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Bozzetti F.,University of Milan | Mariani L.,Unit of Clinical Epidemiology and trial Organization | Lo Vullo S.,Unit of Clinical Epidemiology and trial Organization | Biffi R.,Istituto Europeo di Oncologia | And 16 more authors.
Supportive Care in Cancer | Year: 2012

Purpose There is little information about the nutritional status of cancer outpatients because the practice of nutritional screening is rarely performed. This study aims to define the pattern of scores of nutritional risk in 1, 453 outpatients and factors associated with a high nutrition risk score, to facilitate the identification of such patients by the oncologists. Methods We prospectively screened the nutritional status of cancer outpatients according to the NRS-2002 score which combines indicators of malnutrition and of severity of the disease (1-3 points, respectively). A score ≥3 indicates "nutritional risk". The association of the nutritional scores with some patient/tumour/therapy-related variables was investigated through univariable and multivariable linear regression models. Results Thirty-two percent of outpatients were at nutritional risk. Primary tumour site, Eastern Cooperative Oncology Group score and presence of anorexia or fatigue were significantly associated with the nutrition risk score. Depending on the combination of these variables, it was possible to estimate different probabilities of nutritional risk. Conclusions The frequency of a relevant nutritional risk was higher than expected considering the favourably selected population. The nutritional risk was associated with common clinical variables which are usually recorded in the charts and could easily alert the oncologist on the need of a further nutritional assessment or a nutritional support. © 2011 Springer-Verlag. Source


Cerocchi I.,University of Rome Tor Vergata | Ghera S.,Ospedale San Pietro Fatebenefratelli | Gasbarra E.,University of Rome Tor Vergata | Scialdoni A.,University of Rome Tor Vergata | Tarantino U.,University of Rome Tor Vergata
Aging Clinical and Experimental Research | Year: 2013

The clinical management of fragility fracture is simple but complex at the same time. Patients are different from one another, and advancing age increases the prevalence of comorbidities and conditions that can impair bone quality and healing, while increasing the risk of falls and fractures. Keeping in mind some principles and key points can help identify patients at risk, thus following an ideal path for the identification, treatment and prevention of fragility fractures. © 2013 Springer International Publishing Switzerland. Source


Cerocchi I.,University of Rome Tor Vergata | Ghera S.,Ospedale San Pietro Fatebenefratelli | Gasbarra E.,University of Rome Tor Vergata | Feola M.,University of Rome Tor Vergata | Tarantino U.,University of Rome Tor Vergata
Aging Clinical and Experimental Research | Year: 2013

Wrist fracture is the most common fragility fracture in perimenopausal and young postmenopausal women in USA and Northern Europe. Recent studies based on high-resolution imaging have shown microarchitectural deterioration of trabecular bone even in premenopausal women presenting with a wrist fracture. These fractures increase the risk of subsequent fractures, especially in the first 7 years. So, wrist fracture female patients must be appropriately screened and treated for osteoporosis in order to preserve bone quality and prevent future, more severe, fractures. © 2013 Springer International Publishing Switzerland. Source


Migliore A.,UOS of Rheumatology | Massafra U.,UOS of Rheumatology | Bizzi E.,UOS of Rheumatology | Tormenta S.,Ospedale San Pietro Fatebenefratelli | And 2 more authors.
International Journal of Immunopathology and Pharmacology | Year: 2014

The intra-articular administration of hyaluronic acid (HA) in hip osteoarthritis (OA) has been recently increased following the use of ultrasound guidance to perform an accurate delivery of the injected product. Viscosupplementation in hip OA seems to show similar results to those obtained by viscosupplementation in knee OA. However, an unmet need is the duration of symptomatic relief, therefore several new products are proposed to prolong and increase symptomatic effects. Among these, an innovative viscosupplement has been produced from high a concentration of HA combined with a high concentration of sorbitol as a free radical scavenger. The aim of this study is to evaluate the mid-term pain-relief effect of an ultrasound-guided injection of SynolisV-A (ANTI-OX-VS) in patients suffering from symptomatic hip osteoarthritis. Lequesne index, Health Assessment Questionnaire (HAQ), pain reduction, Global Patient Assessment (GPA), Global Medical Assessment (GMA) and reduction in monthly analgesic consumption were assessed during the 12-month follow-up after the injection. A total of 20 patients were enrolled in the study and received one IA US-guided injection of two syringes of ANTI-OX-VS into the target hip. Eleven drop-out patients were registered, of whom 2 were for loss of efficacy at 6 months, 1 for loss of efficacy at 9 months and 8 patients for severe comorbilities. Mean scores of all clinical parameters evaluated at each control visit were significantly different when compared with baseline mean value. No systemic adverse events were observed. Even though the sample size of this study is limited, the results suggest a durable good efficacy of a 4-ml single injection of ANTI-OX-VS in hip OA, at least for the patients who completed the study. A larger number of patients and an RCT are needed to confirm these data, investigating also the predictive factors of clinical response to ANTI-OX-VS. Copyright © by BIOLIFE, s.a.s. Source


Bardocci A.,Ospedale San Pietro Fatebenefratelli | Abad J.C.,Clinica Clofan | Tamburrelli C.,University Cattolica ore | Lofoco G.,Ospedale San Pietro Fatebenefratelli | And 2 more authors.
Seminars in Ophthalmology | Year: 2012

Purpose: We describe a case of early onset keratectasia after photorefractive keratectomy (PRK) in a patient with Vertical D topographic pattern in one eye and suspected keratoconus in the other eye. Methods: A 31-year-old woman underwent bilateral PRK: attempted correction was 8.002.00 × 30°in her right eye (RE) and 4.501.50 × 150°tabo in her left eye (LE). Preoperative corneal thickness was 512 m in the RE and 520 m in the LE. Preoperative topography showed an asymmetric bow-tie pattern and skewed axis in RE and a Vertical D pattern in LE. Intended maximum ablation was 91 m in RE and 66 m in LE. Results: Three months postoperatively the patient showed early topographic signs of bilateral keratectasia, evolved to manifest keratectasia after six years. Conclusions: Although rare after PRK, keratectasia may occur even following moderate (66 m) surface ablation in eyes with Vertical D topographic pattern in one eye and controlateral suspected keratoconus. © 2012 Informa Healthcare USA, Inc. Source

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