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News Article | March 31, 2016
Site: techcrunch.com

Juicero.com, a food tech startup that makes Internet-connected kitchen appliances, raised $70 million in Series B funding in a round led by Artis Ventures. Juicero’s flagship product is a $699 countertop device that cold presses juice out of “packs” of already prepped fruit and veggies. The packs — reminiscent of the cups and pouches used in single-cup coffee brewers from Keurig, Flavia or Nespresso — cost $4 to $10 each and are available through a Juicero subscription, but not in groceries. Not yet anyway. The Juicero is selling in California only. Companies are increasingly building hardware with the aim of generating recurring sales through it, from Amazon Echo, to the Samsung Family Hub refrigerator or the smart feeders from Petnet.io. Juicero’s packs include a QR code, which allows the company to track data about how much juice someone is making and which recipes they favor. The company’s app will suggest different recipes to try, or really pouches to buy, to round out a customer’s nutrition. The idea is to get people to drink their fruit- and vegetable-based nutrients and reduce the amount of junk foods that they buy and eat, while also making it easy to cold-press juice at home or possibly the office. Founded by Organic Avenue co-founder Doug Evans, Juicero also promises to use produce that’s organic and skip the processing required by even the most eco-conscious, bottled juice or smoothie brands. Other makers of high-end countertop juicers and blenders for home use, like Kuvings, Cuisinart or Vita-Mix Corp., aren’t offering these types of devices yet. But such appliance makers have been touting the benefits of liquid lunches of a non-alcoholic variety for decades, despite the naturally high sugar content of juices. The latest trend in the U.S. juice market is toward premium and cold-pressed juices, according to reports from food industry tracker Euromonitor International. Makers of bottled cold-pressed juices, such as Suja Life and Urban Remedy, have attracted venture capital in recent quarters, too. However, nutrition is complicated, and it’s not quite clear that standalone machines to make cold-pressed juices can deliver better health than bottled juices, or simply including a good amount of whole fruits and vegetables in a balanced diet. Artis Ventures’ co-founder and Senior Partner Mike Harden said his firm led the Series B investment in Juicero largely because of the quality and design of its hardware. But he also believes Juicero could have a big impact on its customers’ health. Juicero’s inventory tracking data can also help organic farmers predict demand and plant accordingly, he said. Alongside Artis Ventures, Juicero’s Series A and B investors included Kleiner Perkins Caufield & Byers, GV (formerly Google Ventures), Thrive Capital, Campbell Soup Company, Two Sigma Ventures, DBL Partners, First Beverage Group, Acre Venture Partners and others.


Recent consumer trends have shown a rising inclination toward healthier foods and beverages, notes Transparency Market Research. In a report titled “Cold Pressed Juice Market - Global Industry Analysis, Size, Share, Growth, Trends, and Forecast 2016–2024”, TMR offers a detailed analysis of the overall market and provides sharp actionable insights into what drivers and hampers its growth. Canada is a prominent market for cold pressed juices thanks to a growing number of consumers making healthier food choices. Looking to avoid various lifestyle diseases and pay more attention to their overall health and wellness, consumers have been reaping the benefits of nutrient-rich, high quality, plant and fruit-based beverages. Capitalizing on this trend are most companies in the country. A case in point would be Canada-based Jusu Bars Inc., which acquired another local company Cru Juice Inc. in September 2016. Jusu is on an acquiring spree and is reportedly not only the biggest but the most influential player in the cold pressed juice market in Canada. The cold pressed juice market in the U.S., like the overall juice market, benefits from the expansion of the organized retail industry. The growing availability of fruit and vegetable juices and juice products can be attributed to the variety of retail stores in the country, such as hypermarkets, supermarkets, and pop-up stores. A strong online sales and distribution channel also contributes to the development of the cold pressed juice market. In a country like India, where a massive urban youth population, growing disposable incomes, and a historical success of start-ups plays a key role in most markets, cold pressed juices have caught the eye of many companies. RAW Pressery is one such firm that has managed to establish a name for itself in the country for the last three years. The first quarter of 2016 saw the entry of beverage giant PepsiCo in the immensely potential cold pressed juice market. Under the brand name Naked Juice, the company tested its line of cold pressed juices at a rather competitive price and at most retailers in the U.S. West Coast. Moves such as these have been ensuring the future success of the cold pressed juices market. Some of the prominent names in the cold pressed juice market are Organic Press Juices, Pressed Juicery, Evergreen Juices Inc., JustPressed, Juice Generation, Organic Avenue, PepsiCo Inc., Hain BluePrint, Inc., Evolution Fresh, Liquiteria, and Suja Life, LLC. These player have been profiled in the report on the cold pressed juice market, highlighting their strengths and weaknesses in order to assess the threats and opportunities that are in store for them. Analysts have also shed light on key aspects such as company and business overview, financial standing, product portfolio, business strategies, and recent developments. Transparency Market Research (TMR) is a global market intelligence company providing business information reports and services. The company’s exclusive blend of quantitative forecasting and trend analysis provides forward-looking insight for thousands of decision makers. TMR’s experienced team of analysts, researchers, and consultants use proprietary data sources and various tools and techniques to gather and analyze information.


