Organ Technologies Inc.

Tokyo, Japan

Organ Technologies Inc.

Tokyo, Japan

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Patent
Organ Technologies Inc. | Date: 2017-07-19

The present invention provides a method for efficiently manufacturing full-thickness skin with skin appendage. The present invention provides a method for manufacturing full-thickness skin with skin appendage, characterized in that said method comprises the following steps (a) - (d): (a) a step of stimulating an embryoid body with a bioactive substance that may activate the Wnt pathway, (b) a step of preparing a conjugate comprising all or a part of said embryoid body stimulated in step (a) and a scaffolding material, (c) a step of transplanting said conjugate prepared in said step (b) to an animal, and (d) a step of manufacturing full-thickness skin derived from said conjugate in said animal.


Patent
Organ Technologies Inc. | Date: 2013-01-28

The purpose of the present invention is to provide a dental implant which enables the formation of a functional periodontal tissue around the implant after the implantation of the implant. The dental implant according to the present invention is characterized in that a cell mass originated from a tooth germ tissue or a periodontal ligament tissue is placed on the surface of the implant and the surface of the implant on which the cell mass is to be placed is the whole or a part of a surface that is surrounded by an alveolar bone of a recipient during the implantation of the implant.


Patent
Organ Technologies Inc. | Date: 2015-12-23

The object of the present invention is to provide a method for manufacturing multiple teeth from one isolated tooth germ in order to increase the absolute number of tooth germs that can be employed for transplantation. The present invention relates to a method for manufacturing a tooth. More specifically, the present invention provides a method for manufacturing multiple teeth from one isolated tooth germ comprising the epithelial and mesenchymal tissue layers characterized in that it comprises the steps of: (a) completely or partially splitting one isolated tooth germ comprising the epithelial and mesenchymal tissue layers, wherein said splitting is characterized in splitting so that each splitted tooth germ portion respectively comprises a portion of said epithelial tissue layer and a portion of said mesenchymal tissue layer, and (b) culturing said splitted tooth germs in vitro or culturing in vivo in a living animal other than humans to form multiple teeth.


[Problem] To provide a technique for regenerating hair through the transplantation of hair follicle germ in which the color of the regenerated hair is controlled. [Solution] Provided is a method for producing a regenerative hair follicle germ for transplantation in which a color of hair that grows after transplantation is controlled, said method including: preparing a first cell mass including mesenchymal cells; preparing a second cell mass including epithelial cells; preparing a cell mass including pigment stem cells; binding the cell mass including the pigment stem cells to at least one among the first cell mass and the second cell mass, and closely contacting the first cell mass and the second cell mass, at least one of which has been bound to the cell mass including the pigment stem cells, and culturing them within a support.


Patent
Organ Technologies Inc. | Date: 2013-02-13

Problem to be Solved The object of the present invention is to provide a method for restoring the alveolar bone of a mammal with a missing tooth. Solution The present invention provides a method for restoring the alveolar bone in a mammal with a missing tooth comprising a step of transplanting a regenerated tooth unit to the said missing site. The regenerated tooth unit is characterized in that it has a periodontal tissue portion in addition to a tooth crown portion.


Patent
Organ Technologies Inc. | Date: 2015-07-15

The object of the present invention is to provide a technology that enables long-term preservation while maintaining the function of an organ or tissue for transplantation. A further object is utilizing this technology to provide a technology for suppressing tissue disorder accompanying warm ischemia and reperfusion as well as restoring an organ from a cardiac arrest donor to a level compatible for transplantation. A long-term maintenance method of a mammalian organ or tissue for transplantation that employs perfusion by a perfusate etc. is provided, comprising each ofthe following steps of (a) connecting a perfusate instream cannula for streaming said perfusate into said organ or tissue, (b) connecting a perfusate outstream cannula for streaming said perfusate out from said organ or tissue, and (c) perfusing a perfusate comprising an oxygen carrier and a blood coagulation inhibitor into said organ or tissue.


Patent
Organ Technologies Inc. | Date: 2014-02-07

The object of the present invention is to provide a method for manufacturing multiple teeth from one isolated tooth germ in order to increase the absolute number of tooth germs that can be employed for transplantation. The present invention relates to a method for manufacturing a tooth. More specifically, the present invention provides a method for manufacturing multiple teeth from one isolated tooth germ comprising the epithelial and mesenchymal tissue layers characterized in that it comprises the steps of: (a) completely or partially splitting one isolated tooth germ comprising the epithelial and mesenchymal tissue layers, wherein said splitting is characterized in splitting so that each splitted tooth germ portion respectively comprises a portion of said epithelial tissue layer and a portion of said mesenchymal tissue layer, and (b) culturing said splitted tooth germs in vitro or culturing in vivo in a living animal other than humans to form multiple teeth.


Patent
Organ Technologies Inc. | Date: 2013-02-13

Problem to be Solved The object of the present invention is to provide a method for culturing a regenerated tooth germ so that the shape of the tooth is not restricted by pressure or space even when cultured in vivo and the extension of the tooth can also be controlled. It is also an object to provide a method which allows transplantation of a regenerated tooth even when the missing tooth site is large. Solution The present invention provides a method for manufacturing a regenerated tooth unit comprising a step of disposing and culturing a regenerated tooth germ inside a spacer in vivo in the body of a mammal, wherein said spacer is configured so as to enable prevention of excessive pressure being applied to said regenerated tooth germ from a tissue inside the body of said mammal, and prevention of said regenerated tooth germ being extended to more than the maximum tolerance; and configured such that the regenerated tooth germ disposed inside is communicatable with the exterior of the spacer. A method for manufacturing a regenerated tooth unit comprising a step of disposing and culturing multiple regenerated tooth germs inside a spacer in vivo in the body of a mammal is also provided.


Patent
Organ Technologies Inc. | Date: 2015-01-14

The object of the present invention is to provide an implant that enables functional periodontium formation around the implant after transplantation of a dental implant. The dental implant of the present invention is characterized in that a tooth germ tissue-derived or a periodontal membrane tissue-derived cell mass is placed on the surface of the implant, the surface of the implant on which the cell mass is to be placed is the whole or a part of the surface which is surrounded by the alveolar bone of the recipient at the time of implant transplantation.


Patent
Organ Technologies Inc. | Date: 2014-05-21

Disclosed are a perfusion culture method and a perfusion culture device whereby a perfusate can be delivered to all parts of an organ or tissue so that the organ or tissue can be preserved while sufficiently maintaining the function thereof. Specifically disclosed is a method for perfusion culture of an organ or tissue removed from a mammal, said organ or tissue having been removed together with a second organ or tissue connected to the aforesaid organ or tissue in vivo, which comprises a step for fixing said second organ or tissue so as to hang the aforesaid organ or tissue and a step for perfusing blood vessels in the aforesaid organ or tissue with a perfusate.

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