Organic Chemistry Research Laboratory

Raigarh Fort, India

Organic Chemistry Research Laboratory

Raigarh Fort, India
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Survase D.,Organic Chemistry Research Laboratory | Bandgar B.,University of Solapur | Helavi V.,Organic Chemistry Research Laboratory
Synthetic Communications | Year: 2017

Synthesis of pyrimido[1,2-a]benzimidazole and pyrano[2,3-c]pyrazole derivatives were achieved using polyethylene glycol (PEG-400) as promoting reaction medium in water under catalyst-free conditions at reflux and room temperature, respectively. The structure of pyrimido[1,2-a]benzimidazole was confirmed using 1H NMR, 13C NMR, DEPT, and HMBC experiments. The promising points for the present methodology are efficiency, generality, high yield, short reaction time, cleaner reaction profile, ease of product isolation, simplicity, potential of recycling reaction medium, and finally agreement with green chemistry protocols. © 2017 Taylor & Francis.


Patil S.G.,Organic Chemistry Research Laboratory | Bhadke V.V.,Organic Chemistry Research Laboratory | Bagul R.R.,Organic Chemistry Research Laboratory
Journal of Chemical and Pharmaceutical Research | Year: 2012

Basic ionic liquid catalyzed synthesis of various pyrazolo [3, 4-b] pyridines were synthesized by cyclocondensation of 5-amino-3 aryl -1-H phenylpyrazoles, p-substituted benzoylacetonitriles and some aryl aldehydes by using basic ionic liquid, [bmIm]OH. It acts as a base catalyst. Comparative study of triethylamine and [bmIm]OH. and ammonium acetate was studied.Reusability of catalyst with good yields under green reaction conditions is the salient feature of this synthetic method.


In the present study three new imidazole derivatives of phen, 2-(4-hydroxy-3,5-diiodophenyl) imidazo[4,5-f][1,10]phenanthroline L1, 2-(2-hydroxy-3,5-diiodophenyl)imidazo[4,5-f][1,10]phenanthroline L2, 2-(4-hydroxy-5-iodo-3-methoxyphenyl)imidazo[4,5-f][1,10]phenanthroline L3 and their nine new polypyridine complexes[M(N-N)2(L1-3)](OAc)2·(nH2O) where M is Ni(II), Co(II) and Cu(II) and where (N-N)2 is 2,2'-bipyridine (bpy)2 or 1,10-phenanthroline (phen)2 have been synthesized from the reaction of the metal precursor complexes [M(phen)2(OAc)2]·(nH2O) and [M(bpy)2(OAc)2]·(nH2O) with the respective ligands in ethanol and water. The structures of the compounds were determined with the aid of elemental analysis and FT-IR, UV-Vis, 1H NMR, ESR spectroscopic methods, magnetic measurements and conductance measurements, further analyzed by powder XRD and thermal studies. Elemental analysis data suggested that the complexes have a 1:2:1 molar ratio among the metal and phen or bpy and L1/L2 or L3 ligands. The spectral data show that all the complexes were six coordinated and possess octahedral geometry around the metal ions. The X-band ESR spectrum of the Cu(II) in DMSO solution at room temperature was recorded and observed anisotropic g values indicate the presence of metal ion in an octahedral environment. The powder XRD patterns of complexes recorded in the range (2θ =0-80°) and average crystallite size (d XRD) was calculated using Scherrer's formula. Thermal decomposition profiles of complexes show high decompound temperatures indicating a good thermal stability. Binding of the complexes with calf thymus DNA (CT DNA) has been investigated by gel electrophoresis. The experimental results indicate that the complexes bind to DNA by intercalation mode and found to promote cleavage of plasmid pBR 322 DNA from the supercoiled form I to the open circular form II upon irradiation. © 2015 The Authors.


