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Okazaki, Japan

Zimmerman R.M.,Massachusetts General Hospital | Kalish L.A.,Harvard University | Hresko M.T.,Orthopedic Center | Waters P.M.,Orthopedic Center | Bae D.S.,Orthopedic Center
Journal of Bone and Joint Surgery - Series A | Year: 2013

Background: Management of pediatric radial neck fractures is controversial regarding acceptable alignment, variable reduction techniques, and suboptimal outcomes. The purpose of this study was to assess the characteristics, management, and results in a surgical cohort, in efforts to identify prognostic factors and offer treatment suggestions. It was hypothesized that less invasive reduction maneuvers would precede open reduction and that worse results would correlate with fracture severity, open reduction, and the presence of associated injuries. Methods: Retrospective analysis of 151 children in whom a radial neck fracture had been surgically treated from 2001 to 2011 was performed. The mean age (and standard deviation) and duration of follow-up were 8.4 ± 2.9 years and 13.3 ≥20.0 months, respectively; 40% of the patients were male. A successful clinical result was defined as elbow flexion of≥120° flexion contracture of <20°, forearm rotation of ≥90°with ≥45°of supination and pronation, and no complications.Results: An isolated radial neck fracture occurred in 54% of the children. The mean angulation and displacement improved from 43° ± 19° and 37% ± 35%, respectively, before treatment to 13°± 7° and 0.9% ± 4% after treatment (p < 0.001).Twenty-two procedural combinations were used to treat these patients, and 67% of the open reductions were not preceded bypercutaneous or closed reduction attempts. Among 131 patients with adequate follow-up, 31% had an unsuccessful outcome. An age of ten years or more (odds ratio [OR] = 5.85, p = 0.001), a time to surgery of two days or less (OR = 4.73,p = 0.02), and greater fracture displacement (OR = 1.25 per 10%, p = 0.001) were independent predictors of unsuccessful outcomes. Increased fracture severity and open reduction were associated with poor results, although the presence of concomitant injuries was not. It is predicted that closed manipulation will fail for half of fractures angulated ≥36°, and that half of fractures displaced ≥65% will require open reduction. The predicted frequency of unsuccessful outcomes is 50% with 76% displacement. Conclusions: There continues to be great variation in the approach to treatment of displaced radial neck fractures in children. Suboptimal results occurred in 31% of the patients in this series, with worse results in patients older than ten years, who had increased fracture severity, and who underwent open reduction. Less invasive reduction methods should precede open reduction whenever possible. Level of Evidence: Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence. © 2013 BY THE JOURNAL OF BONE AND JOINT SURGERY, INCORPORATED. Source


Vuillermin C.,Orthopedic Center | Butler L.,Charles ay Jr Hand Center | Lake A.,Charles ay Jr Hand Center | Ezaki M.,Charles ay Jr Hand Center | Oishi S.,Charles ay Jr Hand Center
Journal of Hand Surgery | Year: 2016

Purpose To report the functional outcomes associated with the flexor digitorum superficialis (FDS) opposition transfer for types II and IIIA thumb hypoplasia and determine if there is any noteworthy difference in the outcome dependent on the pulley used. Methods We included patients who underwent a ring FDS opposition transfer and had at least 2 years follow-up. The study group consisted of 36 patients with 40 treated thumbs. All patients underwent follow-up examination and standardized testing. Outcome functional measures were recorded using the Pediatric Outcomes Data Collection Instrument (PODCI). There were 9 type II and 31 type IIIA hypoplastic thumbs. All patients underwent a ring FDS opposition transfer and a 4-flap z-plasty for first web space deepening. The pulley for opposition was flexor carpi ulnaris in 19 and the transverse carpal ligament in 21. Thirty-six thumbs had ulnar collateral ligament reconstructions, with 5 of the 36 undergoing combined ulnar collateral ligament/radial collateral ligament stabilizations. Average follow-up was 7.6 years (range, 2-16 years). Results Average postoperative Kapandji score was 8 (range, 4-10). Grip, lateral pinch, and tripod pinch strengths averaged 46%, 49%, and 48% of age- and sex-matched normal controls, respectively. There was no significant difference between surgical pulleys used. The Pediatric Outcomes Data Collection Instrument global was 91 (range, 53-100), and PODCI happiness was 87 (range, 15-100). Conclusions We found the ring FDS opposition transfer to be an effective method for providing opposition for both type II and IIIA thumb hypoplasia. At follow-up, excellent opposition function and PODCI scores were noted, with no difference related to the type of pulley used. Type II thumbs had significantly greater grip and pinch strengths when compared with type IIIA thumbs. Type of study/level of evidence Therapeutic IV. © 2016 American Society for Surgery of the Hand. Source


Boffeli T.J.,Regions Hospital HealthPartners Institute for Education and Research | Thompson J.C.,Orthopedic Center | Tabatt J.A.,Essentia Health
Journal of Foot and Ankle Surgery | Year: 2016

Single-pin external Kirschner wire (K-wire) fixation has traditionally been a mainstay in proximal interphalangeal joint fusion for central hammertoe repair. Concerns over cosmesis, inconvenience, pin tract infection, hardware failure, nonunion, and early hardware removal have led to the development of implantable internal fixation devices. Although numerous implantable devices are now available and represent viable options for hammertoe repair, they are costly and often pose a challenge in the event removal becomes necessary. An alternative fixation option not typically used is a 2-pin K-wire fixation technique. The perceived advantage of obtaining 2 points of fixation compared with 1 across the fusion site is improved stability against the rotational and bending forces, thus decreasing the potential for pin-related complications. A retrospective assessment of 91 consecutive hammertoe repairs consisting of proximal interphalangeal joint fusion with 2-pin fixation in 60 patients was performed. The K-wires were removed at 6 weeks postoperatively, and the overall postoperative follow-up duration was 28.56 (range 1.40 to 86.83) months. Of the 91 digits, 89 (98%) did not encounter a complication postoperatively and 2 (2.20%) had sustained loosened or broken hardware. No postoperative infection was encountered. The low incidence of complications observed supports the 2-pin K-wire fixation technique as a low-cost and viable construct for proximal interphalangeal joint fusion hammertoe repair. © 2016 American College of Foot and Ankle Surgeons. Source


