not be shocked if she ended up going back and running for something someday.” Sanders also found love on the trail. She married another operative, Bryan Sanders, whom she met when he worked on her father’s campaign. The pair have three children together. Those who know Sanders see Bryan’s political experience as an asset to their relationship, since it helps him understand her demanding and unpredictable White House schedule. In addition to her political consulting, Sanders worked at the Department of Education during the administration of President George W. Bush. She came onboard the Trump campaign early last year, a few weeks after her father ended his own brief flirtation with the race. “I have great respect for Gov. Mike Huckabee, and we have a mutual admiration for our wonderful families. It is great to have his daughter, Sarah, join the campaign,” Trump said in a statement. At the time, Trump was trying to woo evangelicals, who have long been a part of Huckabee’s base. Sanders nodded to religious Christians in her statement about deciding to join his campaign. “Mr. Trump is pro-life, pro-marriage and will appoint conservatives to the courts,” she said. Amid the constant infighting that plagued Trump’s White House bid, Sanders managed to be widely liked. She also has developed a good relationship with Trump and gets face time with him in the Oval Office. When she’s not in the room with Trump or filling in for Spicer, Sanders can generally be found in her own office, which is just outside the press secretary’s. Surrounded by her children’s artwork, Sanders fields questions from a steady stream of reporters and staffers who seek her counsel. On May 11, after her second on-camera briefing, Sanders found her father waiting outside. She brought Huckabee to the inner sanctum to meet with the president. “Every time I talk to him, he’ll say, ‘Huckabee, I like you. You’re a great guy. You’re terrific, but your daughter, she’s so much better. She’s so much better,’” Huckabee said of Trump. The press corps have also complimented Sanders for managing to put a friendlier face on Trump’s long-running feud with the media. During Sanders’ second briefing, on May 10, New York Times White House correspondent Maggie Haberman tweeted about how it was a departure from Spicer’s more combative approach. “Sanders obfuscates same as Spicer. Also does it without making deeply personal, petty, condescending,” Haberman wrote. But as Spicer’s shaky status shows, Trump is infamously fickle. In an administration split into several warring factions, no staffer’s position is truly secure. And earning the president’s approval can cost credibility. Sanders’ second on-camera briefing was the first one following the news of Comey’s firing. A pack of reporters crowded the briefing room to ask questions about the blockbuster announcement. The trouble came for Sanders when she offered reporters the “tick tock,” briefing room slang for the White House’s version of the moments leading up to the big news. Like Spicer and Vice President Mike Pence before her, Sanders insisted Trump decided to fire Comey after deputy Attorney General Rod Rosenstein came to the president with a recommendation. But in an interview with NBC News the next day, Trump insisted he had already decided to get rid of Comey and would have done so “regardless of recommendation.” This contradiction led to extensive clarifications and questions about credibility in the briefing room. While Sanders’ start behind the podium was well-received, this discrepancy was a clear stumble. Miller, the Republican operative who said he knew colleagues who rejected White House communications jobs, suggested it overshadowed Sanders’ prior performance. “I was a little confused by the positive reviews given that she went out with a preposterous lie about why President Trump fired James Comey,” said Miller. Rollins, the consultant who worked with Sanders on her father’s campaign, said she and Spicer have “two of the toughest jobs in this White House.” “You’re dealing with all type A personalities in the media, you know, the very best in the media. It’s an adversarial role. And this is not a White House that’s always been on the same page, because they don’t know where the president is and because he’s not always on the same page.” A press deputy from the second Bush administration similarly said Spicer and Sanders are in a very difficult position and blamed it squarely on Trump. “Whatever is happening there in the press office is a symptom of a larger issue of how the president of the United States comports himself,” said the deputy. “When your boss is making it difficult and nearly impossible for you to stand at the podium and take all of those questions, it becomes a nearly impossible task.” The deputy, who requested anonymity due to having moved on to a corporate job, cited several reasons it’s difficult to represent Trump in the briefing room. First, the deputy said it’s essential for press staff to know the president’s “track record” on various issues to understand their “perspective” and “philosophy.” This is trickier with Trump since he has no prior political experience. The deputy also noted Trump’s propensity to give “mixed answers” and change his story as he did in the wake of Comey’s firing. “When you’re out on a limb saying one thing to try to bolster the president’s position and he personally saws the limb off behind you, it makes it so hard to do your job,” the deputy said. There is something of a fraternity of former White House press secretaries and staffers that crosses party lines. Many of them are in touch, and the Trump team’s performance is a prime topic of conversation, the deputy said, adding that the West Wing veterans have a uniform reaction to Spicer and Sanders. Sanders declined to be interviewed for this story, but she did answer one key question. Is she concerned working for Trump will cost her credibility? Sitting in an office decorated with her children’s artwork, Sanders let loose something between a laugh and an exasperated sigh as she dismissed the question.
