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Sant'Ambrogio di Torino, Italy

Berardelli R.,Ospedale S. Giovanni Battista Molinette | Gianotti L.,S. Croce and Carle Hospital | Karamouzis I.,Ospedale S. Giovanni Battista Molinette | Picu A.,Ospedale S. Giovanni Battista Molinette | And 6 more authors.
Gynecological Endocrinology | Year: 2011

Background.Gonadotropin Releasing Hormone (GnRH) antagonists (GnRHa) suppress gonadotropin and sex-steroid secretion. In normal women, acute GnRHa administration induces inhibitory effect on pituitary-gonadal axis, followed by Luteinizing Hormone (LH) rebound. Functional hypothalamic amenorrhea (HA) is characterised by impaired gonadotropin secretion and hypogonadism secondary to blunted GnRH pulsatility. Methods.We studied the effects of a GnRHa, cetrorelix (CTX 3.0mg), in six women with HA (age 30.7±3.2 years; BMI 21.5plusmn;1.7 kg/m 2) and six control subjects (CS, 28.2 ± 0.6 years; 22.6± 0.9 kg/m 2) on LH, Follicle-Stimulating Hormone (FSH) and oestradiol levels over 4h (08.0012.00 am) before, +24h and +96h after CTX; LH, FSH, and oestradiol were also evaluated at +6, +8, +12, +48, +72h after CTX. Results.CS: CTX reduced (p<0.05) LH, FSH, and oestradiol (nadir at +12h, +24h, and +24h); LH rebounded at +96h, FSH and oestradiol recovered at +48h and +72h. The 4-h evaluation showed LH and FSH reduction (p < 0.05) at +24h, with LH rebound at +96h. HA: CTX reduced (p < 0.05) LH, FSH, and oestradiol, (nadir at +24h, +48h, and +48h, recovery at +48h, +72h, and +96h). The 4-h evaluation showed gonadotropin reduction (p<0.05) 24h after CTX, without any rebound effect. Conclusions.One single CTX dose still modulates gonadotropin secretion in HA. Its 'paradoxical' stimulatory effect on gonadotropins needs to be verified after prolonged administration. © 2011 Informa UK, Ltd.

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