Hellings P.W.,University Hospitals Leuven |
Akdis C.,Swiss Institute of Allergy |
Bachert C.,Ghent University |
Cingi C.,Osmangazi University |
And 13 more authors.
Allergy: European Journal of Allergy and Clinical Immunology | Year: 2013
State-of-the-art documents like ARIA and EPOS provide clinicians with evidence-based treatment algorithms for allergic rhinitis (AR) and chronic rhinosinusitis (CRS), respectively. The currently available medications can alleviate symptoms associated with AR and RS. In real life, a significant percentage of patients with AR and CRS continue to experience bothersome symptoms despite adequate treatment. This group with so-called severe chronic upper airway disease (SCUAD) represents a therapeutic challenge. The concept of control of disease has only recently been introduced in the field of AR and CRS. In case of poor control of symptoms despite guideline-directed pharmacotherapy, one needs to consider the presence of SCUAD but also treatment-related, diagnosis-related and/or patient-related factors. Treatment-related issues of uncontrolled upper airway disease are linked with the correct choice of treatment and route of administration, symptom-oriented treatment and the evaluation of the need for immunotherapy in allergic patients. The diagnosis of AR and CRS should be reconsidered in case of uncontrolled disease, excluding concomitant anatomic nasal deformities, global airway dysfunction and systemic diseases. Patient-related issues responsible for the lack of control in chronic upper airway inflammation are often but not always linked with adherence to the prescribed medication and education. This review is an initiative taken by the ENT section of the EAACI in conjunction with ARIA and EPOS experts who felt the need to provide a comprehensive overview of the current state of the art of control in upper airway inflammation and stressing the unmet needs in this domain. © 2012 John Wiley & Sons A/S.
Kocman E.A.,Osmangazi University |
Ozatik O.,Osmangazi University |
Sahin A.,Eskiehir Osmangazi University |
Guney T.,Osmangazi University |
And 4 more authors.
Journal of Surgical Research | Year: 2015
Results Tissue biochemical markers were improved in nearly all the IPC groups compared with IsO and I/R groups (P < 0.05). Similarly, the histologic damage scores were decreased in all the IPC groups (P < 0.05). The lowest damage score was in the e-RIPC group followed by the l-RIPC, e-IPC, and l-IPC groups, respectively. The apoptosis scores were significantly high in the I/R group compared with the e-RIPC and l-RIPC groups (P < 0.05). Although apoptosis scores of the e-IPC and l-IPC groups were lower than the I/R group, this finding was not statistically significant (P > 0.05).Conclusions All IPC protocols were effective in reducing I/R injury. Among these protocols, e-RIPC achieved most protection.Background Ischemic preconditioning (IPC) is described as brief ischemia-reperfusion (I/R) cycles to induce tolerance to subsequent in response to longer I/R insults. Various IPC protocols can be performed in four combinations as follows: at early or late phases and on local or distant organs. Although many experimental studies have been performed on IPC, no consensus has been established on which IPC protocol is most effective. The aims of the present study were as follows: (1) to compare the variables of preconditioning in different combinations (in early versus late phases; local versus remote organ implementations) and (2) to determine the most therapeutic IPC protocol(s).Materials and methods A subtotal hind limb amputation model with clamping an intact femoral pedicle was used for I/R injury. IPC was induced using hind limb tourniquet with 3 × 10 min I/R cycles before longer I/R insult. Forty-nine rats were divided into seven groups (n = 7), sham, IsO (ischemia only), I/R, early ischemic preconditioning (e-IPC), late ischemic preconditioning (l-IPC), early remote ischemic preconditioning (e-RIPC), and l-RIPC (late-remote) groups, respectively. In the sham group, pedicle occlusion was not performed. Six hours ischemia was challenged in the IsO group. Three hours ischemia followed by 3 h reperfusion was performed in the I/R group. The e-IPC group was immediately preconditioned, whereas the l-IPC group was preconditioned 24 h before I/R injury on the same hind limb. In the e-RIPC and l-RIPC groups, the same protocols were performed on the contralateral hind limb. At the end of the experiments, skeletal muscle tissue samples were obtained for biochemical analysis (Malondialdehyde [MDA], catalase, myeloperoxidase [MPO], and nitric oxide end products [NOx]), light microscopy, and caspase-3 immunohistochemistry for determination of apoptosis. © 2015 Elsevier Inc. All rights reserved.
