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Bolbec, France

Maj A.M.,University of Lille Nord de France | Maj A.M.,Ecole Nationale Superieure de Chimie de Lille | Suisse I.,University of Lille Nord de France | Suisse I.,Lille University of Science and Technology | And 5 more authors.
Tetrahedron | Year: 2013

The asymmetric hydrogenation of a series of quinolines substituted by a variety of functionalized groups linked to the C2 carbon atom is providing access to optically enriched 2-functionalized 1,2,3,4-tetrahydroquinolines in the presence of in situ generated catalysts from [Ir(cod)Cl]2, a bisphosphine, and iodine. The enantioselectivity levels were as high as 96% ee. © 2013 Elsevier Ltd. All rights reserved. Source


Maj A.M.,University of Lille Nord de France | Maj A.M.,Ecole Nationale Superieure de Chimie de Lille | Suisse I.,University of Lille Nord de France | Suisse I.,University Lille1 science et Technologies | And 7 more authors.
Tetrahedron Letters | Year: 2012

The asymmetric hydrogenation of a new series of 2-functionalized quinolines has been developed in the presence of in situ generated catalysts obtained from [Ir(cod)Cl] 2/(R)-bisphosphine/I 2 combinations. The enantioselectivity levels were as high as 84-94% ee for the synthesis of 1,2,3,4-tetrahydroquinolines. © 2012 Elsevier B.V. All rights reserved. Source


Maj A.M.,University of Lille Nord de France | Maj A.M.,Ecole Nationale Superieure de Chimie de Lille | Suisse I.,University of Lille Nord de France | Suisse I.,Lille University of Science and Technology | And 5 more authors.
Comptes Rendus Chimie | Year: 2014

A chiral (R) key intermediate of the biologically active form of terutroban has been prepared by asymmetric hydrogenation. The catalysts are based on very easily accessible ruthenium complexes modified by chiral phosphorous ligands. The use of the chiral catASium®T ligands family allowed us to realize this transformation efficiently in terms of yield and enantioselectivity (ee up to 92%) with high substrate/catalyst ratios. © 2013 Académie des sciences. Source


Couvrat N.,University of Rouen | Martins D.,Minakem Recherche | Lafontaine A.,GSK | Sanselme M.,University of Rouen | And 5 more authors.
Chemical Engineering and Technology | Year: 2016

Strontium succinate, an active pharmaceutical ingredient against osteoporosis, exhibits two polymorphs related by a reversible order-disorder transformation at about 50°C. However, during the industrial crystallization process, the transition from the high-temperature form towards the low-temperature form was partially inhibited, leading to a mixture of phases at room temperature. The stressful character of the industrial process as demonstrated by in situ X-ray diffraction and Raman analyses led to defects, constraints, and a coarse mosaicity within crystals. Moreover, thermogravimetric analyses revealed that a non-negligible amount of water was trapped inside the crystalline solid. The combination of these two factors (stressful crystallization and trapped water) could be at the origin of the partial blockage of the transition. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Source


Maj A.M.,University of Lille Nord de France | Suisse I.,University of Lille Nord de France | Pinault N.,Oril Industrie | Robert N.,Oril Industrie | Agbossou-Niedercorn F.,University of Lille Nord de France
ChemCatChem | Year: 2014

The hydrogenation of N-unsubstituted cyclic imides to the corresponding cyclic amines has been performed selectively with heterogeneous catalysts obtained from rhodium and molybdenum carbonyl precursors. Various substrates were reduced in good to high yields and selectivities. Platinum-based catalysts also proved to be efficient. Furthermore, gram-scale experiments were performed and the catalysts could be recycled. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Source

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