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Kaizuka, Japan

Osaka Kawasaki Rehabilitation University is a private university in Kaizuka, Osaka, Japan. The predecessor of the school was founded in 1997, and it was chartered as a university in 2006. Wikipedia.

Liu Z.,Shandong University | Liu Z.,Wakayama Medical University | Zhou G.,Shandong University | Nakamura M.,Osaka Kawasaki Rehabilitation University | And 6 more authors.
Pathology International | Year: 2011

The expression of retinoid X receptor γ (RXRγ) and the clinicopathological parameters of total 69 patients with papillary thyroid carcinoma (PTC) larger than 1cm were examined. The PTCs were classified into two groups according to the presence of loss of cellular polarity/cohesiveness (LOP/C). The expression of RXRγ mRNA was examined by reverse transcriptase polymerase chain reaction and quantitative real-time PCR. The RXRγ mRNA up-regulation was found to be positively correlated with extrathyroid invasion (r=0.293, P=0.019), advanced tumor stage (r=0.318, P=0.016) and lymph node metastasis (LNM) (r=0.338, P=0.005), as well as LOP/C (r=0.345, P=0.004), which was proposed as a histological characteristic of poor cellular differentiation. The RXRγ mRNA expression, as well as extrathyroid invasion, LOP/C and advanced tumor stage, was further confirmed to be one of the independent predictive factors (Odds ratio: 6.545; 95% confidence interval: 1.575-27.208) of LNM using multivariate analysis. These results suggest that RXRγ may play a role in the dedifferentiation and metastasis of PTC. © 2010 The Authors. Pathology International © 2010 Japanese Society of Pathology and Blackwell Publishing Asia Pty Ltd.

Hori K.,Niigata University | Tamine K.,Osaka University | Barbezat C.,University of Geneva | Maeda Y.,Osaka University | And 3 more authors.
Dysphagia | Year: 2011

The purpose of this study was to investigate the influence of chin-down posture and bolus size on tongue pressure during swallowing. Eleven healthy volunteers (7 men, 4 women; age range = 26-59 years) participated in the experiments. Tongue pressure during dry and 5- and 15-ml water swallows in neutral and chin-down postures was measured using a sensor sheet system with five measuring points on the hard palate. Sequential order, maximal magnitude, duration, and integrated value of tongue pressure at each measuring point were compared between postures and bolus sizes. Onset of tongue pressure at posterior- circumferential parts occurred earlier in dry swallow than in 5- and 15-ml water swallows in each posture. Chindown posture was most effective for increasing tongue pressure in the 5-ml water swallow compared with dry swallow and the 15-ml water swallow, but it had almost no influence on tongue pressure with the 15-ml water swallow. These results suggest that chin-down posture increases the tongue driving force for small boluses in healthy subjects, which can be interpreted to mean that oropharyngeal swallowing in a chin-down posture requires more effort. © Springer Science+Business Media, LLC 2010.

Kono R.,Wakayama Medical University | Okuno Y.,Wakayama National College of Technology | Nakamura M.,Osaka Kawasaki Rehabilitation University | Inada K.-I.,Aichi University | And 4 more authors.
Food Chemistry | Year: 2013

Angiotensin II (Ang II) is a vasoactive hormone that has been implicated in cardiovascular diseases. Here, the effect of peach, Prunus persica L. Batsch, pulp extract on Ang II-induced intracellular Ca2+ mobilization, reactive oxygen species (ROS) production and signal transduction events in cultured vascular smooth muscle cells (VSMCs) was investigated. Pretreatment of peach ethyl acetate extract inhibited Ang II-induced intracellular Ca 2+ elevation in VSMCs. Furthermore, Ang II-induced ROS generation, essential for signal transduction events, was diminished by the peach ethyl acetate extract. The peach ethyl acetate extract also attenuated the Ang II-induced phosphorylation of epidermal growth factor receptor and myosin phosphatase target subunit 1, both of which are associated with atherosclerosis and hypertension. These results suggest that peach ethyl acetate extract may have clinical potential for preventing cardiovascular diseases by interfering with Ang II-induced intracellular Ca2+ elevation, the generation of ROS, and then blocking signal transduction events. © 2013 Elsevier Ltd. All rights reserved.

Liu Z.,Wakayama Medical University | Liu Z.,Shandong University | Zhou G.,Shandong University | Nakamura M.,Osaka Kawasaki Rehabilitation University | And 6 more authors.
Cancer Science | Year: 2011

There is a continuous debate regarding the classification of thyroid follicular lesions and the term "well-differentiated tumor of uncertain malignant potential (WDT-UMP)" was recently introduced to cover this problematic spectrum of tumors. The objective of this study was to reappraise WDT-UMP using morphological, immunochemical, and molecular analysis and to shed more light on encapsulated thyroid follicular-patterned tumors. A total of 30 cases of WDT-UMP with equivocal papillary thyroid carcinoma-type nuclear changes (PTC-N) or focal unequivocal PTC-N were examined. As a control, follicular adenoma (n = 29), follicular carcinoma (n = 8), hyalinizing trabecular adenoma (n = 5), and PTC (n = 48) were included. HBME-1, cytokeratin 19, and galectin-3 were positive in 12 (40.0%), 10 (33.3%) and 11 (36.7%) cases of WDT-UMP, respectively. According to the positivity of those markers, significant differences were obtained between WDT-UMP and PTC encapsulated common type (P = 0.028, 0.010, and 0.004, respectively), infiltrative follicular variant (P = 0.020, 0.026, and 0.008, respectively), and infiltrative common type (P = 0.004, 0.001, and 0.005, respectively), but not between WDT-UMP and follicular adenoma or follicular carcinoma. BRAFV600E mutation was absent but RET/PTC1 rearrangement was found in only two (6.7%) cases of WDT-UMP. None of the 20 patients with WDT-UMP developed recurrence, with an average follow-up of 80 months. These findings indicate that WDT-UMP has a favorable outcome and is distinct from PTC in morphological, immunohistochemical, and molecular characteristics. We propose that WDT-UMP should be classified as "well-differentiated tumor with uncertain behavior". © 2010 Japanese Cancer Association.

Akihumi T.,Hakujukai | Yasushige F.,Osaka Kawasaki Rehabilitation University
Medical Journal of Minami Osaka Hospital | Year: 2011

The number of patients receiving terminal care in special elderly nursing homes has increased in recent years. In particular, the number of patients with tumors is increasing, and pain evaluation and control are thus becoming more important. However, few cases of terminal care in tumor patients have been reported, and systems available for pain evaluation and control in such patients are not yet satisfactory. To perform pain evaluation and control in a patient, we used multiple evaluation indicators, since use of only one subjective evaluation indicator, such as the Visual Analog Scale, made it difficult to determine patient condition and control pain. As a result, we could better understand the patient's complaints and determine the effects of pain on the patient's entire life by information sharing with other medical professionals. Combined use of several evaluation indicators was shown to be effective for physiotherapy and self-care in daily life settings.

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