Bayrakceken M.K.,Turkish Air force Academy |
Yalcin M.K.,Technical University of Istanbul |
Arisoy A.,Turkish Air force Academy |
Karamancioglu A.,Osmangazi University
2011 IEEE International Conference on Mechatronics, ICM 2011 - Proceedings | Year: 2011
In this paper, we describe a dSpace ds1103 based HIL (Hardware-In-The-Loop) test platform, a dynamic model derived using Lagrangian Mechanics and a PD attitude control algorithm for a quadrotor mini UAV with experimental results. The platform is mainly intended for developing different control algorithms, fine tuning control parameters in real-time, monitoring and recording all platform data for post-processing. Additionally, platform houses a modular custom built 6 DOF IMU which provides a real-time development environment for filters or data fusion algorithms to optimize navigation solution. The electrical and functional architecture, materials chosen for building mechanical structure, all devices including brushless motors, motor drive units, IMUs are explained in detail with experiences gained during manufacturing process. Attitude control up to 20 degrees for pitch and roll, 720 degrees (two turns) for yaw and limited positional control in only z-axis (a few centimeters) for demonstration of hover is available in test platform. A detailed dynamic model which is used by several authors in literature and a simplified version for Simulink modeling is given. In the last part, the proposed classical PD control scheme and the determination of control parameters are explained. © 2011 IEEE.
Yildiz M.K.,Haydarpasa N Training And Research Hospital |
Okan I.,Osmangazi University |
Dursun N.,Istanbul Training and Research Hospital |
Bas G.,Istanbul Training and Research Hospital |
And 4 more authors.
International Journal of Clinical and Experimental Medicine | Year: 2014
Aim: Formation of adhesions in the abdominal region appearing after abdominal pelvic surgery lead to infertility, chronic pelvic pain, intestinal obstructions, difficulty and morbidity at the following operations, and increased morbidity. The aim of our study is to examine the effectiveness of orally administered simvastatin on preventing the postoperative adhesion. Materials and methods: 20 male Wistar Albino rats weighing 230-250 gr were used. The rats were housed for 12 hours day and 12 hours night cycles in cages and were divided into two groups, namely study and control group. Microscopic evaluation of adhesion was assessed under 5 main topics which are the signs of inflammatory response; inflammation, activation, fibroblast activity, vascularity, presence of giant cell. Activation was scored as follows: (0) no activation, (1) while activation was accepted as present the score for other parameters was evaluated between 0 to 3 according to the increased severity. After evaluating all topics separately, the average of all scores has been assessed in both groups. Results: As a result of the macroscopic evaluation of postoperative intra-abdominal adhesions, the percentage of adhesion in simvastatin applied group was found to be 0.8 ± 0.17. This value was calculated as 0.6 ± 0.2 in the control group. Regarding the severity of adhesion, while in the simvastatin applied group the value was found to be 9.1 ± 4, in the control group it was 6.8 ± 3. The general adhesion score was found to be 7.7 ± 4.2 in simvastatin applied group and 5.1 ± 3.7 in control group. Conclusion: In this experimental study it was showed that orally administered simvastatin has no significant effect on preventing formation of postoperative adhesions.
