Entity

Time filter

Source Type

Bolbec, France

Gembus V.,INSA Rouen | Janvier S.,Oril Industries | Lecouve J.-P.,Oril Industries | Gloanec P.,Institute Of Recherches Servier | And 2 more authors.
European Journal of Organic Chemistry | Year: 2010

We describe a new route to access important pharmaceutical intermediates for the synthesis of constrained fused pyrazolones. These compounds are prepared in five to seven steps with a good overall yield from glycine methyl ester and commercial propanediol derivatives involving an intramolecular alkylation of a glycine moiety as key step. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. Source


Gembus V.,INSA Rouen | Janvier S.,Oril Industries | Lecouve J.-P.,Oril Industries | Vaysse-Ludot L.,Oril Industries | And 2 more authors.
Organic and Biomolecular Chemistry | Year: 2012

A concise synthetic route has been developed for the preparation of a constrained peptidomimetic pyrazinone building block. From hydroxy-l-lysine, the desired pyrazinone is obtained in 43% overall yield (6 steps) via an efficient deprotection-double cyclization sequence. © 2012 The Royal Society of Chemistry. Source

Discover hidden collaborations