Otsuka AgriTechno Co.

Naruto, Japan

Otsuka AgriTechno Co.

Naruto, Japan
SEARCH FILTERS
Time filter
Source Type

Tsugehara T.,Kobe University | Imai T.,Otsuka AgriTechno Co. | Takeda M.,Kobe University
Comparative Biochemistry and Physiology - C Toxicology and Pharmacology | Year: 2013

Arylalkylamine N-acetyltransferase (AANAT; EC 2.3.1.87) catalyzes the N-acetylation of arylalkylamines. A cDNA encoding AANAT (ApAANAT) was cloned from Antheraea pernyi by PCR. The cDNA of 1966 bp encodes a 261 amino acid protein. The amino acid sequence was found to have a high homology with Bombyx mori AANAT (BmNAT) but had very low homology with vertebrate AANATs. Amino acid sequence analysis revealed that four insect AANATs cloned from three species including ApAANAT formed a distinct cluster from the vertebrate group. A recombinant ApAANAT protein was expressed in Sf9 cells using a baculovirus expression system, having AANAT activity. The transformed cell extract acetylated tryptamine, serotonin, dopamine, tyramine, octopamine and norepinephrine. The AANAT activity was inhibited at over 0.03 mM tryptamine. Although insect AANATs have been considered as a target of insecticide, this type of insecticide has never been developed. Screening a chemical library of Otsuka Chemical Co.; Ltd.; we found a novel compound and its derivatives that inhibited the AANAT activity of ApAANAT. This may facilitate investigation of the monoamine metabolic pathway in insects and the development of new types of insecticides and inhibitors of AANATs. © 2012 Elsevier Inc.


Takahashi N.,Otsuka AgriTechno Co. | Nakagawa H.,Otsuka AgriTechno Co. | Sasama Y.,Otsuka AgriTechno Co. | Ikemi N.,Otsuka AgriTechno Co.
Journal of Pesticide Science | Year: 2012

Cyflumetofen is a novel benzoylacetonitile acaricide developed by Otsuka AgriTechno Co., Ltd. It has excellent efficacy against a variety of mites that attack fruits, nuts, vegetables, tea, and ornamentals. In addition, cyflumetofen exhibited long persistence efficacy against mites. The new and unique chemistry of cyflumetofen provides effectiveness against mites that have developed resistance to existing acaricides. Extensive studies have shown that cyflumetofen inhibits the mitochondrial electron-transport function of complex II, which is a novel target for the mode of action among pesticides. These findings suggest that cyflumetofen could be an ideal component for integrated pest management (IPM) programs and resistant management programs because it is significantly safe for non-target organisms such as natural enemies and beneficial arthropods, and for the environment. © Pesticide Science Society of Japan.


Ohta H.,Kumamoto University | Oshiumi H.,Kumamoto University | Hayashi N.,Otsuka AgriTechno Co. | Imai T.,Otsuka AgriTechno Co. | And 3 more authors.
Bioscience, Biotechnology and Biochemistry | Year: 2012

Octopamine receptors are attractive insecticide targets. To screen compounds acting at octopamine receptors simply and rapidly, we constructed a chemiluminescent reporter gene assay system that detects secreted placental alkaline phosphatase transcriptionally regulated by the cAMP response element for a silkworm octopamine receptor. This system proved useful in high-throughput screening to develop octopamine receptor-specific insecticides.


Hayashi N.,Otsuka AgriTechno Co. | Sasama Y.,Otsuka AgriTechno Co. | Takahashi N.,Otsuka AgriTechno Co. | Ikemi N.,Otsuka AgriTechno Co.
Pest Management Science | Year: 2013

Background: Cyflumetofen is a novel acaricide developed by Otsuka AgriTechno Co., Ltd. It affects only spider mites and has no effect on insects, crustaceans or vertebrates under conditions of practical use. The mode of action of cyflumetofen, its selectivity for mites and its safety for insects and vertebrates were investigated. Results: The research showed that cyflumetofen inhibited mitochondria complex II in mites. In addition, the de-esterified form (AB-1) of cyflumetofen inhibited mitochondria complex II at extremely low concentrations. AB-1 was also detected as the main metabolite in mites. Conclusion: The mode of action of cyflumetofen is to inhibit mitochondria complex II by affecting its action site after being metabolised to AB-1. However, inhibition by cyflumetofen and AB-1 in other organisms was very weak. Selectivity for other organisms has contributed to differences in action site activities. © 2012 Society of Chemical Industry.


An object of the present invention is to provide a novel fungicide having an excellent fungicidal activity. The compound used as the fungicide of the present invention is an ethynylphenylamidine compound or a salt thereof, the compound being represented by Formula (1):^(1) and R^(2) are each hydrogen or C_(1-12) alkyl, or R^(1) and R^(2) may be bonded together to form C_(1-7) alkylene;R^(3) is hydrogen or C_(1-4) alkylthio;R^(4), R^(5), R^(6), and R^(7) are each hydrogen, halogen, etc.; andR^(8) is hydrogen, C_(1-20) alkyl, C_(3-8) cycloalkyl, C_(1-4) haloalkyl, phenyl, a heterocyclic group, or -(CH_(2))n-Si(R^(9))(R^(10))(R^(11)) wherein R^(9), R^(10), and R^(11) are each C_(1-6) alkyl, and n is an integer of 0 or 1.


An object of the present invention is to provide a novel fungicide having an excellent fungicidal activity. The compound used as the fungicide of the present invention is an ethynylphenylamidine compound or a salt thereof, the compound being represented by Formula (1): wherein R^(1 )and R^(2 )are each hydrogen or C_(1-12 )alkyl, or R^(1 )and R^(2 )may be bonded together to form C_(1-7 )alkylene;


The present invention provides an animal ectoparasite-controlling agent and a method for preventing or treating infection in animals caused by parasites by using the controlling agent. An animal ectoparasite-controlling agent exhibiting excellent insecticidal activity, and a method for preventing or treating infection in animals caused by parasites by using the controlling agent are obtained by using a compound having a pyrazole ring at the 4-position of the piperidine ring as an active ingredient.


An object of the present invention is to provide a novel fungicide having an excellent fungicidal activity. The compound used as the fungicide of the present invention is an ethynylphenylamidine compound or a salt thereof, the compound being represented by Formula (1): wherein R^(1 )and R^(2 )are each hydrogen or C_(1-12 )alkyl, or R^(1 )and R^(2 )may be bonded together to form C_(1-7 )alkylene;

Loading Otsuka AgriTechno Co. collaborators
Loading Otsuka AgriTechno Co. collaborators