Kaya M.,Osmangazi University |
Kursunoglu S.,Osmangazi University
IMPC 2014 - 27th International Mineral Processing Congress | Year: 2014
Energy is the major concern for society. It is expected that developing country economies and populations will grow and consume more energy. Interest in nuclear power is rising, while the world looks for non-depletable energy source that will not contribute to global warming. However, it still has concerns of nuclear proliferation, radioactive waste and safety. It is necessary to overcome these concerns if nuclear energy is expanded to developing countries. Thorium (Th) utilization as nuclear fuel will be an opening key of these difficulties because Th produces less Plutonium (Pu) and less radioactive waste with enhanced safety. Research into the use of Th as a nuclear fuel has been taking place over forty years, through with much less intensity than that for uranium (U) or U-Pu fuels. Nuclear industry is currently using only 0.7% of the available energy from mined U. With huge resources of Th and relatively little U, Turkey has made utilization of Th for large-scale energy production a major goal in its nuclear power programme. Thorium fuel is plentiful and inexpensive. Energy is major concern for developing Turkish society. Turkey, today exports more than 70% of its energy as fossil fuels. In the last 50 years, Turks are skeptical, anxious and indecisive about having nuclear energy for electricity production. In the last 10 years, Thorium is brought into Turkish government's attention and national discussion as a new, safe, clean, affordable, CO2-free, alternative, strategic and domestic nuclear energy fuel. Turkey recently contacted four VVER-1200 type Russian Nuclear Power Reactors using U as a fuel in Akkuyu (Rosatom) and another four units will be established in Sinop in the next decade by Japan (Mitsubishi-Westinghouse). Turkish nuclear programme must envisage use of domestic Th as a fertile material. This paper briefly reviews the developments of Th-fuel cycle for nuclear energy from global and Turkish perspectives. Previous Th reserve development and recovery studies from Turkish bastnasite ore are summarized in this paper.
Bulur I.,Osmangazi University |
Keseroglu H.O.,Diskapi Yildirim Beyazit Education and Research Hospital |
Saracoglu Z.N.,Osmangazi University |
Gonul M.,Diskapi Yildirim Beyazit Education and Research Hospital
Journal of Dermatological Case Reports | Year: 2015
Background: Symmetrical drug related intertriginous and flexural exanthema (SDRIFE or Baboon syndrome) is a symmetrical contact dermatitis on inverse regions of the body. The disorder is easily differentiated from other drug eruptions by its typical appearance and lack of other concurrent findings. Observation: A 50-year-old male patient presented to our clinic complaining of a rash that had developed two days after the tenth infliximab infusion for psoriasis and reoccurred after consecutive infusions. The physical examination revealed a bilateral intergluteal, inguinal, abdominal, axillary, antecubital and neck region macular erythematous rash. There were no other systemic findings. The laboratory values were within normal range. The patient was diagnosed with symmetrical drug-related intertriginous and flexural exanthema associated with infliximab treatment based on dermatological findings, histopathology and the results of the provocation test. The lesions resolved permanently after the patient was swiched from infliximab to adalimumab. Conclusion: Various cutaneous adverse events of anti-tumor necrosis factor alpha treatment have already been reported. The increased use of these agents can lead to a wider variety of drug-induced skin lesions, such as the reported Baboon syndrome. © 2015, Specjalisci Dermatolodzy. All rights reserved.
Dlndls G.,Osmangazi University |
Karamanclolu A.,Osmangazi University
Transactions of the Institute of Measurement and Control | Year: 2016
A novel swing-up algorithm for an inverted pendulum under a restricted cart track length is introduced. The algorithm achieves the swing-up task by means of a control law that uses a finite input set. The algorithm neither knows nor uses values of cart and pendulum masses, or pendulum length. In the swing-up process, it self-learns a weight that is used in normalizing the energy injected to the pendulum. This weight makes it possible for the algorithm to determine the number of sampling periods needed to reach the upright equilibrium state. Also, by predicting the multi-step ahead cart position, it gives rise to a control law that keeps the cart within the track and makes the pendulum reach the neighbourhood of the upright equilibrium state in a smooth manner. The validity and robustness of the swing-up algorithm are verified through laboratory experiments. © The Author(s) 2015.