News Article | April 17, 2017
LearnHowToBecome.org, a leading resource provider for higher education and career information, has announced its list of the best colleges and universities in Arkansas for 2017. 20 four-year schools made the list, with John Brown University, Hendrix College, Ouachita Baptist University, Harding University and University of Arkansas taking the lead as the top five. Of the 26 two-year schools that were also included, North Arkansas College, Arkansas State University Mountain Home, Black River Technical College, Pulaski Technical College and Arkansas Northeastern College were the top five. A full list of winning schools is included below. “Arkansas is seeing a record low for unemployment in 2017, which is great news for college grads entering the job market,” said Wes Ricketts, senior vice president of LearnHowToBecome.org. “The schools on our list have demonstrated value for not only providing a strong education, but also helping students fulfill career goals after they graduate.” To be included on Arkansas “Best Colleges” list, schools must be regionally accredited, not-for-profit institutions. Each college is also scored on additional data that includes annual alumni earnings 10 years after entering college, career services offered, availability of financial aid and base metrics such as student/teacher ratios and graduation rates. Complete details on each college, their individual scores and the data and methodology used to determine the LearnHowToBecome.org “Best Colleges in Arkansas” list, visit: The Best Four-Year Colleges in Arkansas for 2017 include: Arkansas State University-Main Campus Arkansas Tech University Central Baptist College Harding University Henderson State University Hendrix College John Brown University Lyon College Ouachita Baptist University Philander Smith College Southern Arkansas University Main Campus University of Arkansas University of Arkansas at Little Rock University of Arkansas at Monticello University of Arkansas at Pine Bluff University of Arkansas for Medical Sciences University of Arkansas-Fort Smith University of Central Arkansas University of the Ozarks Williams Baptist College The Best Two-Year Colleges in Arkansas for 2017 include: Arkansas Northeastern College Arkansas State University - Beebe Arkansas State University - Mountain Home Arkansas State University - Newport Baptist Health Schools-Little Rock Black River Technical College College of the Ouachitas Cossatot Community College of the University of Arkansas Crowley's Ridge Technical Institute East Arkansas Community College Mid-South Community College National Park College North Arkansas College NorthWest Arkansas Community College Northwest Technical Institute Ozarka College Phillips Community College Pulaski Technical College Remington College-Little Rock Campus Rich Mountain Community College South Arkansas Community College Southeast Arkansas College Southern Arkansas University Tech University of Arkansas Community College - Batesville University of Arkansas Community College - Morrilton University of Arkansas Hope - Texarkana Arkansas Northeastern College About Us: LearnHowtoBecome.org was founded in 2013 to provide data and expert driven information about employment opportunities and the education needed to land the perfect career. Our materials cover a wide range of professions, industries and degree programs, and are designed for people who want to choose, change or advance their careers. We also provide helpful resources and guides that address social issues, financial aid and other special interest in higher education. Information from LearnHowtoBecome.org has proudly been featured by more than 700 educational institutions.
