Osaka, Japan
Osaka, Japan

Osaka University , or Handai , is a national university located in Osaka, Japan. It is the sixth oldest university in Japan as the Osaka Prefectural Medical College, and one of Japan's National Seven Universities. Numerous prominent scientists have worked at Osaka University such as the Nobel Laureate in Physics Hideki Yukawa. Wikipedia.


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Provided are a novel hemagglutinin that can remove cells deviated from the undifferentiated state, the cells being cells that emerge in a colony during culture of stem cells having pluripotency, and a novel method for culturing stem cells having pluripotency, the method using hemagglutinin. Provided is a mutant hemagglutinin complex protein derived from Clostridium botulinum type B, the complex protein containing at least subcomponents HA2 and HA3 of hemagglutinin derived from Clostridium botulinum type B, and the complex protein containing amino acids constituting a glycosylation site, with at least one of the amino acids having been mutated. Provided is a method for culturing stem cells having pluripotency, the method including culturing the stem cell having pluriopotency in the presence of a mutant hemagglutinin complex protein of the present disclosure.


Patent
Osaka University | Date: 2017-05-03

The present invention provides an antiperspirant which can effectively and safely control perspiration. The antiperspirant in accordance with an aspect of the present invention contains a mTOR inhibitor. The mTOR inhibitor can be rapamycin, a rapamycin derivative, or the like, and the antiperspirant can be used against hyperhidrosis and the like.


Patent
Menicon Co. and Osaka University | Date: 2017-05-17

It is an object of the present invention to provide a visibility-ensuring material which is capable of ensuring a surgical field for a predetermined time period, which does not inhibit the transmission of light, and which is capable of ensuring the visibility with which even delicate operations can be satisfactorily performed. A visibility-ensuring material of the present invention includes a gel-like viscoelastic body and has a storage elastic modulus during use of from 40 Pa to 700 Pa. A discharge device for a visibility-ensuring material of the present invention includes: a syringe; and at least one kind selected from the group consisting of a mesh filter, a needle, and an application nozzle.


Patent
Osaka University | Date: 2017-05-17

A measuring device (1) includes a first signal generation section (3) and a first removal section (5). The first signal generation section (3) generates a first source signal (x1(t)) including a fundamental and a plurality of harmonics based on a first physical quantity (p1) and a second physical quantity (p2). The first removal section (5) removes some or all of the harmonics from the first source signal (x1(t)). The first source signal (x1(t)) is a periodic signal, and one period of the first source signal (x1(t)) includes a first signal (p1), a second signal (p2), and a reference signal (pr). The first signal (p1) has a first duration (w1) and indicates the first physical quantity (p1). The second signal (p2) has a second duration (w2) and indicates the second physical quantity (p2). The reference signal (pr) has a third duration (w3) and indicates the reference physical quantity (pr).


The present invention provides a novel technique in a cell culture method using a cell culture vessel coated with a laminin fragment, which novel technique achieves cell culture as in the case of using a recommended coating concentration even when the coating concentration is lower than the recommended coating concentration. The present invention relates to a method for enhancing an activity for mammalian cultured cells of a laminin fragment or a variant thereof each having integrin binding activity,the method comprising bringing a culture surface of a cell culture vessel into contact with a coating solution containing the laminin fragment or a variant thereof and a protein that is neither a laminin nor a laminin fragment, thereby achieving coating of the culture surface with the laminin fragment or a variant thereof,the coating solution containing the laminin fragment or a variant thereof in such an amount that the culture surface is coated at a concentration lower than 0.5 g/cm^(2), andthe protein that is neither a laminin nor a laminin fragment being present at a concentration of 50 g/mL or higher in the coating solution.


Patent
Osaka University | Date: 2017-06-28

Provided are a PCR method and a PCR kit each of which has higher detection accuracy and is more convenient. A PCR method of the present invention subjects a sample to a PCR reaction, the sample containing: a primer set including a first primer and a second primer; a template amplified by the primer set; a first probe which loses at least one bulge structure in a case where a double strand is formed by the first probe and the first primer and which forms the at least one bulge structure by being dissociated from the double strand formed by the first probe and the first primer; and a bulge structure-binding molecule which emits a signal by binding to the at least one bulge structure.


The present invention provides a method for preparing a clinically applicable, safe and less damaged cardiomyocyte population through a brief and simple procedure from a cell population obtained by induced differentiation of pluripotent stem cells into cardiomyocytes. The present invention relates to a method for preparing a cardiomyocyte population, the method comprising the steps of:(1) inducing pluripotent stem cells to differentiate into cardiomyocytes,(2) bringing a cell population obtained by the induced differentiation into contact with a laminin selected from the group consisting of laminin 211, laminin 221, laminin 111 and laminin 121, or a fragment thereof having integrin binding activity, and(3) retrieving cells adherent to the laminin or the laminin fragment.


Patent
Osaka University and Toray Industries Inc | Date: 2017-08-09

An object of the present invention is to provide a device, a method, a program, and a recording medium with the program recorded thereon, for calculating a difference in free energy between different molecules at a high speed with a high accuracy. In order to achieve the object, the device, the method, the program, and the recording medium with the program recorded thereon according to the present invention calculate G based on the following numerical formula (1).


Patent
Yokohama City University, Osaka University and Nagoya University | Date: 2017-08-09

Means which enables preparation of a thick cell aggregate by a simple process without an operation of detaching and stacking of cells is disclosed. The method for preparing a three-dimensional cell aggregate by the present invention comprises: a cell encasing step of placing a cell suspension in a cell container; and a pressure application step of applying pressure to cells in the container. The cell encasing step and the pressure application step may be carried out a plurality of times. By the present invention, a thick, robust cell aggregate can be obtained by a simple operation of applying pressure to a cell suspension or a medium containing cells. Since the method does not require an operation of stacking a plurality of cell sheets, the cells are hardly damaged, and the conditions of the cells can be favorably maintained, so that the cells can be advantageously used as a tissue piece for transplantation.


Patent
Osaka University | Date: 2017-08-02

An object of the present invention is to provide a novel peptide and a novel immunostimulant or hair grower containing the peptide as an active ingredient. The present invention provides a peptide of 23 or less amino acids comprising the amino acid sequence LHRLKRLRKRL (SEQ ID NO: 1), preferably the amino acid sequence LHRLKRLRKRLK (SEQ ID NO: 9), and also provides an immunostimulant containing the peptide, a vaccine adjuvant containing the peptide, a vaccine composition containing the peptide, and a hair grower containing the peptide.

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