Otsuka Pharmaceutical Factory Inc.

Naruto, Japan

Otsuka Pharmaceutical Factory Inc.

Naruto, Japan
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[Object] An object of the present invention is to provide an oral solid preparation that can be produced in a simpler manner than conventional methods, that exhibits high bioavailability and high dissolubility even in persons having low stomach acid, and that can also ensure dissolubility after being allowed to stand for a certain period of time. Another object is to provide a simple method for producing the oral solid preparation. [Means for Achieving the Object] The present invention relates to an oral solid preparation comprising, as an active ingredient, a finely milled powder obtained by milling a highly hygroscopic aripiprazole anhydrous crystal, and a pharmaceutically acceptable carrier, the finely milled powder having a mean particle size of 10 m or less; and a method for producing an oral solid preparation comprising the steps of (1) milling a highly hygroscopic aripiprazole anhydrous crystal into a finely milled powder having a mean particle size of 10 m or less, and (2) mixing the obtained finely milled powder with a pharmaceutically acceptable carrier.


Patent
Otsuka Pharmaceutical Factory Inc. | Date: 2017-02-10

Provided is an aqueous pharmaceutical preparation comprising 7-[4-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)butoxy]-1H-quinolin-2-one (compound (I)) or a salt thereof, which shows improved water solubility of compound (I) or a salt thereof achieved by addition of substituted -cyclodextrin. The present invention provides a pharmaceutical preparation comprising compound (I) or a salt thereof, and substituted -cyclodextrin.


Patent
Otsuka Pharmaceutical Factory Inc. | Date: 2017-03-01

A major object of the present invention is to provide an effective means for promoting polyamine synthesis in an organism (in particular, in humans).


Patent
Otsuka Pharmaceutical Factory Inc. and Omori Machinery Co. | Date: 2017-03-07

An object is to provide a tablet manufacturing apparatus capable of supplying an IC chip to a desired position of pharmaceutical powder with a high accuracy and suppressing a positional displacement. The IC chip is supported by a positioning guide with a chip main body in a downward manner, and is held in a state of being positioned above pharmaceutical powder filled in a die hole before compression. The IC chip is supplied by a pusher.


Patent
Otsuka Pharmaceutical Factory Inc. and Lundbeck | Date: 2017-03-01

A medicament comprising (I) brexpiprazole or a pharmaceutically acceptable salt thereof, and (II) nalmefene or a pharmaceutically acceptable salt thereof in combination, wherein brexpiprazole or a pharmaceutically acceptable salt thereof, and nalmefene or a pharmaceutically acceptable salt thereof are contained in a single preparation, or a pharmaceutical composition containing brexpiprazole or a pharmaceutically acceptable salt thereof and a pharmaceutical composition containing nalmefene or a pharmaceutically acceptable salt thereof are formulated for use in combination. The medicament is used for the prophylaxis or treatment of a substance-related disorder, preferably an alcohol-related disorder.


Provided herein are formulations of (2,4-dihydroxy-5-isopropyl-phenyl)-[5-(4- methyl-piperazin-1-ylmethyl)-1,3-dihydro-isoindol-2-yl]-methanone of formula (I), or a L- lactate salt thereof, in a phosphate or succinate buffer.


Patent
Otsuka Pharmaceutical Factory Inc. | Date: 2017-01-11

Iohexol particles, contrast agent compositions comprising iohexol particles, methods of preparing iohexol particles, and methods of administering iohexol particles are provided herein. The iohexol particles of the present invention substantially dissolve in water within about 60 seconds when tested using Modified United States Pharmacopeia Method 641.


This invention relates to a tablet containing, as an active ingredient, 7-[4-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)butoxy]-1H-quinolin-2-one or a salt thereof, that has excellent disintegration ability, storage stability and photostability. The tablet of the present invention comprising an uncoated tablet containing 7-[4-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)butoxy]-1H-quinolin-2-one or a salt thereof as an active ingredient, excipients such as lactose, corn starch, and microcrystalline cellulose; disintegrants such as low-substituted hydroxypropylcellulose, croscarmellose sodium, and sodium carboxymethyl starch; binders such as hydroxypropylcellulose; lubricants such as stearate;


Patent
Otsuka Pharmaceutical Factory Inc. | Date: 2017-02-16

The present invention provides a pyrrolidine compound of General Formula (1) or a salt thereof, wherein R^(101 )and R^(102 )are each independently a phenyl group or a pyridyl group, the phenyl group or the pyridyl group may have one or more substituents selected from halogen atoms and lower alkyl groups optionally substituted with one or more halogen atoms, etc. The pyrrolidine compound or a salt thereof of the present invention is usable to produce a pharmaceutical preparation having a wider therapeutic spectrum and being capable of exhibiting sufficient therapeutic effects after short-term administration.


Patent
Otsuka Pharmaceutical Factory Inc. | Date: 2017-09-20

An object of the present invention is to provide a device for assisting determination of pathology by displaying a list containing gene mutation information extracted from sequence data having gene sequence of a test subject, as well as various items of medical information regarding the gene mutation stored in public databases or the like, thereby specifying a pathogenic gene mutation of a test subject. The device for assisting determination of pathology of a polycystic kidney disease according to the present invention comprises an extraction means 21 for extracting gene mutation information in a region related to polycystic kidney disease using sequence data showing gene sequences of a test subject; an acquisition means 22 for acquiring, using the extracted gene mutation information, medical information corresponding to the extracted gene mutation from a plurality of databases in which gene mutation and medical information are associated with each other; and a list display means 23 for displaying a list containing the extracted gene mutation information and the obtained medical information.

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