Osaka Kawasaki Rehabilitation University
Kaizuka, Japan

Osaka Kawasaki Rehabilitation University is a private university in Kaizuka, Osaka, Japan. The predecessor of the school was founded in 1997, and it was chartered as a university in 2006. Wikipedia.

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Liu Z.,Wakayama Medical University | Liu Z.,Shandong University | Zhou G.,Shandong University | Nakamura M.,Osaka Kawasaki Rehabilitation University | And 6 more authors.
Cancer Science | Year: 2011

There is a continuous debate regarding the classification of thyroid follicular lesions and the term "well-differentiated tumor of uncertain malignant potential (WDT-UMP)" was recently introduced to cover this problematic spectrum of tumors. The objective of this study was to reappraise WDT-UMP using morphological, immunochemical, and molecular analysis and to shed more light on encapsulated thyroid follicular-patterned tumors. A total of 30 cases of WDT-UMP with equivocal papillary thyroid carcinoma-type nuclear changes (PTC-N) or focal unequivocal PTC-N were examined. As a control, follicular adenoma (n = 29), follicular carcinoma (n = 8), hyalinizing trabecular adenoma (n = 5), and PTC (n = 48) were included. HBME-1, cytokeratin 19, and galectin-3 were positive in 12 (40.0%), 10 (33.3%) and 11 (36.7%) cases of WDT-UMP, respectively. According to the positivity of those markers, significant differences were obtained between WDT-UMP and PTC encapsulated common type (P = 0.028, 0.010, and 0.004, respectively), infiltrative follicular variant (P = 0.020, 0.026, and 0.008, respectively), and infiltrative common type (P = 0.004, 0.001, and 0.005, respectively), but not between WDT-UMP and follicular adenoma or follicular carcinoma. BRAFV600E mutation was absent but RET/PTC1 rearrangement was found in only two (6.7%) cases of WDT-UMP. None of the 20 patients with WDT-UMP developed recurrence, with an average follow-up of 80 months. These findings indicate that WDT-UMP has a favorable outcome and is distinct from PTC in morphological, immunohistochemical, and molecular characteristics. We propose that WDT-UMP should be classified as "well-differentiated tumor with uncertain behavior". © 2010 Japanese Cancer Association.

Kono R.,Wakayama Medical University | Okuno Y.,Wakayama National College of Technology | Nakamura M.,Osaka Kawasaki Rehabilitation University | Inada K.-I.,Aichi University | And 4 more authors.
Food Chemistry | Year: 2013

Angiotensin II (Ang II) is a vasoactive hormone that has been implicated in cardiovascular diseases. Here, the effect of peach, Prunus persica L. Batsch, pulp extract on Ang II-induced intracellular Ca2+ mobilization, reactive oxygen species (ROS) production and signal transduction events in cultured vascular smooth muscle cells (VSMCs) was investigated. Pretreatment of peach ethyl acetate extract inhibited Ang II-induced intracellular Ca 2+ elevation in VSMCs. Furthermore, Ang II-induced ROS generation, essential for signal transduction events, was diminished by the peach ethyl acetate extract. The peach ethyl acetate extract also attenuated the Ang II-induced phosphorylation of epidermal growth factor receptor and myosin phosphatase target subunit 1, both of which are associated with atherosclerosis and hypertension. These results suggest that peach ethyl acetate extract may have clinical potential for preventing cardiovascular diseases by interfering with Ang II-induced intracellular Ca2+ elevation, the generation of ROS, and then blocking signal transduction events. © 2013 Elsevier Ltd. All rights reserved.

Hori K.,Niigata University | Tamine K.,Osaka University | Barbezat C.,University of Geneva | Maeda Y.,Osaka University | And 3 more authors.
Dysphagia | Year: 2011

The purpose of this study was to investigate the influence of chin-down posture and bolus size on tongue pressure during swallowing. Eleven healthy volunteers (7 men, 4 women; age range = 26-59 years) participated in the experiments. Tongue pressure during dry and 5- and 15-ml water swallows in neutral and chin-down postures was measured using a sensor sheet system with five measuring points on the hard palate. Sequential order, maximal magnitude, duration, and integrated value of tongue pressure at each measuring point were compared between postures and bolus sizes. Onset of tongue pressure at posterior- circumferential parts occurred earlier in dry swallow than in 5- and 15-ml water swallows in each posture. Chindown posture was most effective for increasing tongue pressure in the 5-ml water swallow compared with dry swallow and the 15-ml water swallow, but it had almost no influence on tongue pressure with the 15-ml water swallow. These results suggest that chin-down posture increases the tongue driving force for small boluses in healthy subjects, which can be interpreted to mean that oropharyngeal swallowing in a chin-down posture requires more effort. © Springer Science+Business Media, LLC 2010.

