Magdeburg, Germany

The Otto-von-Guericke University Magdeburg was founded in 1993 and is one of the youngest universities in Germany. The university in Magdeburg has about 14,000 students in nine faculties. There are 11,700 papers published in international journals from this institute.It is named after the physicist Otto von Guericke, famous for his experiments with the Magdeburg hemispheres.The former Technical University Magdeburg , a teacher training college and a medical school were absorbed into the university when it was created. The university now composes nine faculties.Raila Odinga, a former Prime Minister of Kenya, is an alumnus of the Technical University. Professor Dr. Nguyen Thien Nhan, Vietnam's current Deputy Prime Minister and Minister of Education & Training, is also an alumnus of the Technical University. Dr. Rumiana Jeleva, former Minister of Foreign Affairs of Bulgaria , earned a PhD degree in sociology at the Otto-von-Guericke University Magdeburg. Wikipedia.

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Agency: European Commission | Branch: H2020 | Program: RIA | Phase: MG-3.6a-2015 | Award Amount: 9.61M | Year: 2016

ADAS&ME (Adaptive ADAS to support incapacitated drivers &Mitigate Effectively risks through tailor made HMI under automation) will develop adapted Advanced Driver Assistance Systems, that incorporate driver/rider state, situational/environmental context, and adaptive interaction to automatically transfer control between vehicle and driver/rider and thus ensure safer and more efficient road usage. To achieve this, a holistic approach will be taken which considers automated driving along with information on driver/rider state. The work is based around 7 provisionally identified Use Cases for cars, trucks, buses and motorcycles, aiming to cover a large proportion of driving on European roads. Experimental research will be carried out on algorithms for driver state monitoring as well as on HMI and automation transitions. It will develop robust detection/prediction algorithms for driver/rider state monitoring towards different driver states, such as fatigue, sleepiness, stress, inattention and impairing emotions, employing existing and novel sensing technologies, taking into account traffic and weather conditions via V2X and personalizing them to individual drivers physiology and driving behaviour. In addition, the core development includes multimodal and adaptive warning and intervention strategies based on current driver state and severity of scenarios. The final outcome is the successful fusion of the developed elements into an integrated driver/rider state monitoring system, able to both be utilized in and be supported by vehicle automation of Levels 1 to 4. The system will be validated with a wide pool of drivers/riders under simulated and real road conditions and under different driver/rider states; with the use of 2 cars (1 conventional, 1 electric), 1 truck, 2 PTWs and 1 bus demonstrators. This challenging task has been undertaken by a multidisciplinary Consortium of 30 Partners, including an OEM per vehicle type and 7 Tier 1 suppliers.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: ICT-22-2016 | Award Amount: 2.87M | Year: 2017

The STORIES project aims to contribute to a dynamic future of childrens ebooks evolution by a) developing user-friendly interfaces for young students (10-12 years old) to create their own multi-path stories expressing their imagination and creativity and b) by integrating the latest AR, VR and 3D printing technologies to visualize their stories in numerous innovative ways. In the heart of this intervention lies the vision for integrated curricula and deeper learning outcomes. The project will offer these innovations through a single environment, the STORIES Storytelling Platform which will be the place for students artistic expression and scientific inquiry at the same time. The creations of the students (paintings, models, dioramas and constructions, 3D objects and landscapes, animations, science videos and science theatre plays) will be captured and integrated in the form of interactive ebooks. The STORIES technical team will design advanced interfaces in which students will be able to augment characters, buildings, greenhouses and different 3D geometrical structures on a tablet or their computer and inspect their work using a mobile device. The outcome of their work will be detected and tracked, and the video stream is augmented with an animated 3D version of the character or the artefact. The platform will be tested in real settings in Germany, Greece, Portugal, France, Finland and Japan, involving 60 teachers and 3000 students (5th and 6th grade). To achieve this, the proposed project is developing a novel cooperation between creative industries and electronic publishing, educational research institutions in the field of STEM, schools and informal learning centres. The consortium includes 15 partners from Europe, USA, Japan and Australia. But STORIES is going beyond that: The consortium will cooperate in the design of the platform and in the development of the storyline mechanism with Eugene (Eugenios) Trivizas, well known writer of childrens books.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: SC1-PM-04-2016 | Award Amount: 7.35M | Year: 2017