Huang J.,Orthopedic Center
Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery | Year: 2012

To investigate the anti-infection and bone repair effects of cationic liposome-encapsulated vancomycin combined with the nano-hydroxyapatite/chitosan/konjac glucomannan (n-HA/CS/KGM) composite scaffold in vivo. Fifty-one 6-month-old New Zealand white rabbits, weighing 1.5-3.0 kg, were selected to prepare chronic infectious tibia bone defect model by using Staphylococcus aureus. After 4 weeks, 48 survival rabbits were randomly divided into 4 groups (n=12). After debridement, defect was treated with nothing in group A, with n-HA/CS/KGM composite scaffold in group B, with vancomycin and n-HA/CS/KGM composite scaffold in group C, and with cationic liposome-encapsulated vancomycin and n-HA/CS/KGM composite scaffold in group D. After 8 weeks of treatment, general observation, X-ray, HE staining, the bacterial culture, and the measurement of the longest diameter of bone defect were done. At 4 weeks after modeling, 48 rabbits were diagnosed as having osteomyelitis, including periosteal new bone formation, destruction of bone, and soft tissue swelling. The Norden score was 3.83 +/- 0.52. At 8 weeks after treatment, sinus healed in groups C and D, but sinus was observed in groups A and B; the gross bone pathological scores of group D were significantly better than those of groups A and B (P < 0.05). Bone defects were repaired completely in group D, the results of the longest diameter of bone defects in group D was significantly better than those in the other 3 groups (P < 0.05). New bone formation was observed in groups C and D, but periosteal reaction and marrow low-density shadow were observed in groups A and B; Norden score in group D was significantly better than those in groups A, B, and C (P < 0.05). HE staining showed that there were a large number of trabecular bone formation and fibrosis, with no obvious signs of infection in groups C and D, but neutrophil accumulation was observed in groups A and B; Smeltzer scores in groups C and D were significantly better than those in groups A and B (P < 0.05). Bacteriological results showed higher negative rate in groups C and D than in groups A and B (P < 0.05). Cationic liposome-encapsulated vancomycin and n-HA/CS/KGM composite scaffold can be a good treatment for infectious bone defects in rabbits, providing a new strategy for the therapy of bone defects in chronic infection. Source


Tang H.,Orthopedic Center
Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery | Year: 2010

It is difficult to treat chronic osteomyelitis due to the formation of the Staphylococcus aureus biofilms. Liposomal gentamicin-impregnated allogeneic cortical bone can inhibit the formation of the Staphylococcus aureus biofilms. To explore the treatment of chronic osteomyelitis of rabbit by liposomal gentamicin-impregnated allogeneic cortical bone. The liposomal gentamicin, liposomal gentamicin-impregnated allogeneic cortical bone and gentamicin-impregnated allogeneic cortical bone were produced. Then the chronic Staphylococcus aureus osteomyelitis models of rabbit were made in left lower limbs of 40 6-month-old rabbits and the right lower limbs were used as controls. After 2 weeks, the observations of gross and X-ray were done. Four rabbits died within 10 days after the models were made and other 36 rabbits were divided into 6 groups: group A (no antibiotics), group B (intravenous injection of gentamicin), group C (intravenous injection of liposomal gentamicin), group D (implantation of gentamicin-impregnated allogeneic cortical bone), group E (implantation of liposomal gentamicin-impregnated allogeneic cortical bone), and group F (implantation of allogeneic cortical bone). After 2 weeks of treatment, the bacterial culture, X-ray and HE staining were done. The chronic Staphylococcus aureus osteomyelitis model of rabbit was made successfully. The X-ray showed dissolution of bone and periosteal reaction in groups A, B, C, and F, and no obvious dissolution of bone and periosteal reaction in groups D and E. The Norden scores were (2.5 +/- 0.3), (2.1 +/- 0.2), (1.5 +/- 0.3), (1.5 +/- 0.2), (0.9 +/- 0.3), and (2.7 +/- 0.3) points in groups A-F, respectively; showing significant differences between group A and groups B-E (P < 0.05), between groups B, E, F and other groups (P < 0.05). The results of blood and marrow cultures for Staphylococcus aureus were positive in groups A and F, and negative in other 4 groups; the results of bone marrow culture for Staphylococcus aureus were positive in 6 rabbits of group B, 4 rabbits of group C and 3 rabbits of group D; and the results were negative in group E. HE staining showed: in groups A and F, abscess and dead bone formed, and no new bone formation were observed; in groups B and C, different degrees of neutrophil accumulation was seen; in group D, some neutrophil accumulation occurred, and osteoprogenitor cells and osteoclasts were seen around implanted bone; and in group E, no neutrophil accumulation was observed, a lot of granulation tissues formed, and osteoprogenitor cells and osteoclasts were seen around implanted bone. Implantation of liposomal gentamicin-impregnated allogeneic cortical bone has remarkably better effect in treating chronic osteomyelitis than intravenous injection of liposomal gentamicin and implantation of gentamicin-impregnated allogeneic cortical bone. Source

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