Osaka, Japan
Osaka, Japan

Osaka University , or Handai , is a national university located in Osaka, Japan. It is the sixth oldest university in Japan as the Osaka Prefectural Medical College, and one of Japan's National Seven Universities. Numerous prominent scientists have worked at Osaka University such as the Nobel Laureate in Physics Hideki Yukawa. Wikipedia.


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Provided are a novel hemagglutinin that can remove cells deviated from the undifferentiated state, the cells being cells that emerge in a colony during culture of stem cells having pluripotency, and a novel method for culturing stem cells having pluripotency, the method using hemagglutinin. Provided is a mutant hemagglutinin complex protein derived from Clostridium botulinum type B, the complex protein containing at least subcomponents HA2 and HA3 of hemagglutinin derived from Clostridium botulinum type B, and the complex protein containing amino acids constituting a glycosylation site, with at least one of the amino acids having been mutated. Provided is a method for culturing stem cells having pluripotency, the method including culturing the stem cell having pluriopotency in the presence of a mutant hemagglutinin complex protein of the present disclosure.


Patent
Osaka University | Date: 2017-05-03

The present invention provides an antiperspirant which can effectively and safely control perspiration. The antiperspirant in accordance with an aspect of the present invention contains a mTOR inhibitor. The mTOR inhibitor can be rapamycin, a rapamycin derivative, or the like, and the antiperspirant can be used against hyperhidrosis and the like.


Patent
Menicon Co. and Osaka University | Date: 2017-05-17

It is an object of the present invention to provide a visibility-ensuring material which is capable of ensuring a surgical field for a predetermined time period, which does not inhibit the transmission of light, and which is capable of ensuring the visibility with which even delicate operations can be satisfactorily performed. A visibility-ensuring material of the present invention includes a gel-like viscoelastic body and has a storage elastic modulus during use of from 40 Pa to 700 Pa. A discharge device for a visibility-ensuring material of the present invention includes: a syringe; and at least one kind selected from the group consisting of a mesh filter, a needle, and an application nozzle.


Patent
Osaka University | Date: 2017-05-17

A measuring device (1) includes a first signal generation section (3) and a first removal section (5). The first signal generation section (3) generates a first source signal (x1(t)) including a fundamental and a plurality of harmonics based on a first physical quantity (p1) and a second physical quantity (p2). The first removal section (5) removes some or all of the harmonics from the first source signal (x1(t)). The first source signal (x1(t)) is a periodic signal, and one period of the first source signal (x1(t)) includes a first signal (p1), a second signal (p2), and a reference signal (pr). The first signal (p1) has a first duration (w1) and indicates the first physical quantity (p1). The second signal (p2) has a second duration (w2) and indicates the second physical quantity (p2). The reference signal (pr) has a third duration (w3) and indicates the reference physical quantity (pr).


Patent
Quantum Biosystems and Osaka University | Date: 2016-11-04

The present disclosure provides methods and structures for effectuating nanoelectrodes with an adjustable nanogap. Devices with integrated actuators (e.g., piezoelectric devices) and/or materials with different coefficients of expansion are described. Also described are methods for calibrations nanoelectrode pairs.


Patent
Osaka University | Date: 2016-11-04

The present disclosure provides devices, systems and methods for effectuating nanoelectrodes for use with determining the sequence of double stranded biopolymers. Various modified bases and different metals may be utilized alone or in combination so as to provide differentiation between different nucleobases and to determine which base is associated with which strand.


Patent
Osaka University | Date: 2016-11-01

The present disclosure provides methods and structures for systems which can linearize and capture a nucleic acid molecule (e.g., DNA) for re-measurement of the nucleic acid molecule or other polymer prior to detection of the polymer. The structures may allow for quick exchange between different samples or other reagents.


The present invention provides a novel technique in a cell culture method using a cell culture vessel coated with a laminin fragment, which novel technique achieves cell culture as in the case of using a recommended coating concentration even when the coating concentration is lower than the recommended coating concentration. The present invention relates to a method for enhancing an activity for mammalian cultured cells of a laminin fragment or a variant thereof each having integrin binding activity,the method comprising bringing a culture surface of a cell culture vessel into contact with a coating solution containing the laminin fragment or a variant thereof and a protein that is neither a laminin nor a laminin fragment, thereby achieving coating of the culture surface with the laminin fragment or a variant thereof,the coating solution containing the laminin fragment or a variant thereof in such an amount that the culture surface is coated at a concentration lower than 0.5 g/cm^(2), andthe protein that is neither a laminin nor a laminin fragment being present at a concentration of 50 g/mL or higher in the coating solution.


Patent
Osaka University | Date: 2017-06-28

Provided are a PCR method and a PCR kit each of which has higher detection accuracy and is more convenient. A PCR method of the present invention subjects a sample to a PCR reaction, the sample containing: a primer set including a first primer and a second primer; a template amplified by the primer set; a first probe which loses at least one bulge structure in a case where a double strand is formed by the first probe and the first primer and which forms the at least one bulge structure by being dissociated from the double strand formed by the first probe and the first primer; and a bulge structure-binding molecule which emits a signal by binding to the at least one bulge structure.


Patent
Mitsuboshi Diamond Industrial Co. and Osaka University | Date: 2017-07-05

In an optical fiber device having a configuration in which an optical fiber is joined to a side surface of another optical fiber, a joint portion is suppressed from reaching a high temperature. The optical fiber device includes a first fluoride fiber (3), a second fluoride fiber (4), and a heat dissipation member (6). The first fluoride fiber (3) guides light. The second fluoride fiber (4) has a first end on or from which light is incident or output and a second end at which an end surface of the second fluoride fiber is obliquely joined to a side surface of the first fluoride fiber (3). The heat dissipation member (6) is disposed so as to cover the entire circumference of a joint portion of the first fluoride fiber (3) and the second fluoride fiber (4), and has a thermal conductivity equal to or greater than that of the first and second fibers (3, 4) and a property of transmitting light guided by the fibers.

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