Over 130,000 children born in Europe every year will have a congenital anomaly (CA; birth defect). These CAs, which are often rare diseases, are a major cause of infant mortality, childhood morbidity and long-term disability. EUROCAT is an established European network of population-based registries for the epidemiologic surveillance of CAs. EUROlinkCAT will use the EUROCAT infrastructure to support 21 EUROCAT registries in 13 European countries to link their CA data to mortality, hospital discharge, prescription and educational databases. Each registry will send standard aggregate tables and analysis results to a Central Results Repository (CRR) thus respecting data security issues surrounding sensitive data. The CRR will contain standardised summary data and analyses on an estimated 200,000 children with a CA born from 1995 to 2014 up to age 10, enabling hypotheses on their health and education to be investigated at an EU level. This enhanced information will allow optimisation of personalised care and treatment decisions for children with rare CAs. Registries will be supported in using social media platforms to connect with families who live with CAs in their regions. A novel sustainable e-forum, ConnectEpeople, will link these families with local, national and international registries and information resources. ConnectEpeople will involve these families in setting research priorities and ensuring a meaningful dissemination of results. Findings will provide evidence to inform national treatment guidelines, such as concerning screening programs, to optimise diagnosis, prevention and treatment for these children and reduce health inequalities in Europe. An economic evaluation of the hospitalisation costs associated with CA will be provided. The CRR and associated documentation, including linkage and standardisation procedures and ConnectEpeople forum will be available post-EUROlinkCAT thus facilitating future local and EU level analyses.

Alcohol addiction ranks among the primary global causes of preventable death and disabilities in human population, but treatment options are very limited. Rational strategies for design and development of novel, evidence based therapies for alcohol addiction are still missing. Within this project, we will utilize a translational approach based on clinical studies and animal experiments to fill this gap. We will provide a novel discovery strategy based on systems biology concepts that uses mathematical and network theoretical models to identify brain sites and functional networks that can be targeted specifically by therapeutic interventions. To build predictive models of the relapse-prone state of brain networks we will use magnetic resonance imaging and neurochemical data from patients and laboratory animals. The mathematical models will be rigorously tested through experimental procedures aimed to guide network dynamics towards increased resilience. We expect to identify hubs that promote relapse-proneness and to predict how aberrant network states could be normalized. Proof of concept experiments in animal will need to demonstrate this possibility by showing directed remodeling of functional brain networks by targeted interventions prescribed by the theoretical framework. Thus, our translational goal will be achieved by a theoretical and experimental framework for making predictions based on fMRI and mathematical modeling, which is verified in animals, and which can be transferred to humans. To achieve this goal we have assembled an interdisciplinary consortium (eight European countries) of world-class expertise in all complementary skills required for the project. If successful this project will positively impact on the development of new therapies for a disorder with largely unmet clinical needs, and thus help to address a serious and widespread health problem in our societies.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: SC1-PM-09-2016 | Award Amount: 6.20M | Year: 2017

Due to lack of targeted interventions, compliance issues, insufficient effect sizes and a high non-responder rate to currently available interventions, there is an urgent need to develop innovative and new interventions for chronic paediatric neuropsychiatric disorders, such as Attention-Deficit/Hyperactivity Disorder (ADHD) and Autism Spectrum Disorder (ASD). Transcranial direct current stimulation (tDCS) has been shown to be an innovative, effective and safe alternative treatment approach for neuropsychiatric disorders in adults. Here, for the first time, the effect of tDCS on core neurocognitive and behavioral outcomes will be proven in children and adolescents. First, effect sizes and safety of standard tDCS in the clinical setting targeting core brain regions and disorder specific cognitive tasks will be established by three phase-IIa randomized, double blind, sham-controlled studies in ADHD and ASD. Second, the impact of brain development and age-dependent anatomical / functional features on effects of tDCS will be studied systematically using methods of modern neurophysiology, neuroimaging and electric current modeling. This involves an additional phase-I clinical trial. Third, mechanisms of tDCS on brain function will be studied, and biomarkers will be developed in order to predict individual response to standard and individualized stimulation protocols. Finally, the applicability of tDCS in children and adolescents will be improved by developing an innovative personalized home-based treatment option in combination with a telemental health service, which will be tested by a fifth, phase-IIa clinical trial. Throughout the entire project, ethical concerns of the target population will be addressed. This project opens a new avenue for the application of tDCS as an alternative treatment for a great number of chronic neuropsychiatric disorders in children and adolescents and will allow flexible integration of tDCS in the daily routine of families.

Cao H.,Yale University | Wiersig J.,Otto Von Guericke University of Magdeburg
Reviews of Modern Physics | Year: 2015

This is a review on theoretical and experimental studies on dielectric microcavities, which play a significant role in fundamental and applied research. The basic concepts and theories are introduced. Experimental techniques for fabrication of microcavities and optical characterization are described. Starting from undeformed cavities, the review moves on to weak deformation, intermediate deformation with mixed phase space, and then strong deformation with full ray chaos. Non-Hermitian physics such as avoided resonance crossings and exceptional points are covered along with various dynamical tunneling phenomena. Some specific topics such as unidirectional output, beam shifts, wavelength-scale microcavities, and rotating microcavities are discussed. The open microdisk and microsphere cavities are ideal model systems for the studies on wave chaos and non-Hermitian physics. © 2015 American Physical Society.

Several types of sensors used in physics are based on the detection of splittings of resonant frequencies or energy levels. We propose here to operate such sensors at so-called exceptional points, which are degeneracies in open wave and quantum systems where at least two resonant frequencies or energy levels and the corresponding eigenstates coalesce. We argue that this has great potential for enhanced sensitivity provided that one is able to measure both the frequency splitting as well as the linewidth splitting. We apply this concept to a microcavity sensor for single-particle detection. An analytical theory and numerical simulations prove a more than threefold enhanced sensitivity. We discuss the possibility to resolve individual linewidths using active optical microcavities. © 2014 American Physical Society.