Fesenko A.A.,Organic Avenue | Trafimova L.A.,Organic Avenue | Shutalev A.D.,Organic Avenue
Organic and Biomolecular Chemistry | Year: 2012

A general approach to 6-phenylthio-substituted 2,3,4,5-tetrahydro-1H-1,3- diazepin-2-ones based on the ring expansion reaction of 1,2,3,4- tetrahydropyrimidin-2-ones under the action of nucleophiles has been developed. The first step of the synthesis was preparation of N-[(2-benzoyloxy-1-tosyl) ethyl]urea by three-component condensation of 2-benzoyloxyethanal, urea and p-toluenesulfinic acid. Nucleophilic substitution of the tosyl group in the obtained sulfone with sodium enolates of α-phenylthioketones followed by cyclization-dehydration, and debenzoylation gave 4-hydroxymethyl-5-phenylthio-1, 2,3,4-tetrahydropyrimidin-2-ones which were transformed into the 4-mesyloxymethyl-derivatives. Treatment of the latter with nucleophilic reagents, such as NaCN, sodium diethyl malonate, PhSNa, MeONa, NaBH 4, sodium succinimide, or potassium phthalimide, afforded the target multi-functionalized diazepinones. The obtained 6-phenylthio-diazepinones and their 6-tosyl-substituted analogues were converted into 3-substituted 1-carbamoyl-1H-pyrroles under acidic conditions as a result of ring contraction. Effective one-pot synthesis of the latter from 4-mesyloxymethyl-pyrimidines was realized using a ring expansion/ring contraction sequence. © 2012 The Royal Society of Chemistry.


Fesenko A.A.,Organic Avenue | Solovyev P.A.,Organic Avenue | Shutalev A.D.,Organic Avenue
Tetrahedron | Year: 2010

A novel four-step methodology for the synthesis of 5-acyl-1,2-dihydropyrimidin-2-ones has been developed. The reaction of readily available N-[(1-acetoxy-2,2,2-trichloro)ethyl]ureas with Na-enolates of 1,3-diketones or β-oxoesters followed by heterocyclization-dehydration of the oxoalkylureas formed gave 5-acyl-4-trichloromethyl-1,2,3,4-tetrahydropyrimidin-2-ones. The latter, in the presence of NaH, eliminate CHCl3 to give the target compounds. © 2009 Elsevier Ltd. All rights reserved.


A four-step method for the synthesis of 5-arylsulfonyl-substituted 1,2-dihydropyrimidin-2-ones has been developed. The reaction of readily available N-[(1-acetoxy-2,2,2-trichloro)ethyl]ureas with sodium enolates of α-arylsulfonylketones followed by heterocyclization-dehydration of the oxoalkylureas formed gave 5-arylsulfonyl-4-trichloromethyl-1,2,3,4- tetrahydropyrimidin-2-ones. The latter, in the presence of strong bases, eliminate CHCl3 to give the target compounds. © 2010 Elsevier Ltd.


