Kim D.I.,Oriental Medicine Industry Support Center |
Kim K.S.,Kyungpook National University |
Kang J.H.,Kyungwoon University |
Kim H.J.,Kyungwoon University
Preventive Nutrition and Food Science | Year: 2013
In this study, we evaluated the hypolipidemic and antioxidative effects of biotransformed soybean powder (BTS; Phellinus baumii-fermented soybean) on lipid metabolism in rats. Sprague-Dawley (SD) male rats were divided into basal diet group (BA), high fat diet group (HF), high fat diet containing 10% BTS group (10 BTS), and high fat diet containing 20% BTS group (20 BTS). Changes in the content of various isoflavones, including daidzein and genistein, within the soybean after fermentation to BTS were investigated. The levels of daidzein and genistein were 149.28 μg/g and 364.31 μg/g, respectively. After six weeks experimental period, Food efficiency ratio in the 10 and 20 BTS group was significantly lower than the HF group (P<0.05). Total serum levels of cholesterol, triglycerides, low-density lipoprotein cholesterol, and atherogenic index ratio in the 10 or 20 BTS group were significantly lower than the HF group. The levels of alanine aminotransferase, aspartate aminotransferase and thiobarbituric acid reactive substance were significantly lower in the groups that received 10% and 20% BTS than the HF. The activities of SOD and CAT were significantly higher in the 10 and 20 BTS group than the HF group. The activity of XO in the 10 and 20 BTS group was significantly lower than in the HF group by 20% and 23%, respectively. In conclusion, these data suggest that BTS is an effective agent in improving lipid metabolism and antioxidant enzyme system. Copyright © 2013 by The Korean Society of Food Science and Nutrition. All rights Reserved.
Hong I.-H.,Gyeongsang National University |
Choi J.-Y.,Kyungpook National University |
Kim A.-Y.,Kyungpook National University |
Lee E.-M.,Kyungpook National University |
And 4 more authors.
Food and Agricultural Immunology | Year: 2016
Adlay (CL) has been used as food and medicinal plant, and its anti-inflammatory, anti-cancer and anti-allergic activities have been demonstrated. However, its anti-rheumatoid arthritic effect has not been evaluated. We evaluated the anti-rheumatoid arthritic activity of fermented CL (FCL) in vivo compared to fermented Achyranthes japonica Nakai (FAJN). The collagen-induced arthritis (CIA) mouse model was used, and clinical signs, histological examination, serum inflammatory and rheumatoid factors were analyzed. FCL and FAJN significantly reduced incidence of CIA, alleviated inflammation and joint destruction through inhibition of IL-1β and rheumatoid factors. In addition, they increased anti-oxidant enzyme activity such as superoxide dismutase (SOD) in the liver. Interestingly, ferulic acid was isolated from the FCL extract, which have anti-oxidant and anti-inflammatory activities. Moreover, the anti-rheumatoid arthritis (RA) effect of FCL was shown to be similar to or much better than that of FAJN. Therefore, our study suggests that FCL and FAJN are potential agents to alleviate RA. © 2016 Informa UK Limited, trading as Taylor & Francis Group
Kim H.-J.,Kyungwoon University |
Kim K.-S.,Kyungpook National University |
Kim D.-I.,Oriental Medicine Industry Support Center
Journal of the Korean Society of Food Science and Nutrition | Year: 2012
To investigate the inhibitory effects of Lespedeza cuneataextract (LC) on photo aging, skin aging was induced by UVB irradiation of hairless mice for 5 weeks. The skin erythema indices for the positive control (PC) and Lespedeza cuneata extract (LC-1%, 3%, and 5%) groups were lower than that of the control group. However, both lipid and water capacities of the PC and LC-3% groups were significantly higher than those of the control group. Skin wrinkles in the PC and LC-3% groups formed in a pattern of shallow furrows and thin crests. Skin TBARS contents and XO activity in the LC group were lower than those of the control group. The activities of GSH, SOD, and CAT in the LC-3% group were significant higher than those of the control group. Therefore, Lespedeza cuneata extract could be an effective natural herbal material for the inhibition of skin aging in hairless mice skin.
Kim D.-I.,Oriental Medicine Industry Support Center |
Kim H.-J.,Kyungwoon University
Journal of the Korean Society of Food Science and Nutrition | Year: 2014
The purpose of this study was to examine the skin regeneration ability of Lespedeza cuneata extract (LC) as well as verify its wound healing effects on an open wound in rats. Rats were divided into six groups (NO, saline treated group; CO, 1% carboxy methyl cellulose (CMC) treated group; PC, fucidin treated group; LCL, 1% LC treated group; LCM, 3% LC treated group; LCH, 5% LC treated group), and the experimental material was applied for 5 weeks. Elastase inhibition rate of the LCM group was 2.7% lower than that of butylated hydroxy anisole (BHA), which is an antioxidant. Futher, the collagenase inhibition rate of the LCM showed 7% higher activity than that of BHA. The left wound areas in the LCL group, LCM group, and LCH group after the 21st day were noticeably reduced in wound area by 54.2%, 53.5%, and 48.7%, respectively, compared to the CO group. This suggests that Lespedeza cuneata extract has healing effects on surgical wounds by promoting regeneration of skin epithelial tissue and synthesis of collagen.