Organic Chemistry Center Cd Nenitescu

Bucharest, Romania

Organic Chemistry Center Cd Nenitescu

Bucharest, Romania

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Tanase C.,Romanian National Institute for Chemical Pharmaceutical Research and Development | Cocu F.G.,Romanian National Institute for Chemical Pharmaceutical Research and Development | Caproiu M.T.,Organic Chemistry Center Cd Nenitescu | Draghici C.,Organic Chemistry Center Cd Nenitescu | And 2 more authors.
Revue Roumaine de Chimie | Year: 2011

Synthesis of new nucleosides with an oxabiciclo[3.3.0]octane fragment in the sugar moiety was performed by Vorbruggen nucleoside synthesis with silylated pyrimidine bases: 5-FU, 5-ClU, 5-BrU, C and 6-aza-U. The compounds were characterized by IR, MS, 1H-NMR and 13C-NMR spectra and tested for their antitumor activity comparatively with U-34 and 5IU-34. Our study points out that Cl-U-34, Br-U-34 and I-U-34 might be more efficient than U-34 against the multiplication of cancer cells, like Jurkat T lymphoblasts.


Tanase C.I.,Romanian National Institute for Chemical Pharmaceutical Research and Development | Draghici C.,Organic Chemistry Center Cd Nenitescu | Caproiu M.T.,Organic Chemistry Center Cd Nenitescu | Pintiue L.,Romanian National Institute for Chemical Pharmaceutical Research and Development | And 2 more authors.
Revista de Chimie | Year: 2014

The Grignard reaction of 2-bromomagnesium ethanol-TBDMS-ether 3 with the ketone: ((1S,2S,4S,7R)-2-Chloro-5-oxobicyclo[2.2.1]heptan-7-yl)methyl methanesulfonate, 5, gave no addition to the ketone group. Instead, the basicity of organomagnesium compound 3 induce a dehydrochlorination followed by substitution of the mesyl group with bromide to the tricyclic compound 9. The intermediate bromide 8, resulted from substitution of the mesyl group of the starting compound 5, was also isolated. The oximes, acetylated oximes and 2,4-dinitrophenyl-hydrazone of compound 9 were also synthesized to characterize the final product.

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