Landelle G.,Organic Avenue | Bergeron M.,Organic Avenue | Turcotte-Savard M.-O.,Organic Avenue | Paquin J.-F.,Organic Avenue
Chemical Society Reviews | Year: 2011

Monofluoroalkenes are an important fluorinated class of compounds with applications in medicinal chemistry, material sciences and organic chemistry. An overview of methods allowing synthetic access to these fluorinated building blocks is provided. In particular, this critical review, which covers publications up to October 2010, will be divided according to the substitution pattern of the monofluoroalkenes, i.e. di-, tri- or tetra-substituted. Within each group, the various synthetic approaches will be divided according to the reaction type (282 references). © 2011 The Royal Society of Chemistry.


Vanderlinden W.,Laboratory of Photochemistry and Spectroscopy | Blunt M.,Laboratory of Photochemistry and Spectroscopy | David C.C.,Laboratory of Photochemistry and Spectroscopy | Moucheron C.,Organic Avenue | And 2 more authors.
Journal of the American Chemical Society | Year: 2012

We used scanning force microscopy (SFM) to study the binding and excited state reactions of the intercalating photoreagent Ru[(TAP)2PHEHAT] 2+ (TAP = 1,4,5,8-tetraazaphenanthrene; PHEHAT = 1,10- phenanthrolino[5,6-b]1,4,5,8,9,12-hexaazatriphenylene) with DNA. In the ground state, this ruthenium complex combines a strong intercalative binding mode via the PHEHAT ligand, with TAP-mediated hydrogen bonding capabilities. After visible irradiation, SFM imaging of the photoproducts revealed both the structural implications of photocleavages and photoadduct formation. It is found that the rate of photocleaving is strongly increased when the complex can interact with DNA via hydrogen bonding. We demonstrated that the photoadduct increases DNA rigidity, and that the photo-biadduct can crosslink two separate DNA segments in supercoiled DNA. These mechanical and topological effects might have important implications in future therapeutic applications of this type of compounds. © 2012 American Chemical Society.


A five-step synthesis of 4-chloromethyl- and 4-mesyloxymethyl-5-tosyl-1,2, 3,4-tetrahydropyrimidin-2-ones has been developed. The reaction of N-[(2-benzoyloxy-1-tosyl)ethyl]urea with sodium enolates of α-tosylketones followed by cyclization-dehydration, and debenzoylation gave 4-hydroxymethyl-5-tosyl-1,2,3,4-tetrahydropyrimidin-2-ones, which were transformed into the 4-chloromethyl- or 4-mesyloxymethyl-derivatives. Treatment of the latter with nucleophilic reagents, such as sodium cyanide, sodium diethyl malonate, sodium thiophenolate, or potassium phthalimide, afforded the corresponding 4,7-disubstituted 6-tosyl-2,3,4,5-tetrahydro-1H-1,3-diazepin-2- ones as a result of ring expansion. The effect of the leaving group and the substitution at the position C6 on the reactivity of the pyrimidines is discussed. © 2011 Elsevier Ltd. All rights reserved.


Rouchaud A.,Organic Avenue | Braekman J.-C.,Organic Avenue
European Journal of Organic Chemistry | Year: 2011

When diethyl malonate was added to a solution of Δ 1- piperideine, generated in situ by oxidative desamination and decarboxylation of L-lysine by N-bromosuccinimide (NBS), formation of the unexpected tricyclic compound 6 (4-diethylmalonyl-octahydro-4H-pyrrolo[1,2-c]pyrido[1′, 2′-a]imidazole)was observed. The structure of 6 was deduced from analysis of its spectroscopic data and was confirmed both by chemical degradation and by total synthesis. We proved that 3-bromo-1-piperideine was implicated in its formation. Moreover, based on this feature, a new and efficient synthesis of 6 was developed. The elaborated pathway was adapted to access derivatives related to 6 that differed in their C-4 substituent. A new and efficient synthesis of derivatives of the tricyclic heterocycle A from lysine is described. A mechanism involving 3-halopiperideines as intermediates and based on a ring contraction followed by Michael reaction is proposed and tested. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


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