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Rao Y.J.,Orthopedic Hospital of Henan Province | Zhu W.X.,Orthopedic Hospital of Henan Province | Du Z.Q.,Orthopedic Hospital of Henan Province | Jia C.X.,Orthopedic Hospital of Henan Province | And 4 more authors.
Genetics and Molecular Research | Year: 2014

The aim of this study was to determine the effectiveness and safety of transplantation of olfactory ensheathing cells for functional repair of the spinal cord. An olfactory bulb was obtained from a 4- to 5-month-old aborted fetus, and it was digested into single olfactory ensheathing cells and then cultured and purified for 1 to 2 weeks. Under general anesthesia, these single-cell suspensions of olfactory ensheathing cells were injected into the corresponding spinal injury site with 0.45-mm-diameter injections. The American Spinal Injury Association (ASIA) Impairment Scale was used to evaluate spinal function. A total of 15 patients (12 men, 3 women; age range, 18-56 years; mean age, 40) were admitted for obsolete spinal injuries. Spinal functions of the 15 patients were observed and followed postoperatively for a period ranging from 2 weeks to 1 month. All the 15 patients exhibited improvements in spinal function, and the improvement tendencies continued. Twelve patients had obvious spinal function improvement, and three had slight improvement according to the ASIA scale, with an obvious difference between preoperation and postoperation measures (P < 0.05). No fevers, infections, functional deteriorations, or deaths were seen. Thus, transplantation of olfactory ensheathing cells promoted spinal and neurofunctional recovery in patients with malignant spinal injuries, and this therapeutic method was safe. © FUNPEC-RP.

Cui H.,Orthopedic Hospital of Henan Province | Guo J.,Orthopedic Hospital of Henan Province | Yang L.,Orthopedic Hospital of Henan Province | Guo Y.,Orthopedic Hospital of Henan Province | Guo M.,Orthopedic Hospital of Henan Province
Pakistan Journal of Medical Sciences | Year: 2015

Objective: To compare the clinical therapeutic effects of anterior decompression and posterior decompression on thoracolumbar spine fracture (TSF) complicated with spinal nerve injury (SNI). Methods: A total of 120 patients with TSF and SNI were selected and divided into a treatment group and a control group that were then treated by anterior decompression and posterior decompression respectively. The preoperative and postoperative motor scores, tactile scores, heights of injured vertebral body and Cobb’s angles, as well as surgical times and intraoperative blood losses were recorded and compared. Results: Before surgeries, the motor score, tactile score, height of injured vertebral body and Cobb’s angle of the treatment group were similar to those of the control group (P>0.05). After surgeries, the values of the treatment group were significantly different from those of the control group (P<0.05). The two groups also had significantly different intraoperative blood losses and surgical times (P<0.05). Conclusion: Compared with posterior decompression, anterior decompression improved spinal cord function better and relived spinal cord compression more effectively with a more reasonable mechanics of internal fixation. Although this protocol caused more blood loss, the overall therapeutic effects were more satisfactory. © 2015, Pak J Med Sci. All Rights Reserved.

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