Organic and Biomimetic Chemistry Research Group

Gent, Belgium

Organic and Biomimetic Chemistry Research Group

Gent, Belgium

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Iyer A.,Organic and Biomimetic Chemistry Research Group | Van Lysebetten D.,Organic and Biomimetic Chemistry Research Group | Ruiz Garcia Y.,Organic and Biomimetic Chemistry Research Group | Louage B.,Ghent University | And 2 more authors.
Organic and Biomolecular Chemistry | Year: 2015

The basic DNA recognition region of the GCN4 protein comprising 23 amino acids has been modified to contain two optimally positioned cysteines which have been linked and stapled using cross-linkers of suitable lengths. This results in stapled peptides with a stabilized α-helical conformation which allows for DNA binding and concurrent enhancement of cellular uptake. This journal is © The Royal Society of Chemistry 2015.


Hoogewijs K.,Organic and Biomimetic Chemistry Research Group | Buyst D.,Organic and Biomimetic Chemistry Research Group | Winne J.M.,Organic and Biomimetic Chemistry Research Group | Martins J.C.,NMR and Structure Analysis | Madder A.,Organic and Biomimetic Chemistry Research Group
Chemical Communications | Year: 2013

A general method for the facile and versatile decoration of peptides is proposed exploiting furan based cycloaddition and electrophilic aromatic substitution reactions. Given the commercial availability of furylalanine derivatives for peptide synthesis, the current work significantly enlarges the toolbox of available methodologies for site specific labeling and conjugation of peptide probes. This journal is © The Royal Society of Chemistry 2013.


PubMed | Organic and Biomimetic Chemistry Research Group
Type: Journal Article | Journal: Organic & biomolecular chemistry | Year: 2015

The basic DNA recognition region of the GCN4 protein comprising 23 amino acids has been modified to contain two optimally positioned cysteines which have been linked and stapled using cross-linkers of suitable lengths. This results in stapled peptides with a stabilized -helical conformation which allows for DNA binding and concurrent enhancement of cellular uptake.

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