Edelmann F.T.,Otto Von Guericke University of Magdeburg
Chemical Society Reviews | Year: 2012

Today the rare-earth elements play a critical role in numerous high-tech applications. This is why various areas of rare-earth chemistry are currently thriving. In organolanthanide chemistry the search for new ligand sets which are able to satisfy the coordination requirements of the large lanthanide cations continues to be a hot topic. Among the most successful approaches in this field is the use of amidinate and guanidinate ligands of the general types [RC(NR′) 2] - (R = H, alkyl, aryl; R′ = alkyl, cycloalkyl, aryl, SiMe 3) and [R 2NC(NR′) 2] - (R = alkyl, SiMe 3; R′ = alkyl, cycloalkyl, aryl, SiMe 3), which can both be regarded as steric cyclopentadienyl equivalents. Mono-, di- and trisubstituted lanthanide amidinate and guanidinate complexes are all readily available. Various rare earth amidinates and guanidinates have turned out to be very efficient homogeneous catalysts e.g. for the polymerization of olefins and dienes, the ring-opening polymerization of cyclic esters or the guanylation of amines. Moreover, certain alkyl-substituted lanthanide tris(amidinates) and tris(guanidinates) were found to be highly volatile and are thus promising precursors for ALD (= atomic layer deposition) and MOCVD (= metal-organic chemical vapor deposition) processes in materials science, e.g. for the production of lanthanide nitride thin layers. This tutorial review covers the continuing success story of lanthanide amidinates and guanidinates which have undergone an astonishing transition from mere laboratory curiosities to efficient homogeneous catalysts as well as ALD and MOCVD precursors within the past 10 years. This journal is © The Royal Society of Chemistry 2012.

Agency: European Commission | Branch: H2020 | Program: ERC-STG | Phase: ERC-2016-STG | Award Amount: 1.50M | Year: 2017

Pathogen proliferation has profound implications for its persistence, treatment strategies, and the induction and execution of protective immune responses. In vivo, pathogen proliferation rates are heterogenic, confronting the immune system with a variety of microbial physiological states. It is unknown if, and by what molecular mechanism, the immune response can distinguish these different states on a cellular level. Also, understanding the link between pathogen proliferation and immune cell dynamics could provide critical information on how infections can be controlled, and how to counteract pathogen persistence and antibiotic resistance. However, this question has never been addressed due to difficulties in studying the dynamics of immune cells and at the same time probing pathogen proliferation. In this project, we will make use of a novel in vivo reporter system that I have developed, in order to determine the role of the pathogens proliferation for its interaction with the immune system. Specifically, we will (1) determine the tissue niche in which the pathogen proliferates, (2) investigate the differential dynamics of phagocyte-pathogen- and of T cell-APC-interactions related to pathogen proliferation rate, (3) manipulate the relationship between pathogen proliferation and immune cell dynamics by using proliferation-deficient mutants and optogenetic pathogen inactivation, (4) identify signaling pathways that are differentially induced in cells infected by high versus low proliferating pathogens, and test their involvement in differential immune cell dynamics related to pathogen proliferation. ImmProDynamics will for the first time provide insights into how cells of the immune system react to distinct pathogen proliferative states in vivo. This will greatly expand our knowledge of host-pathogen interactions, which will be critical for the design of efficient vaccines and antimicrobial therapy.

Agency: European Commission | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2015-ETN | Award Amount: 2.51M | Year: 2017

Over recent years the ubiquity of mobile platforms such as smartphones and tablets devices has rapidly increased. These devices provide a range of untethered interaction unimaginable a decade previously. With this ability to interact with services and individuals comes the need to accurately authenticate the identity of the person requesting the transaction many of which carry financial/legally-binding instruction. Biometric solutions have also seen increased prominence over the past decade with large-scale implementations in areas such as passport and national ID systems. The adoption of specific biometric sensors by mobile vendors indicates a long-term strategy as a means of authentication. This adoption is is at critical point users need to be confident of biometrics in terms of usability, privacy and performance; compromise in any one of these categories will lead to mistrust and a reluctance to adopt over and above conventional forms of authentication. The design, implementation and assessment of biometrics on mobile devices therefore requires a range of solutions to aid initial and continued adoption. The EU needs to have experts trained specifically in the field to ensure that it participates, competes and succeeds in the global market. AMBER comprises 11 partners with recognised expertise from across the EU. The specific objectives are to: Address a range of current issues facing biometric solutions on mobile devices requiring timely research and development. Collate Europe-wide complementary expertise to investigate these issues and provide a structure and environment to effectively facilitate training. Train and equip the next generation of researchers to define, investigate and implement solutions, and provide transferable skills to enable effective planning, management and communication of research ideas and outcomes. Develop solutions and theory to ensure secure, ubiquitous and efficient authentication whilst protecting privacy of citizen.

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