Furui T.,Osaka Kawasaki Rehabilitation University | Furui M.,Society for Health and Life of People with Cerebral Palsy | Shiraishi K.,Diaster Support Center for Persons with Disabilities
i-CREATe 2013 - International Convention on Rehabilitation Engineering and Assistive Technology, in Conjunction with SENDEX 2013 | Year: 2013

Background: Japanese suicide incidence has been exceeded over 30,000 cases in past seven years after 2002, and increasing suicide aged older than 65. Health conditions and stigmatized disabilities are often pointed out the reason. Study question: How can people with Cerebral Palsy contribute for elderly people to overcome the stigma for disablement and illness? Method: A suggestive Case Story was described to consider the issue between disability and aging. Results and Discussion: In the early 1950's, being diagnosed with Cerebral Palsy (CP) was being a fatal illness. On the train home after being told that a baby has CP, the mother was about to jump from the running train with the baby daughter in her arms. More than a half a century later, the mother suffers from impairments from a traumatic brain injury caused by a car accident, also has depression, tumors, and dementia. During that half a century, the daughter, the one people thought "should not exist", lived independently in the community, acquiring the social skills and knowledge, utilizing the technologies and services available and getting the care she need. This lifelong achievement is what the mother ultimately relied on. The mother left her home and is living with the daughter after she needs a long-term care. Most elderly people who need care never know how to live with their disabilities. Worse still, they were perfectly "normal" all their life, and now suddenly they feel "abnormal". This causes embarrassment, confusion, and panic. This is where people with CP can help. People with CP are like "experts" at being lifelong disabled.

Hisari A.,Osaka Electro-Communication University | Hisari A.,Osaka Kawasaki Rehabilitation University | Sekine M.,Osaka Electro-Communication University | Yoshida M.,Osaka Electro-Communication University
IFMBE Proceedings | Year: 2014

To use their toes to support their body weight is one of the ways for people to improve standing balance. Some people undergoing this training (toes weight-bearing exercise) do not know how to use their toes to support their body weight. In the present study, biofeedback equipment was developed to help understand how to use the toes to support the body weight, and the effects of biofeedback were examined. As the results, ratios of mean toe to whole plantar load values (toe-loading rates) increased about 10% of body weight as the effects of biofeedback. © Springer International Publishing Switzerland 2014.

Kono R.,Wakayama Medical University | Okuno Y.,Wakayama National College of Technology | Inada K.-I.,Aichi University | Tokuda A.,Wakayama Medical University | And 4 more authors.
Bioscience, Biotechnology and Biochemistry | Year: 2011

Osteoporosis is a serious disease caused by decreased bone mass. There is constant matrix remodeling in bones, by which bone formation is performed by osteoblastic cells, whereas bone resorption is accomplished by osteoclast cells. We investigated the effect of a Japanese apricot (Prunus mume SIBE. et ZUCC.) extract on the proliferation and osteoblastic differentiation in pre-osteoblastic MC3T3-E1 cells. An alkaline phosphatase (ALP) activity assay, cell proliferation assay, alizarin red staining and expression analysis of osteoblastic genes were carried out to assess the proliferation and osteoblastic differentiation. The water-soluble fraction of Prunus mume (PWF) increased the ALP activity, cell proliferation and mineralization. The gene expression of osteopontin and bone morphogenetic protein-2, which are markers in the early period of osteoblastic differentiation, were significantly enhanced by the PWF treatment. PWF therefore stimulated the proliferation and osteoblastic differentiation of cells and may have potential to prevent osteoporosis.

PubMed | Hiroshima University, Health Science University, Osaka Kawasaki Rehabilitation University and Prefectural University of Hiroshima
Type: Journal Article | Journal: Journal of physical therapy science | Year: 2016

[Purpose] This study examined the possibility of maintaining skin extensibility by stretching the skin involved in disuse joint contracture. [Subjects and Methods] The study was carried out using 18 male Wistar rats. The rats were randomly allocated to three groups. The control group received no intervention for the right ankle joint, the fixation group received one-weeks fixation of the right ankle joint in maximum plantar-flexion with a cast, and the stretching group received continuous stretching of the skin over the Achilles tendon for 30min once daily for one week with the cast removed during the skin stretching, but the joint was not moved. On the final day, skin extensibility of the skin from the posterior aspect of the ankle joint was determined using a tensile strength tester and a length-tension curve. [Results] Statistical analysis of the data revealed significant differences in the skin extensibility among the three groups. The stretching group showed significantly greater improvement of skin extensibility than the fixation group. [Conclusion] Skin stretching without moving the joint was demonstrated to be useful for maintaining skin extensibility.

