Hyderabad, India
Hyderabad, India

The Osmania University ఉస్మానియా విశ్వవిద్యాలయము جامعہ عثمانیہ is a public state university located in Hyderabad, India, and founded in 1918 with the help of chief Architect of Mahbub Ali Khan - Nawab Sarwar Jung It was established and named after the last Nizam of Hyderabad, Mir Osman Ali Khan. It is the first Indian university to have Urdu as a medium of instruction.In 2012, the university was placed sixth among the Nation's Premier Universities in Humanities, science and Commerce stream, which bagged the 'University with Potential for Excellence' status. The Main Campus is ranked tenth among the State Universities, as published by India Today. As of 2012, the university hosts 3,700 international students from more than 80 nations.The OU is one of the largest university systems in the subcontinent with over 300,000 students on its campuses and affiliated colleges. It is particularly known for its faculty of Engineering and Technology, Law, Arts, science, Commerce and Management departments. Osmania Medical College was once a part of the university. However, it is now under the supervision of NTR University of Health science.The university is a chief intellectual centre in Hyderabad, and its alumni and faculty members include many distinguished individuals, including former Prime Minister of India P. V. Narasimha Rao.The state government has appointed Prof S Satyanarayana as vice chancellor of the University.The University is accredited by the NAAC with an 'A' Grade and conferred with the status of 'University with Potential for Excellence' by the UGC, New Delhi. Wikipedia.

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Ulaganathan K.,Osmania University
Renewable and Sustainable Energy Reviews | Year: 2017

Lignocellulosic biomass, though available in massive volumes, is not used for production of bioethanol due to existence of several barriers which escalate the cost of production. Microorganisms possess different proteins associated with different stages of lignocellulosic bioethanol production. Though a large number of such proteins have been identified, their specificities and expression levels are not suitable for lignocellulosic bioethanol production. Additionally, the host organism used for bioethanol production may not be tolerant to temperature, pH and ethanol stresses. Hence, the host organisms and the proteins used for bioethanol production needs to be engineered to suit the conditions for ethanol production. Engineering the host strain and altering specificities of proteins employed for bioethanol production can be achieved by genetic engineering techniques, where the gene of interest is isolated first, manipulated in vitro and introduced back into the host organism. Recently, a number of precision genome engineering techniques have been developed which facilitate modification of genes / genomic regions directly in the organism of interest without the need for isolating the genes/genomic regions. These techniques include (a). The bacterial immunity based CRISPR/Cas system, (b). Xanthomonas transcription-activator-like effector nuclease based TALEN system, (c). Zinc finger domain based ZFN system, (d). Long region recognizing-nuclease based meganuclease system and (e). Oligonucleotide based YOGE system. Protein engineering studies and whole genome sequencing of bioethanol producing strains have shown that alteration of one or more nucleotides can bring out large changes that facilitate increased production of cellulosic bioethanol. These precision engineering techniques can supplement genetic engineering to bring out alteration in specificities of enzymes and change the host's tolerance to various stress levels by specific alteration of genomic regions. In this review, various methods of genome engineering available and their possible application for breaking barriers in lignocellulosic bioethanol production are discussed. © 2017 Elsevier Ltd


Basude M.,Osmania University
Journal of Chemical and Pharmaceutical Research | Year: 2011

Ammoxidation of methyl N-heteroaromatic compounds was investigated on non-conventional vanadium phosphorus oxides of different origin and supported vanadium phosphorus oxide catalyst under atmospheric pressure at 400 0C. Conventional V2O5-MoO3/Al2O3 catalyst was studied for comparison under similar conditions. The catalysts were characterized by means of X-ray diffraction, electron spin resonance, infrared, scanning electron microscopy, differential thermal analysis, ammonia chemisorption and BET surface area methods. The catalytic activity is correlated well with the physicochemical characteristics of the catalyst. Higher activity for SiO2 supported VPO catalyst compared to conventional catalyst V2O5-MoO3/Al2O3 and vanadium phosphorus oxides of different origin can be attributed to high active surface area, lower oxidation state of vanadium and higher surface acidity. A redox cycle between (V 4+) and (V 5+) species appears to be responsible for the ammoxidation activity of VPO catalyst.