Gokce E.,Gaziosmanpaşa University |
Beyhan M.,Zile State Hospital |
Acu B.,Osmangazi University |
Deniz Demir H.,Gaziosmanpaşa University
Clinical Imaging | Year: 2014
In this study, radiological findings of acquired dacryocystocele are presented. A total of 13 dacryocystoceles including bilateral in two of the patients, in four patients on the left and in five patients on the right, were determined. Six of the patients had dacryocystocele infection. Average density of the non-infected dacryocystoceles was 11.8±7.8 Haunsfield units (HU), while the median density value of infected ones was 35.0 HU. There was expansion on unilateral nasolacrimal duct in four patients. Acquired dacryocystoceles are rare masses in medial canthal area, and their radiological imaging findings may vary based on etiological factors and presence of infections. © 2014 Elsevier Inc.
PubMed | Suleyman Demirel University of Turkey, Eskisehir State Hospital and Osmangazi University
Type: Journal Article | Journal: Journal of physical therapy science | Year: 2016
[Purpose] The aim of this study was to assess the relationship between atherosclerosis and knee osteoarthritis grade in women as assessed by both ultrasonography and radiography. [Subjects and Methods] Seventy women diagnosed with knee osteoarthritis were classified into two groups according to cartilage grading/radiographic grading. Patients with Kellgren-Lawrence grades 1 and 2 were included in group 1, while those with Kellgren-Lawrence grades 3 and 4 were included in group 2. Patients with cartilage grades 1-3 were included in group 1, while those with cartilage grades 4-6 were included in group 2. Patients were clinically assessed using a visual analog scale and the Western Ontario and McMaster Universities Arthritis Index. Radiographic osteoarthritis grade was scored using the Kellgren and Lawrence grading system. Using ultrasonography, symptomatic knees were graded and evaluated for distal femoral cartilage thickness. Carotid intima-media thickness and serum lipid levels were measured to assess atherosclerosis. [Results] Carotid intima-media thickness measurements were higher in group 2 than in group 1 as determined by the Kellgren-Lawrence and cartilage grading systems. Carotid intima-media thickness measurements were positively correlated with both the ultrasonographic cartilage grade and Kellgren-Lawrence. [Conclusion] The results of this study suggest that osteoarthritis as assessed by ultrasonography was successful and comparable to assessment with radiography. We showed a correlation between atherosclerosis and ultrasonographic knee osteoarthritis grade.
PubMed | Osmangazi University
Type: Comparative Study | Journal: The Annals of otology, rhinology, and laryngology | Year: 2012
We sought to analyze and compare the problems and technical difficulties related to surgical intervention, patient satisfaction, and quality of life after primary and secondary rhinoplasties.A total of 168 cases of rhinoplasty were grouped as primary or secondary according to the patients history of rhinoplasty. The type of nasal deformity, the surgical approach, and the difficulty of the surgery were recorded. The levels of patient satisfaction and the quality of life were assessed before and after the operation with the Rhinoplasty Outcomes Evaluation (ROE) and European Quality of Life-5 Dimension (EQ-5D) questionnaires. A quantitative and statistical analysis was performed.Thirty-three patients had secondary rhinoplasty, and 135 patients had primary rhinoplasty. Relatively high rates of saddle nose deformity, crooked nose, and tip asymmetry were observed in the secondary rhinoplasty group. The preoperative and postoperative scores on the ROE and EQ-5D questionnaires demonstrated statistically significant differences in both the primary and secondary rhinoplasty groups. The comparison of postoperative change between the primary and secondary rhinoplasty groups did not demonstrate a statistically significant difference.The surgical difficulty of secondary rhinoplasty is approximately twice that of primary rhinoplasty because of the high rate of major deformities. However, the levels of patient satisfaction and improvements in quality of life are similar after primary and secondary rhinoplasties.