News Article | February 28, 2017
LITTLE ROCK, AR, February 28, 2017-- Evelyn Elizabeth Hughes-Bass has been included in Marquis Who's Who. As in all Marquis Who's Who biographical volumes, individuals profiled are selected on the basis of current reference value. Factors such as position, noteworthy accomplishments, visibility, and prominence in a field are all taken into account during the selection process.Drawing upon more than 40 years of experience in public and private Christian school in education, and early childhood coordinator for Arkansas Education Television Network (AETN) training and developing workshop for parents and children.Ms. Bass began her career in education upon her graduation from Arkansas Baptist College with a Bachelor of Arts in 1971. From there, Ms. Bass served as a teacher with Pulaski County Special School District while pursuing a Master of Science in education at Ouachita Baptist University, which she completed in 1988. Ms. Bass has also attended postgraduate studies through Harding University in education leadership.Between 1997 and 2004, Ms. Bass served as director/teacher of Lenea's Children Cottage. She also served as a preschool teacher with Graceland Kid's Educare Center.In recognition of her commitment to education, Ms. Bass has been featured in numerous honors publications, including Who's Who in America, Who's Who of American Women and Who's Who in the World. She was also selected for inclusion in the 7th and 8th editions of Who's Who in American Education, which were published in 2005 and 2007, respectively. Ms. Bass maintains involvement with a wide range of educational organizations, including the Southern Early Childhood Association (SECA), AR Kids Read and Arkansas Retired Teacher Association (ARTA). In her spare time, she serves as a consultant in her field, as well as a composer of music, and vocalist of praises and hymns. Since 1999, Ms. Bass has served as an advisor for child development and associate instructor with Grace Holiness Christian Academy. Ms. Bass presently works in the capacity of an independent certified advanced trainer for the Early Care and Education Projects, conducting workshops in the field of early childhood education, at University of Arkansas at Fayetteville.Ms. Bass published a children music book entitled, "Never Say Never" and a CD; these motivating songs can be purchased through Author House, Barnes&Noble, Amazon, xulon, and arbor spring. Her book "Listen! The Lord is Speaking," which was released in 2004, was written to inspire and encourage readers.About Marquis Who's Who :Since 1899, when A. N. Marquis printed the First Edition of Who's Who in America , Marquis Who's Who has chronicled the lives of the most accomplished individuals and innovators from every significant field of endeavor, including politics, business, medicine, law, education, art, religion and entertainment. Today, Who's Who in America remains an essential biographical source for thousands of researchers, journalists, librarians and executive search firms around the world. Marquis publications may be visited at the official Marquis Who's Who website at www.marquiswhoswho.com
News Article | February 15, 2017
Louis W. Heard’s new book, Closer Devotional ($20.99, paperback, 9781498480123; $9.99, eBook, 9781498480130) provides people a discipleship tool and plan for drawing closer to God on a daily basis. Heard’s hope is to put Biblical knowledge into action, increasing relevance and adventure in regard to a believer's faith in Jesus. The devotional will encourage readers to gain a closer, more intimate walk with Jesus, and they will walk away each day experiencing God in a fresh way. After reading and applying this book (using the Closer Challenges), the reader cannot remain the same spiritually. Not only will they be closer to God, but they will be closer to others too! Heard says, “From what I can tell, there is no other devotional quite like this one. It's not just a collection of warm, spiritual thoughts for the day; it's a plan for radically applying God's word to everyday life.” Louis W. Heard has been in Christian ministry since 1995. He has a BA in Biblical Studies/Language from Ouachita Baptist University and a Master of Divinity from Southwestern Baptist Theological Seminary. He has over ten years’ experience of being a Lead Pastor in growing churches. Heard is currently the pastor at Grace Baptist Church in Fort Worth, Texas, which has almost doubled in size since he arrived over 3 years ago, they have close to 550 in average worship attendance. Xulon Press, a division of Salem Media Group, is the world’s largest Christian self-publisher, with more than 12,000 titles published to date. Retailers may order Closer Devotional through Ingram Book Company and/or Spring Arbor Book Distributors. The book is available online through xulonpress.com/bookstore, amazon.com, and barnesandnoble.com.
Levy J.W.,Ouachita Baptist University |
Hartman J.H.,University of Arkansas for Medical Sciences |
Perry M.D.,Ouachita Baptist University |
Miller G.P.,University of Arkansas for Medical Sciences
Journal of Molecular Graphics and Modelling | Year: 2015
CYP2E1 metabolizes a wide array of small, hydrophobic molecules, resulting in their detoxification or activation into carcinogens through Michaelis-Menten as well as cooperative mechanisms. Nevertheless, the molecular determinants for CYP2E1 specificity and metabolic efficiency toward these compounds are still unknown. Herein, we employed computational docking studies coupled to molecular dynamics simulations to provide a critical perspective for understanding a structural basis for cooperativity observed for an array of azoles from our previous binding and catalytic studies (Hartman et al., 2014). The resulting 28 CYP2E1 complexes in this study revealed a common passageway for azoles that included a hydrophobic steric barrier causing a pause in movement toward the active site. The entrance to the active site acted like a second sieve to restrict access to the inner chamber. Collectively, these interactions impacted the final orientation of azoles reaching the active site and hence could explain differences in their biochemical properties observed in our previous studies, such as the consequences of methylation at position 5 of the azole ring. The association of a second azole demonstrated significant differences in interactions stabilizing the bound complex than observed for the first binding event. Intermolecular interactions occurred between the two azoles as well as CYP2E1 residue side chains and backbone and involved both hydrophobic contacts and hydrogen bonds. The relative importance of these interactions depended on the structure of the respective azoles indicating the absence of specific defining criteria for binding unlike the well-characterized dominant role of hydrophobicity in active site binding. Consequently, the structure activity relationships described here and elsewhere are necessary to more accurately identify factors impacting the observation and significance of cooperativity in CYP2E1 binding and catalysis toward drugs, dietary compounds, and pollutants. © 2014 Elsevier Inc. All rights reserved.