Raghava K.M.,Osmania University | Lakshmi P.K.,Osmania University
Brazilian Journal of Pharmaceutical Sciences | Year: 2012

P-glycoprotein (P-gp), a transmembrane permeability glycoprotein, is a member of ATP binding cassette (ABC) super family that functions specifically as a carrier mediated primary active efflux transporter. It is widely distributed throughout the body and has a diverse range of substrates. Several vital therapeutic agents are substrates to P-gp and their bioavailability is lowered or a resistance is induced because of the protein efflux. Hence P-gp inhibitors were explored for overcoming multidrug resistance and poor bioavailability problems of the therapeutic P-gp substrates. The sensitivity of drug moieties to P-gp and vice versa can be established by various experimental models in silico, in vitro and in vivo. Ever since the discovery of P-gp, the research plethora identified several chemical structures as P-gp inhibitors. The aim of this review was to emphasize on the discovery and development of newer, inert, non-toxic, and more efficient, specifically targeting P-gp inhibitors, like those among the natural herb extracts, pharmaceutical excipients and formulations, and other rational drug moieties. The applications of cellular and molecular biology knowledge, in silico designed structural databases, molecular modeling studies and quantitative structure-activity relationship (QSAR) analyses in the development of novel rational P-gp inhibitors have also been mentioned.


Srinivas M.,Osmania University
Materials Today: Proceedings | Year: 2016

Phosphor Ca3La2(BO3)4 materials doped with terbium ions were prepared by high temperature solid state reaction method. The structural properties, surface morphology and elemental analysis of terbium doped calcium lanthanum borate phosphors are investigated via X-ray diffraction (XRD), scanning electron microscopy (SEM) and energy dispersive X-ray analysis (EDAX). The main diffraction peaks of the orthorhombic structure observed in all the samples. Strong photoluminescence (PL) spectrum was obtained at 543 nm under UV excitation. Emission spectra can be assigned to the emission lines of terbium activators corresponding to 422, 490, 543, 588 and 622 nm attributed to the 5D4→7FJ (J = 2, 3, 4, 5, 6) transitions of Tb3+ ions from a spectral range of 400-750 nm (whole visible spectral region) observed in the PL emission spectrum. PL peak intensity was found to increase with increase in the dopant concentration. These phosphors may provide a new kind of luminescent material for light emitting diodes under UV excitation. © 2016 Elsevier Ltd. All rights reserved.


In this analysis, the boundary layer flow and heat transfer over a permeable stretching sheet due to a nanofluid with the effects of magnetic field, slip boundary condition and thermal radiation have been investigated. The transport equations used in the analysis took into account the effect of Brownian motion and thermophoresis parameters. The solution for the velocity, temperature and nanoparticle concentration depends on parameters viz. thermal radiation parameter R, Prandtl number Pr, Lewis number Le, Brownian motion parameter Nb, thermophoresis parameter Nt, Eckert number Ec, magnetic parameter M and slip parameters. Similarity transformation is used to convert the governing non-linear boundary-layer equations into coupled higher order non-linear ordinary differential equations. These equations are numerically solved using fourth order Runge-Kutta method along with shooting technique. An analysis has been carried out to elucidate the effects of governing parameters corresponding to various physical conditions. Numerical results are obtained for distributions of velocity, temperature and concentration, as well as, for the skin friction, local Nusselt number and local Sherwood number for several values of governing parameters. The results indicate that the local Nusselt number decreases with an increase in both Brownian motion parameter Nb and thermophoresis parameter Nt. However, the local Sherwood number increases with an increase in both thermophoresis parameter Nt and Lewis number Le, but it decreases as the values of Nb increase. Besides, it was found that the surface temperature of a sheet increases with an increase in the Eckert number Ec. A comparison with previous studies available in the literature has been done and we found an excellent agreement with it. © 2013 Elsevier Ltd.


Rao S.L.N.,Osmania University
Food and Chemical Toxicology | Year: 2011

The low incidence of neurolathyrism, its absence in several communities traditionally consuming Lathyrus sativus and the likely benefits of its inclusion as part of a normal diet are reviewed. The metabolism/detoxification of ODAP which is unique to humans may be a crucial factor in this regard. The presence of homoarginine in the pulse which has received scant attention in the past could make this an invaluable pulse since it could contribute to a sustained generation of NO. NO is well recognized for its role in cardiovascular physiology and general well-being and thus a daily dietary intake of homoarginine through small quantities of L. sativus may be of advantage and deserves to be exploited. The detoxification of ODAP in humans could spotlight the pulse further for its non-neurotoxic attributes. Activation of PKC by ODAP adds a new dimension to explore its possible therapeutic potentials in areas such as Alzheimer's disease, hypoxia, and long term potentiation. These novel approaches to both ODAP and homoarginine might entirely change our perception of this poor man's pulse. © 2010 Elsevier Ltd.


