Organic Chemistry Research Center

Nashik, India

Organic Chemistry Research Center

Nashik, India
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Deshmukh G.B.,Organic Chemistry Research Center | Patil N.S.,Organic Chemistry Research Center | Gaikwad V.B.,Organic Chemistry Research Center | Bhole A.D.,P.A. College | Patil S.V.,Organic Chemistry Research Center
Journal of Chemical and Pharmaceutical Research | Year: 2014

Substituted N-Aryl Pyrollo-Quinolines was achieved by the reductive isomerisation of (E)-3-(2-nitrobenzylidene)-1- phenylpyrrolidine-2, 5-dione with iron in acetic acid and studied for their biological activity. © 2014, Journal of Chemical and Pharmaceutical Research. All rights reserved.


Deshmukh S.V.,Organic Chemistry Research Center | Rane B.S.,Organic Chemistry Research Center | Ghagare M.G.,Organic Chemistry Research Center | Gaikwad V.B.,Organic Chemistry Research Center | And 2 more authors.
Journal of Chemical and Pharmaceutical Research | Year: 2014

N-alkylated Pyrazolopyridines was achieved by the reaction of pyrazolo-pyridines with different anilides in basic media and studied for their biological activity.


Rane B.S.,Organic Chemistry Research Center | Deshmukh S.V.,Organic Chemistry Research Center | Ghagare M.G.,Organic Chemistry Research Center | Rote R.V.,Organic Chemistry Research Center | Jachak M.N.,Organic Chemistry Research Center
Journal of Chemical and Pharmaceutical Research | Year: 2012

Spiro-pyrimido [4,5-b]quinoline was synthesized by condensation of 2-aminoquinoline-3-carboxamide with cyclic ketone in presence of zinc chloride and studied for their biological activity.


Chikhalikar S.,Bharatiya Vidya Bhavans Nm Institute Of Science | Bhawe V.,Bharatiya Vidya Bhavans Nm Institute Of Science | Ghotekar B.,Organic Chemistry Research Center | Jachak M.,Organic Chemistry Research Center | Ghagare M.,Organic Chemistry Research Center
Journal of Organic Chemistry | Year: 2011

The nucleophilic vinylic substitution reaction of the aliphatic enaminone 3-dimethylamino-2-formyl acrylonitrile 1 with the nucleophiles malononitrile and ethyl cyanoacetate produced the two unusual reaction adducts 3a and 3b in good to moderate yield under milder reaction conditions. Upon reaction with aromatic amines, these adducts yielded enamines 4 and 5, which eventually cyclized in the presence of base to produce the novel pyridin-2(1H)-one derivatives 8 and 9. © 2011 American Chemical Society.


Chikhalikar S.,Bharatiya Vidya Bhavans Nm Institute Of Science | Bhawe V.,Bharatiya Vidya Bhavans Nm Institute Of Science | Jachak M.,Organic Chemistry Research Center | Ghagare M.,Organic Chemistry Research Center
European Journal of Organic Chemistry | Year: 2011

Two alternative methods for the synthesis of biologically important pyridin-2(1H)-one derivatives have been developed. The behavior of enamine 1 with aromatic amines in an aqueous solution of HCl resulted in the formation of substituted enamines 2a-f at ambient temperature. The obtained product enamines 2a-f, upon treatment with 2,2,6-trimethyl-4H-1,3-dioxin-4-one, generated pyridin-2(1H)-one derivatives 5a-f along with the unwanted side products 8a-f. However, the exclusive formation of pyridin-2(1H)-one derivatives 5a-f was achieved when starting from β-enaminones 3a-f, which were synthesized successfully from enamine 1 and aromatic amines at elevated temperatures. Compounds 2 and 3 have been used as precursors in the synthesis of pyridin-2(1H)-one derivatives. Temperature-dependent reaction diversity was observed for enamine 1 and the exclusive formation of pyridin-2(1H)-one derivatives 5 was possible. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