PubMed | Wakayama Medical University, Osaka Kawasaki Rehabilitation University, Tokyo Medical University and Kansai Medical University
Type: Journal Article | Journal: BMC geriatrics | Year: 2016

A concept referred to as locomotive syndrome (LS) was proposed by the Japanese Orthopaedic Association in order to help identify middle-aged and older adults who may be at high risk of requiring healthcare services because of problems associated with locomotion. Cardiometabolic disorders, including obesity, hypertension, diabetes, and dyslipidemia, have a high prevalence worldwide. The purpose of this study was to determine the associations between LS and both body composition and cardiometabolic disorders.The study participants were 165 healthy adult Japanese women volunteers living in rural areas. LS was defined as a score 16 on the 25-question Geriatric Locomotive Function Scale (GLFS-25). Height, body weight, body fat percentage, body mass index (BMI), and bone status were measured. Bone status was evaluated by quantitative ultrasound (i.e., the speed of sound [SOS] of the calcaneus) and was expressed as the percent of Young Adult Mean of the SOS (%YAM). Comorbid conditions of hypertension, hyperlipidemia, and diabetes were assessed using self-report questionnaires.Twenty-nine participants (17.6 %) were classed as having LS. The LS group was older, shorter, and had a higher body fat percentage, a higher BMI, and lower bone status than the non-LS group. Multiple logistic regression analysis showed that participants with a BMI 23.5 kg/mThese findings suggest that BMI may be a useful screening tool for LS. Furthermore, because hypertension and diabetes were associated with LS, the prevention of these disorders accompanied by weight management may help protect against LS.

PubMed | Osaka Kawasaki Rehabilitation University
Type: Journal Article | Journal: Journal of geriatric physical therapy (2001) | Year: 2015

The Japanese Orthopaedic Association proposed a concept called locomotive syndrome (LS) to identify middle-aged and older adults at high risk of requiring health care services because of problems with locomotion. It is important to identify factors associated with the development of LS. Physical performance measures such as walking speed and standing balance are highly predictive of subsequent disability and mortality in older adults. However, there is little evidence about the relationship between physical performance measures and LS.To determine the physical performance measures associated with LS, the threshold values for discriminating individuals with and without LS, and the odds ratio of LS according to performance greater than or less than these thresholds in middle-aged and older Japanese women.Participants were 126 Japanese women (mean age = 61.8 years). Locomotive syndrome was defined as a score of 16 or more on the 25-question Geriatric Locomotive Function Scale. Physical performance was evaluated using grip strength, unipedal stance time with eyes open, seated toe-touch, and normal and fast 6-m walk time (6 MWT). Variables were compared between LS and non-LS groups.Fourteen participants (11.1%) were classed as having LS. Unipedal stance time, normal 6 MWT, and fast 6 MWT were significantly different between the 2 groups. The LS group had a shorter unipedal stance time and a longer normal and fast 6 MWT than the non-LS group. For these 3 variables, the area under the receiver operating characteristic curve was greater than 0.7, and the threshold for discriminating the non-LS and LS groups was 15 s for unipedal stance time, 4.8 s for normal 6 MWT and 3.6 s for fast 6 MWT. These variables were entered into a multiple logistic regression analysis, which indicated that unipedal stance time less than 15 s was significantly related to LS (odds ratio = 8.46; P < .01).Unipedal stance time was the physical performance measure that was most strongly associated with LS. This measure may be useful for early detection of LS.

PubMed | Wakayama National College of Technology, Osaka Kawasaki Rehabilitation University, Aichi University, Teikyo University and 2 more.
Type: Journal Article | Journal: Acta histochemica et cytochemica | Year: 2014

Granulosa cells form ovarian follicles and play important roles in the growth and maturation of oocytes. The protection of granulosa cells from cellular injury caused by oxidative stress is an effective therapy for female infertility. We here investigated an effective bioactive compound derived from Prunus mume seed extract that protects granulosa cells from hydrogen peroxide (H2O2)-induced apoptosis. We detected the bioactive compound, 3,4-dihydroxybenzaldehyde (3,4-DHBA), via bioactivity-guided isolation and found that it inhibited the H2O2-induced apoptosis of granulosa cells. We also showed that 3,4-DHBA promoted estradiol secretion in granulosa cells and enhanced the mRNA expression levels of steroidogenic factor 1, a promoter of key steroidogenic enzymes. These results suggest that P. mume seed extract may have clinical potential for the prevention and treatment of female infertility.

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