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Khan A.J.,Milliya College | Baseer M.A.,Organic Chemistry Research Laboratory
Oriental Journal of Chemistry | Year: 2011

Simple and convenient procedure have been developed for the synthesis of optically active1,5-benzothiazepine derivatives by reaction of 2-aminothiophenol with newly synthesized Chalcones under mild conditions in the presence of catalytic amount of Lanthanum Nitrate in short reaction time with excellent yield(75-80%)The products were tested for purity by TLC and characterized by MP, IR and 1H NMR spectral studies. Source


Baseer M.A.,Organic Chemistry Research Laboratory | Khan A.J.,Milliya College
E-Journal of Chemistry | Year: 2012

2,3-Dihydro-1H-1,5-benzodiazepines were synthesized by reaction of o-phenylenediamine with ketones (acyclic / cyclic) under solvent free conditions in the presence of tetra butyl ammonium bromide (TBAB) in short reaction time with excellent yield. Source


In the present study three new imidazole derivatives of phen, 2-(4-hydroxy-3,5-diiodophenyl) imidazo[4,5-f][1,10]phenanthroline L1, 2-(2-hydroxy-3,5-diiodophenyl)imidazo[4,5-f][1,10]phenanthroline L2, 2-(4-hydroxy-5-iodo-3-methoxyphenyl)imidazo[4,5-f][1,10]phenanthroline L3 and their nine new polypyridine complexes[M(N-N)2(L1-3)](OAc)2·(nH2O) where M is Ni(II), Co(II) and Cu(II) and where (N-N)2 is 2,2'-bipyridine (bpy)2 or 1,10-phenanthroline (phen)2 have been synthesized from the reaction of the metal precursor complexes [M(phen)2(OAc)2]·(nH2O) and [M(bpy)2(OAc)2]·(nH2O) with the respective ligands in ethanol and water. The structures of the compounds were determined with the aid of elemental analysis and FT-IR, UV-Vis, 1H NMR, ESR spectroscopic methods, magnetic measurements and conductance measurements, further analyzed by powder XRD and thermal studies. Elemental analysis data suggested that the complexes have a 1:2:1 molar ratio among the metal and phen or bpy and L1/L2 or L3 ligands. The spectral data show that all the complexes were six coordinated and possess octahedral geometry around the metal ions. The X-band ESR spectrum of the Cu(II) in DMSO solution at room temperature was recorded and observed anisotropic g values indicate the presence of metal ion in an octahedral environment. The powder XRD patterns of complexes recorded in the range (2θ =0-80°) and average crystallite size (d XRD) was calculated using Scherrer's formula. Thermal decomposition profiles of complexes show high decompound temperatures indicating a good thermal stability. Binding of the complexes with calf thymus DNA (CT DNA) has been investigated by gel electrophoresis. The experimental results indicate that the complexes bind to DNA by intercalation mode and found to promote cleavage of plasmid pBR 322 DNA from the supercoiled form I to the open circular form II upon irradiation. © 2015 The Authors. Source


Patil V.D.,Organic Chemistry Research Laboratory | Patil K.P.,Organic Chemistry Research Laboratory
International Journal of ChemTech Research | Year: 2015

Nickel acet a te efficiently catalyzed the synthesis of benzimidazole and benzoxazole derivatives. This method has been applied to a variety of substrates including nucleophilic and sterically hindered diamines, aldehyde and phenol with excellent yields of benzimidazole and benzoxazole derivatives. The remarkable selectivity under mild and neutral conditions of this commercially available inexpensive catalyst is an attractive feature of this present protocol. © 2015, Sphinx Knowledge House. All rights reserved. Source


Kendre M.M.,Organic Chemistry Research Laboratory | Baseer M.A.,Organic Chemistry Research Laboratory
Oriental Journal of Chemistry | Year: 2013

Biologically active Pyrazoline derivatives were efficiently synthesized in excellent yields and in less reaction time using ethanol via cyclization reaction of chalcones and hydrazine hydrate. These newly synthesized compounds were screened for their antimicrobial potencies which reflects moderate to good activity against different strains of bacteria and fungi employed. All the synthesized compounds were confirmed by IR, 1HNMR and Mass spectral data. Source

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