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Kishida H.,Osaka Prefectoral Medical Center for Respiratory and Allergic Diseases | Yoshioka E.,Osaka Prefectoral Medical Center for Respiratory and Allergic Diseases | Maeda N.,Osaka Prefectoral Medical Center for Respiratory and Allergic Diseases | Yoshida N.,Osaka Prefectoral Medical Center for Respiratory and Allergic Diseases | And 2 more authors.
Skin Research | Year: 2012

We report a 4-month-old male infant with dermatosis induced by biotin deficiency. He had been fed by hydrolyzed milk since a few days after birth, because of frequent vomiting after each breast feeding. He was suspected to have food protein-induced enterocolitis syndrome. At 4 months of age, well-demarcated erosive erythema at intertriginous areas and hair loss of the scalp appeared and gradually worsened. Biotin deficiency was suspected as he had been fed only hydrolyzed milk. His skin symptoms were significantly improved after two weeks administration of biotin 2 mg/day. After finishing weaning at 8 months of age, cessation of oral administration of biotin induced no relapse of skin lesions. Nutritional deficiency of biotin is quite rare as it is contained in various foods and also synthesized by enteric flora. However, in Japan more than 30 infantile cases have been previously reported. Japanese milk formula for allergic or metabolic disorders rarely contains biotin because the addition of biotin to breast-milk substitutes is not legally allowed. Infants who have disorders that require nutritional support by only such formulas from the early newborn period have a high risk of biotin deficiency in Japan. Source

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