Hartmann P.,Hungarian Academy of Sciences |
Hartmann P.,Baylor University |
Kovacs A.Z.,Hungarian Academy of Sciences |
Douglass A.M.,Ouachita Baptist University |
And 3 more authors.
Physical Review Letters | Year: 2014
We report complex plasma experiments, assisted by numerical simulations, providing an alternative qualitative link between the macroscopic response of polycrystalline solid matter to small shearing forces and the possible underlying microscopic processes. In the stationary creep regime we have determined the exponents of the shear rate dependence of the shear stress and defect density, being α=1.15±0.1 and β=2.4±0.4, respectively. We show that the formation and rapid glide motion of dislocation pairs in the lattice are dominant processes. © 2014 American Physical Society.
Hartman J.H.,University of Arkansas for Medical Sciences |
Bradley A.M.,Vanderbilt University |
Laddusaw R.M.,Texas A&M University |
Perry Jr. M.D.,Ouachita Baptist University |
Miller G.P.,University of Arkansas for Medical Sciences
Archives of Biochemistry and Biophysics | Year: 2013
CYP2E1 plays a critical role in detoxification and carcinogenic activation of drugs, pollutants, and dietary compounds; however, these metabolic processes can involve poorly characterized cooperative interactions that compromise the ability to understand and predict CYP2E1 metabolism. Herein, we employed an array of ten azoles with an emphasis on pyrazoles to establish the selectivity of catalytic and cooperative CYP2E1 sites through binding and catalytic studies. Spectral binding studies for monocyclic azoles suggested two binding events, while bicyclic azoles suggested one. Pyrazole had moderate affinity toward the CYP2E1 catalytic site that improved when a methyl group was introduced at either position 3 or 4. The presence of methyl groups simultaneously at positions 3 and 5 blocked binding, and a phenyl group at position 3 did not improve binding affinity. In contrast, pyrazole fusion to a benzene or cyclohexane ring greatly increased affinity. The consequences of these binding events on CYP2E1 catalysis were studied through inhibition studies with 4-nitrophenol, a substrate known to bind both sites. Most pyrazoles shared a common mixed cooperative inhibition mechanism in which pyrazole binding rescued CYP2E1 from substrate inhibition. Overall, inhibitor affinities toward the CYP2E1 catalytic site were similar to those reported in binding studies, and the same trend was observed for binding at the cooperative site. Taken together, these studies identified key structural determinants in the affinity and stoichiometry of azole interactions with CYP2E1 and consequences on catalysis that further advance an understanding of the relationship between structure and function for this enzyme. © 2013 Elsevier Inc. All rights reserved.
Kolt R.P.,Ouachita Baptist University
National Identities | Year: 2015
Nationalism in Western art music has long been a source of intense controversy. Scholars have struggled to provide an adequate definition of the phenomenon with varying degrees of success; principally because it has always been assumed that the national in music must include purely musical elements in its definition. This assumption has led to often grossly inadequate ideas about how nationalism in music is created by a composer and perceived by a listener. A brief review and reassessment of traditional attempts to define nationalism in music may shed new light on the aesthetic realties of the national in music. © 2014, © 2014 Taylor & Francis.
Burns S.A.,University of Arkansas for Medical Sciences |
Lee Archer R.,University of Arkansas for Medical Sciences |
Chavis J.A.,University of Arkansas for Medical Sciences |
Tull C.A.,Ouachita Baptist University |
And 2 more authors.
