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Kaida A.,Japan Institute for Environmental Sciences | Kubo H.,Japan Institute for Environmental Sciences | Takakura K.-I.,Japan Institute for Environmental Sciences | Togawa M.,Osaka City Sumiyoshi Hospital | And 3 more authors.
Japanese Journal of Infectious Diseases | Year: 2011

Human rhinovirus (HRV) is a causative agent of acute respiratory tract infection (ARTI). In 2007, a novel HRV group, HRV-C, was discovered. This study, which assessed whether HRV-C is epidemic among patients with ARTI, was aimed at analyzing the seasonal prevalence of HRV-C in Osaka City, Japan. Gene amplification tests were performed to detect 10 respiratory viruses in 336 specimens collected during November 2008-October 2009. In total, 364 viruses were detected in 271 specimens. The most commonly detected virus was HRV (n=84). For HRV-positive specimens, we conducted phylogenetic analyses using the VP4/VP2 gene region to identify the HRV species (HRV-C, 30; HRV-A, 54). Both the number and rate of HRV-C detection were highest in December. The highest numbers and the highest rate of HRV-A detection were obtained in April and June and in April, respectively. Statistical analysis showed that the most probable prevalent period of HRV-C was between September and March, and that of HRV-A was between March and November. These results suggest that HRV-C is mainly epidemic during autumn and early spring; this seasonal prevalence was different from that of HRV-A. Moreover, the HRV-C Osaka strains were scattered in many genetic clusters along with previously reported strains from different parts of the world. This result also emphasizes the worldwide circulation of HRV-C. Source

Onishi S.,Osaka City Sumiyoshi Hospital
Nihon rinsho. Japanese journal of clinical medicine | Year: 2012

Human norovirus (NoV) is an important cause of the epidemic acute gastroenteritis in children and adults. This review mentions on the required knowledge to understand morphology, genetics, transmission, pathogenesis, and control. The development of molecular diagnostic techniques is clarified the epidemiological impact that is now recognized not only as the major cause of foodborne gastroenteritis outbreaks but also as a cause of sporadic gastroenteritis. It was recognized that the combination pattern to an intestinal epithelium of NoV was prescribed in organization, blood type antigen (histoblood group antigen: HBGA). In children, NoV has various complications especially benign convulsions associated with mild gastroenteritis and associated-encephalopathy. NoV virus-like particle (VLP) vaccine is developing as the protection against acute viral gastroenteritis with a homologous virus. Source

Nakamura T.,Osaka City General Hospital | Yoshioka K.,Osaka City Sumiyoshi Hospital | Miyashita T.,Osaka City General Hospital | Ikeda K.,Osaka City General Hospital | And 3 more authors.
Internal Medicine | Year: 2012

A 23-year-old woman was admitted with complaints of swelling and pain in the left breast, fever, polyarthralgia and erythema nodosum. A fine-needle biopsy of the mass in the left breast revealed non-caseous granulomatous lobulitis. A diagnosis of granulomatous mastitis was thus made. The administration of prednisolone 40 mg/day resulted in the resolution of the patient's symptoms, and the breast mass thereafter decreased in size. The mass relapsed during the subsequent prednisolone taper. Additional therapy with methotrexate resulted in complete remission. Granulomatous mastitis should therefore be included in the differential diagnosis of polyarthralgia. © 2012 The Japanese Society of Internal Medicine. Source

Kaida A.,Japan Institute for Environmental Sciences | Kubo H.,Japan Institute for Environmental Sciences | Sekiguchi J.,Japan Institute for Environmental Sciences | Kohdera U.,Nakano Childrens Hospital | And 4 more authors.
Emerging Infectious Diseases | Year: 2011

Enterovirus 68 strains were detected in 14 specimens from children with respiratory tract infections and 1 specimen from a child with febrile convulsions during 2010 in Osaka, Japan. These strains had deletions in the 5′ untranslated region and were genetically different from reported strains. This virus is associated with respiratory tract infections in Japan. Source

Ohtani H.,Osaka City Sumiyoshi Hospital | Tamamori Y.,Osaka City Sumiyoshi Hospital | Noguchi K.,Osaka City Sumiyoshi Hospital | Azuma T.,Osaka City Sumiyoshi Hospital | And 5 more authors.
Journal of Surgical Research | Year: 2011

Background: Laparoscopy-assisted distal gastrectomy (LADG) for gastric cancer is a minimally invasive technique. We performed a meta-analysis of five randomized clinical trials (RCTs) to evaluate and compare the benefits of LADG with those of open distal gastrectomy (ODG). Methods: The present meta-analysis was based on the comparison of LADG with ODG for gastric cancer. The following factors were examined: operative time, estimated blood loss, number of harvested lymph nodes, time to resumption of oral intake, duration of hospital stay, frequency of analgesic administration, complications, tumor recurrence, and mortality. Results: We selected five RCTs to compare LADG with ODG for gastric cancer. A total of 326 patients with gastric cancer were included in this meta-analysis of whom 164 underwent LADG and 162 underwent ODG. There was a significant difference in the volume of intraoperative blood loss, period of hospital stay, frequency of analgesic administration, and rate of complications between LADG and ODG. There was no difference in the resumption of oral intake, rate of tumor recurrence, and mortality. The operative time was significantly longer and the number of harvested lymph nodes was significantly smaller in LADG than in ODG. Conclusion: LADG is significantly superior to ODG regarding the volume of blood loss, duration of hospital stay, level of pain, and risk of complications. There was no difference in the resumption of oral intake, rate of tumor recurrence, and mortality. However, LADG was significantly inferior to ODG regarding operative time and also had a smaller number of harvested lymph nodes. © 2011 Elsevier Inc. All rights reserved. Source

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