Medicine, United Kingdom
Medicine, United Kingdom

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Blake G.M.,Osteoporosis Research Unit | Siddique M.,King's College London | Frost M.L.,Osteoporosis Research Unit | Moore A.E.B.,Osteoporosis Research Unit | Fogelman I.,King's College London
Current Osteoporosis Reports | Year: 2014

The functional imaging technique of dynamic fluorine-18 labeled sodium fluoride positron emission tomography (18F-NaF PET) allows the quantitative assessment of regional bone formation bymeasuring the plasma clearance of fluoride to bone at any site in the skeleton.18F-NaF PET provides a novel and noninvasive method of studying sitespecific bone formation at the hip and spine, as well as areas of pure cortical or trabecular bone.The technique complements conventional measurements of bone turnover using biochemical markers and bone biopsy as a tool to investigate new treatments for osteoporosis, and holds promise of a future role as an early biomarker of treatment efficacy in clinical trials.This article reviews methods of acquiring and analyzing 18FNaF PET scan data, and outlines a simplified approach that uses 5-minute static PET scan images combined with venous blood samples to estimate 18F-NaF plasma clearance at multiple sites in the skeleton with a single injection of tracer. © Springer Science+Business Media New York 2014.


VanDenKerkhof E.G.,Queen's University | Macdonald H.M.,Osteoporosis Research Unit | Jones G.T.,Aberdeen Group | Power C.,University College London | And 2 more authors.
Pain Research and Management | Year: 2011

OBJECTIVES: To examine the relationship between diet and lifestyle, and chronic widespread pain (CWP). If persons with CWP have dietary and lifestyle habits consistent with an increased risk of cancer or cardiovascular disease, it may partially explain evidence in the literature suggesting an association between CWP and these diseases. METHODS: The 1958 British Birth Cohort Study comprises individuals born in England, Scotland and Wales in the United Kingdom during one week in March 1958. At 45 years of age, pain was recorded using a self-completion questionnaire. CWP was classified using the American College of Rheumatology definition for fibromyalgia. Data were collected on diet and lifestyle at 33 and 42 years of age. RESULTS: A total of 8572 participants provided pain data at 45 years of age, of whom 12% reported CWP. Women with CWP, compared with those without, reported an unhealthy diet (ie, fruit/vegetable consumption less than once per week [OR 2.0; 95% CI 1.3 to 3.1], and fatty food [OR 1.7; 95% CI 1.1 to 2.7] and chips (french fries) [OR 1.5; 95% CI 1.0 to 2.4] at least once per day) that may have predisposed them to other chronic diseases such as cancer and cardiovascular disease. Women with CWP were also more likely to be unemployed (adjusted OR 1.4; 95% CI 1.1 to 1.8), to have had high physical exertion at work (adjusted OR 1.6; 95% CI 1.2 to 2.2) and elevated body mass index (overweight - adjusted OR 1.5, 95% CI 1.2 to 1.9; obese - adjusted OR 1.8, 95% CI 1.3 to 2.5). Similar relationships between lifestyle (but not diet) and the risk of CWP were identified in men. CONCLUSIONS: The findings for smoking, body mass index and (for women) diet offer support for the hypothesis that lifestyle factors may partially explain the association between CWP and cancer or cardiovascular disease. Prospective studies are necessary to confirm this relationship. ©2011 Pulsus Group Inc. All rights reserved.

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