Brain Research | Year: 2012
Mitoxantrone has been approved by the FDA for the treatment of multiple sclerosis (MS). However, the mechanisms by which mitoxantrone modulates MS are largely unknown. Activated astrocytes produce nitric oxide (NO), TNF-α, and IL-1β, molecules which can be toxic to central nervous system (CNS) cells including oligodendrocytes, thus potentially contributing to the pathology associated with MS. MCP-1 is a chemokine believed to modulate the migration of monocytes to inflammatory lesions present in the CNS of MS patients. IL-12 and IL-23 have been demonstrated to play critical roles in the pathogenesis of experimental autoimmune encephalomyelitis (EAE), an animal model of MS, by contributing to the development of CD4 T cell lineages termed Th1 and Th17, respectively. The current study demonstrates that mitoxantrone inhibits lipopolysachharide (LPS) induction of NO, TNF-α, IL-1β, and MCP-1 production by primary astrocytes. Mitoxantrone also inhibited IL-12 and IL-23 production by these cells. Furthermore, mitoxantrone suppressed the expression of C-reactive protein (CRP). Finally, we demonstrate that mitoxantrone suppressed LPS induction of NF-κB DNA-binding activity, suggesting a novel mechanism by which mitoxantrone suppresses the expression of proinflammatory molecules. Collectively, these studies demonstrate that mitoxantrone represses astrocyte production of potentially cytotoxic molecules, as well as molecules capable of altering T-cell phenotype. These in vitro studies suggest mechanisms by which mitoxantrone may modulate inflammatory diseases including MS. © 2012 Elsevier B.V. All rights reserved.
News Article | February 23, 2017
The oil and gas industry is always innovating and for related trades, like transportation, it is important to keep up. That is why Arrows Up, LLC., an affiliate of OmniTRAX Inc., has introduced a revolutionary method to get frac sand into the blender at the wellhead in a way that eliminates dust, saves time and cuts costs. “Anyone who has ever fracked a well knows there are a million things to consider when it comes to safety, costs and efficiencies,” said Ken White, Director of Sales for Arrows Up, LLC. “Our system makes their job easier by providing a last-mile containerized proppant delivery solution that addresses all three of those business priorities.” Speaking at the North American Frac Sand Exhibition & Conference, today, White will explain how their delivery solution combines unitized Jumbo Bins with a riser that allows the sand to be directly discharged into the blender at the wellhead. This flexible system offers tailored solutions that customers love because it reduces transportation costs and demurrage without compromising safety. In fact, the patent-pending containers are proven to substantially reduce silica dust, which is heavily regulated by the National Institute for Occupational Safety and Health (NIOSH). The Arrows Up Jumbo Bin can hold 25 tons of frac sand and decrease product shrinkage by reducing the number of times the product needs to be transferred. It can also be moved by standard transportation equipment, giving customers the flexibility they need to control costs. White’s presentation is entitled: “Creating Supply Chain Efficiencies Through Unitized Solutions for Last-Mile Delivery.” Ken White Bio: Ken White has been in Business Development and Product Integration for over 25 years. The last 5 years he has been providing proppants to the oil and gas industry nationwide. He has an extensive background in all types of proppants from ceramic proppant, resin coated proppant, as well as northern and southern sands. He has been heavily involved in understanding the importance of the integrity of these products, which includes logistics and delivery to the blender. Ken joined Arrows UP, LLC in 2017 as the Director of Sales and has been tasked the role of growing the Arrows Up footprint. Ken attended Ouachita Baptist University as a Business Major in Arkadelphia, Arkansas. About OmniTRAX, Inc. As one of North America’s largest private railroad and transportation management companies, OmniTRAX’s core capabilities range from providing management services to railroad and port services and to intermodal and industrial switching operations. Through its affiliation with The Broe Group and its portfolio of managed companies, OmniTRAX also has the unique capability of offering specialized industrial development and real estate solutions, both on and off the rail network managed by OmniTRAX. More information is available at http://www.omnitrax.com. About Arrows Up, LLC. Arrows Up, LLC. began following a company’s request to create better products to serve the bulk storage and transportation industry. The management and operations teams of Arrows Up have over 65 years of combined experience in the packaging and logistics industry. Our mission is to create innovative, efficient and safer solutions for the bulk storage and transportation industries. This will be accomplished by research, customer involvement and continued experimentation with materials, design and assemble concepts. More information is available at http://www.arrowsupllc.com/.