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Pintilie L.,Romanian National Institute for Chemical Pharmaceutical Research and Development | Nita S.,Romanian National Institute for Chemical Pharmaceutical Research and Development | Caproiu M.T.,Organic Chemistry Center Cdnenitescu
Revista de Chimie | Year: 2010

This paper presents experimental data regarding the synthesis of several 7-chloro-8-substituted-l,4-dihydro-4-oxo-quinolin-3-carboxylic acids, without a fluorine atom in 6-position by Gould-Jacobs cyclization. These novel compounds have been analised by physico - chemical technics (elemental analisys, 1H-NMR, 13C-NMR,FTIR, thin layer chromatography). Source


Tanase C.,Romanian National Institute for Chemical Pharmaceutical Research and Development | Negut C.C.,Romanian National Institute for Chemical Pharmaceutical Research and Development | Negut C.C.,Polytechnic University of Bucharest | Udeanu D.I.,Carol Davila University of Medicine and Pharmacy | And 6 more authors.
Revista de Chimie | Year: 2014

This paper presents the synthesis, physico-chemical characterization and preliminary pharmacological study of some oleamide analogues. Their synthesis was realized by basic amidation of methyl oleate with phenylalaninol and phenethylamine and by direct amidation of oleic acid with 1-naphthylamine and cyclohexylamine in the presence of I, V-carbonildiimidazole. The oleamide analogues were fully characterized by IR, MS, 1H-and 13C-NMR spectra. The compounds were investigated for the influence on bodyweight and food intake effects. Source


Visinescu D.,Ilie Murgulescu Institute of Physical Chemistry | Scurtu M.,Ilie Murgulescu Institute of Physical Chemistry | Negrea R.,National Institute of Materials Physics Bucharest | Birjega R.,Romanian National Institute for Lasers, Plasma and Radiation Physics | And 7 more authors.
RSC Advances | Year: 2015

A family of mesoporous, self-aggregated zinc oxide materials with spherical morphologies of high crystalline quality, is obtained through a facile, additive-free polyol procedure. The forced hydrolysis of zinc acetylacetonate in 1,4-butanediol (BD), in various reaction conditions, affords ZnO materials with versatile morphologies and optical properties. The reaction parameters (temperature, time and zinc source concentration) modulate the ZnO nanocrystallites size (from 8.1 to 13.2 nm), the spheres diameter (ranging from 50 up to 250 nm), the internal structure of the spherical aggregates (hollow or solid) and their specific surface area (from 31 to 92 m2 g-1). Polycrystalline spheres with hollow cores are obtained at the lowest temperature (90 °C) and zinc cation concentration (0.1 M), while at higher reaction temperatures (140-180 °C), solid spherical aggregates are developed. A reaction mechanism for ZnO formation via zinc layered hydroxide (LDH-Zn) is proposed based on nuclear magnetic resonance (1H NMR and 13C NMR) and powder X-ray diffraction (XRD) studies. The obtained ZnO materials have a functionalized surface, derived from the polyol and act as a nitrogen selective photocatalyst in the reduction reaction of NO3 -. The organic residual attached on the ZnO surface plays a crucial role in the denitrification reaction, since the photo-cleaned sample showed negligible photocatalytic activity. The ZnO materials also exhibited microbicidal and anti-biofilm activity against reference and clinical strains, highlighting their potential for the development of novel antimicrobial formulations. © The Royal Society of Chemistry 2015. Source


Tanase C.I.,Romanian National Institute for Chemical Pharmaceutical Research and Development | Draghici C.,Organic Chemistry Center Cdnenitescu | Caproiu M.T.,Organic Chemistry Center Cdnenitescu | Shova S.,Petru Poni Institute of Macromolecular Chemistry | And 4 more authors.
Bioorganic and Medicinal Chemistry | Year: 2014

An amine group was synthesized starting from an optically active bicyclo[2.2.1]heptane compound, which was then used to build the 5 atoms ring of a key 6-chloropurine intermediate. This was then reacted with ammonia and selected amines obtaining new adenine- and 6-substituted adenine conformationally constrained carbocyclic nucleoside analogues with a bicyclo[2.2.1]heptane skeleton in the sugar moiety. X-ray crystallography confirmed an exo-coupling of base to the ring and a L configuration of the nucleoside analogues. The compounds were tested for anticancer activity. © 2013 Published by Elsevier Ltd. All rights reserved. Source


Tnase C.I.,Romanian National Institute for Chemical Pharmaceutical Research and Development | Drghici C.,Organic Chemistry Center Cdnenitescu | Cojocaru A.,Romanian National Institute for Chemical Pharmaceutical Research and Development | Galochkina A.V.,Influenza Research Institute | And 5 more authors.
Bioorganic and Medicinal Chemistry | Year: 2015

New nucleoside analogues with an optically active bicyclo[2.2.1]heptane skeleton as sugar moiety and 6-substituted adenine were synthesized by alkylation of 6-chloropurine intermediate. Thymine and uracil analogs were synthesized by building the pyrimidine ring on amine 1. X-ray crystallography confirmed an exo-coupling of the thymine to the ring and an L configuration of the nucleoside analogue. The library of compounds was tested for their inhibitory activity against influenza virus A\-California/07/09 (H1N1)pdm09 and coxsackievirus B4 in cell culture. Compounds 13a and 13d are the most promising for their antiviral activity against influenza, and compound 3c against coxsackievirus B4. Compounds 3b and 3g were tested for anticancer activity. © 2015 Elsevier Ltd. Source

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