Ganesh A.,Osmania University
International Journal of Pharma and Bio Sciences | Year: 2013

The review of the literature shows that the pyrazoline derivatives is quite stable and has inspired chemists, to utilize pyrazoline fragment in bioactive moieties, to synthesize new pyrazoline derivatives. The past studies of pyrazoline derivative revealed that they are useful in pharmaceutical and agrochemical research. Pyrazoline derivatives display various biological activities such as antitumor, antitubercular, antimicrobial, antibacterial, anti-inflammatory and antioxidant etc.


Narra M.R.,Osmania University
Archives of Environmental Contamination and Toxicology | Year: 2014

Chlorpyrifos (CPF), an organophosphate widely applied in agriculture and aquaculture, induces oxidative stress due to free-radical generation and changes in the antioxidant defense system. The present study investigated the short-term effect of CPF exposure on the oxidative and antioxidant systems and their recovery responses in metabolically active tissues (gills, hepatopancreas [HP], and leg muscle) of freshwater crab Barytelphusa guerini. Crabs were exposed to a sublethal concentration of CPF (0.07 mg L-1) for a total of 8 days (at intervals of 1, 2, 4, and 8 days) in clean water. The following oxidative stress markers were measured: acetylcholinesterase (AChE), butylcholinesterase (BChE), and ATPase; antioxidants i.e., superoxide dismutase (SOD), catalase, and glutathione reductase (GR), lipid peroxidation (LPO), conjugating enzyme glutathione S-transferase (GST), glutathione peroxidase (GPx), and lipid content. CPF exposure led to a significant decrease in the activity of oxidative stress markers as follows: AChE (84%), BChE (46%), and gills Na+/K+ ATPase (62%). At the end of the recovery period, enzyme levels were recovered except in leg muscle. Total lipids and SOD decreased; CAT and LPO levels increased; and GPx, GR, and GST showed tissue-specific activities. Maximum recovery was observed in GPx followed by GR in HP tissue of crab. Nevertheless, these responses apparently grant successful adaptation for survival in a pesticide-extreme environment. © Springer Science+Business Media 2014.


Statins reduce the risk of cardiovascular events by lowering the blood cholesterol. Many genes involved in the pharmacodynamic pathway of statins have been part of pharmacogenetic research in patients with hypercholesterolemia, with an emphasis on genes involved in the cholesterol pathway. The present study was carried out with an aim to evaluate the association between the genetic variants of lipoprotein lipase gene [HindIII (+/+)/HindIII (-/-)], multiple drug resistance gene (C3435T) and endothelial nitric oxide synthase gene (4a/4b) with clinical outcome including an increased risk of recurrent stroke or death in ischemic stroke patients on atorvastatin therapy. 525 stroke patients and 500 healthy controls were involved in the study. Follow-up telephone interviews were conducted with patients post-event to determine stroke outcome. Blood samples were collected and genotypes determined by polymerase chain reaction-restriction digestion technique. A significant association of MDR1 and LPL gene variants with bad outcome in stroke patients on atorvastatin therapy was found. However, there was no significant association of 27 bp VNTR polymorphism of eNOS gene with outcome. MDR analysis was carried out to analyze gene-gene interaction involving these gene variants contributing to clinical outcome of patients on stratin therapy but no significant interaction between these variants was observed. In conclusion the individuals with HindIII (-/-) genotype of LPL and CC genotype of MDR1 gene would benefit more from atorvastatin therapy. © 2012 Springer-Verlag.


Patent
Osmania University | Date: 2010-11-25

The present disclosure relates to identifying and characterizing polynucleotide sequences encoding proteins more particularly from Cajanus cajan, that are associated with abiotic stress responses in plants. In particular, the present disclosure provides a method for producing abiotic stress tolerant transgenic plant, more specifically salt, drought, heat and/or cold stress tolerant plant.

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