Rane B.S.,Organic Chemistry Research Center | Kazi M.A.,Organic Chemistry Research Center | Bagul S.M.,Organic Chemistry Research Center | Shelar D.P.,Organic Chemistry Research Center | And 2 more authors.
Journal of Fluorescence | Year: 2010

A convenient route was successfully developed for the synthesis of novel heterocycles such as spiro-oxazino-quinoline derivatives from 2-aminoquinoline-3-carbonitrile (4) in good yield. The Spiro-quinoline derivatives (6, 8 and 10) were synthesized and further studied for their photophysical properties. Semiempirical molecular orbital calculation (PM3/PM6 for structure) proves to be a suitable tool for the prediction of absorption and fluorescence properties of these compounds. © 2009 Springer Science+Business Media, LLC.


Shelar D.P.,Organic Chemistry Research Center | Birari D.R.,Organic Chemistry Research Center | Rote R.V.,Organic Chemistry Research Center | Patil S.R.,Organic Chemistry Research Center | And 2 more authors.
Journal of Physical Organic Chemistry | Year: 2011

A novel route was successfully developed for the synthesis of new synthons, orthoamino formyl quinoline (heterocyclic orthoaminoaldehyde) and utilized for the synthesis of series of benzonaphthyridines by Friedländer condensation reactions with benzoylacetonitrile. The benzonaphthyridines synthesized were further studied for their fluorescence properties. Copyright © 2010 John Wiley & Sons, Ltd.


Shinde G.B.,A.P.Pharma | Niphade N.C.,A.P.Pharma | Deshmukh S.P.,A.P.Pharma | Toche R.B.,Organic Chemistry Research Center | Mathad V.T.,A.P.Pharma
Organic Process Research and Development | Year: 2011

Described is a new, practical, and one-pot process, based on the Forster reaction, for the synthesis of cinacalcet hydrochloride (1), a calcimimetic agent and calcium-sensing receptor antagonist. The synthesis comprises the condensation of (1R)-(+)-1-naphthylethyl amine (2) with benzaldehyde (3) followed by reaction of obtained Schiff's base 4 with 1-(3-halopropyl)-3- (trifluoromethyl)benzene (5) to provide highly unstable iminium salt 6. Subsequent hydrolysis of 6 with water in the same pot yielded cinacalcet. The treatment of cinacalcet with hydrochloric acid during the workup process furnished 1 with an overall yield of around 60%. Our synthetic approach for 1, discussed in this report demonstrates industrial application of the century-old, unexplored name reaction, "Forster's Reaction" or Forster-Decker synthesis. © 2011 American Chemical Society.


Ghotekar B.K.,Organic Chemistry Research Center | Ghagare M.G.,Organic Chemistry Research Center | Toche R.B.,Organic Chemistry Research Center | Jachak M.N.,Organic Chemistry Research Center
Monatshefte fur Chemie | Year: 2010

Synthesis of novel benzo[h]-1,6-naphthyridines was successfully achieved by cyclocondensation of ethyl 4-aminoquinoline-3-carboxylates with malononitrile. The pyrazolo[4,3-c]quinolines were synthesized by nucleophilic substitution and subsequent addition reaction of ethyl 4-chloroquinoline-3-carboxylates with different hydrazines. All new compounds were characterized by spectral and analytical methods. © Springer-Verlag 2010.


Toche R.B.,Organic Chemistry Research Center | Chavan S.N.,Organic Chemistry Research Center
Journal of Fluorescence | Year: 2014

4-Hetero-1-yl-2-bromothieno[3,2-c]pyridines 3(a-d) were synthesized by the reaction of 2-bromo-4-chlorothieno[3,2-c]pyridine (1) and cyclic amine 2(a-d), which on Suzuki coupling with substituted boronic acids 4(a-f) exclusively converted to corresponding 4-hetero -1-yl-2-arylthieno[3,2-c]pyridine 5(a-x) in good yields. The effect of donor-acceptor substituent on absorption emission properties and fluorescent quantum yield of new thienopyridine derivatives 5(a-x) were studied. © 2013 Springer Science+Business Media New York.

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