Khan A.J.,Milliya College | Baseer M.A.,Organic Chemistry Research Laboratory
Oriental Journal of Chemistry | Year: 2011

Simple and convenient procedure have been developed for the synthesis of optically active1,5-benzothiazepine derivatives by reaction of 2-aminothiophenol with newly synthesized Chalcones under mild conditions in the presence of catalytic amount of Lanthanum Nitrate in short reaction time with excellent yield(75-80%)The products were tested for purity by TLC and characterized by MP, IR and 1H NMR spectral studies.


Baseer M.A.,Organic Chemistry Research Laboratory | Khan A.J.,Milliya College
E-Journal of Chemistry | Year: 2012

2,3-Dihydro-1H-1,5-benzodiazepines were synthesized by reaction of o-phenylenediamine with ketones (acyclic / cyclic) under solvent free conditions in the presence of tetra butyl ammonium bromide (TBAB) in short reaction time with excellent yield.


Shah P.,Institute of Chemical Technology | Santana M.D.,University of Murcia | Garcia J.,University of Murcia | Serrano J.L.,Technical University of Cartagena | And 3 more authors.
Tetrahedron | Year: 2013

The potential of complex [Pd(PPh3)2(saccharinate) 2] 1 in catalyzing Suzuki-Miyaura cross-coupling of 4-halo and 4-bromomethyl coumaryl and pyrone substrates with different aryl boronic acids has been explored. Excellent yields of the desired products are obtained in competitive reaction time and under relatively mild conditions. Negishi cross-coupling of 4-coumaryl tosylate with aryl and alkylzinc reagents has also been performed with good yields of the cross-coupled products obtained in most cases. Intra-molecular C-H bond functionalization of coumaryl ethers also furnished very high yields of synthetically attractive tetracyclic ring systems exhibiting the potential of 1 as a powerful catalyst in synthetically important reactions. © 2012 Published by Elsevier Ltd.


Kendre M.M.,Organic Chemistry Research Laboratory | Baseer M.A.,Organic Chemistry Research Laboratory
Oriental Journal of Chemistry | Year: 2013

Biologically active Pyrazoline derivatives were efficiently synthesized in excellent yields and in less reaction time using ethanol via cyclization reaction of chalcones and hydrazine hydrate. These newly synthesized compounds were screened for their antimicrobial potencies which reflects moderate to good activity against different strains of bacteria and fungi employed. All the synthesized compounds were confirmed by IR, 1HNMR and Mass spectral data.


Patil V.D.,Organic Chemistry Research Laboratory | Dere G.B.,Organic Chemistry Research Laboratory | Rege P.A.,Organic Chemistry Research Laboratory | Patil J.J.,Organic Chemistry Research Laboratory
Synthetic Communications | Year: 2011

Efficient synthesis of bis(indolyl) methanes by the reaction of indoles with various carbonyl compounds in the absence of catalyst and solvent afforded the corresponding bis(indolyl) methanes in excellent yields. © 2011 Taylor & Francis Group LLC.


Meshram G.A.,Organic Chemistry Research Laboratory | Patil V.D.,Organic Chemistry Research Laboratory
Synthetic Communications | Year: 2010

A simple and efficient synthesis of bis(indolyl) methanes by the reaction of indoles with various carbonyl compounds in the presence of a catalytic amount of cupric fluoroborate [Cu(BF4)2SiO2] afforded the corresponding bis(indolyl) methanes in excellent yields. The remarkable selectivity under mild and neutral conditions and commercially available, inexpensive catalyst are attractive features of this method. © 2009 Taylor & Francis Group, LLC.


Pednekar S.,Organic Chemistry Research Laboratory | Bhalerao R.,Organic Chemistry Research Laboratory | Ghadge N.,Organic Chemistry Research Laboratory
Journal of Chemical Sciences | Year: 2013

An efficient protocol for the synthesis of differently substituted 1, 4-dihydropyridines in deep eutectic solvents under solvent-free conditions is reported here. Excellent yields of the resultant products have been obtained. Recyclability studies have also been performed for deep eutectic solvents with very little loss in activity up to five recycles. [Figure not available: see fulltext.] © 2013 Indian Academy of Sciences.

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